An interventional study of Ice Application and Room-Temperature Water-Bag Application in Peripheral Intravenous Phlebitis, Injection Site Pain and Pain, sponsored by Central Taiwan University of Science and Technology. Completed at 1 site in Taiwan. Open to participants aged 20 Years to 60 Years. Per ClinicalTrials.gov, last updated 2026-09-15.
Sponsored by Central Taiwan University of Science and Technology · Not applicable, Interventional, and Prevention
This randomized controlled trial evaluated whether ice application could reduce pain and peripheral intravenous phlebitis associated with oxacillin administration. Hospitalized patients receiving intravenous oxacillin were assigned to either an ice application group or a control group. In the intervention group, ice was applied to the area around the peripheral intravenous catheter before oxacillin administration. In the control group, a room-temperature water bag was applied in the same manner. Pain after oxacillin administration and signs of phlebitis at the intravenous catheter site were assessed and compared between the two groups. The study aimed to determine whether ice application could provide a simple, non-pharmacological approach to reducing oxacillin-related pain and phlebitis.
10,054 studies on the registry are indexed under Pain; 1,649 are open to participants now.
This study's enrollment of 86 is above the median of 66 across 8,493 interventional studies indexed under Pain.
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Adults aged 20 to 60 years. Conscious and able to participate in the study. Intravenous injection site located on either hand. Receiving a single antibiotic medication during the study. Eligible regardless of sex or medical diagnosis.
Exclusion Criteria:
Dementia. Psychiatric disorders. Skin rash at the study site. Purpura. Pregnancy. Current oral use. Hemodialysis. Administration of a second medication or an injection containing two or more medications during the study.
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Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
Corticosteroids (steroids)
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Participants assigned to this group received ice application around the peripheral intravenous catheter site before intravenous oxacillin administration.
Other: Ice Application
Participants assigned to this group received a room-temperature water-bag application around the peripheral intravenous catheter site before intravenous oxacillin administration.
Other: Room-Temperature Water-Bag Application
Ice was applied around the peripheral intravenous catheter site before intravenous oxacillin administration. The intervention was intended to reduce pain associated with oxacillin administration and the occurrence of peripheral intravenous phlebitis.
A room-temperature water bag was applied around the peripheral intravenous catheter site before intravenous oxacillin administration as the control condition.
Pain Intensity After Intravenous Oxacillin Administration
Pain intensity associated with intravenous oxacillin administration was assessed repeatedly after oxacillin administration across nine 8-hour intervals during the 72-hour observation period. Higher pain scores indicated greater pain intensity.
Time frame: Up to 72 hours after intravenous oxacillin administration
Pain Intensity After Intravenous Oxacillin Administration
Pain intensity associated with intravenous oxacillin administration was assessed using a numerical rating scale, with higher scores indicating greater pain. Pain was assessed repeatedly after oxacillin administration across nine 8-hour intervals during the 72-hour observation period.
Time frame: From 1 to 72 hours after initiation of the study intervention, assessed at 1-8, 9-16, 17-24, 25-32, 33-40, 41-48, 49-56, 57-64, and 65-72 hours.
Plan to share: No
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This study is completed, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.
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Central Taiwan University of Science and Technology