An interventional study of Eyebrow serum containing SDS-DNA-2/RNA-6 and Control eyebrow serum without SDS-DNA-2/RNA-6 in Eyebrow Growth, sponsored by BIONEER Corporation. Completed at 1 site in South Korea. Open to participants aged 20 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-09-15.
Sponsored by BIONEER Corporation · Not applicable, Interventional, and Other
This study evaluated the effects of CosmeRNA Brow Revitalizing Serum on eyebrow density and length in healthy Korean adults. Each participant applied the investigational serum to one eyebrow and a control serum to the other eyebrow once daily for 8 weeks. Eyebrow density and length were assessed before product use and after 4 and 8 weeks of use. Product compliance, participant-reported outcomes, and skin adverse reactions were also evaluated.
This was an 8-week, within-participant, controlled human application study conducted in healthy Korean adults aged 20 years or older.
For each participant, the face was divided vertically, with one eyebrow assigned to the investigational product and the contralateral eyebrow assigned to the control product. The investigational product was CosmeRNA Brow Revitalizing Serum, and the control product was a vehicle control serum. Participants applied an appropriate amount of each assigned product to the corresponding eyebrow once daily, either in the morning or evening, for 8 weeks.
Eyebrow density was evaluated using Folliscope 5.0. Images of the eyebrow areas were obtained at baseline and after 4 and 8 weeks of product use. For repeated measurements, eyebrow hairs in the assessment areas were trimmed, and phototrichogram analysis was performed to determine the number of eyebrow hairs per square centimeter.
Eyebrow length was evaluated from images obtained using Folliscope 5.0 at baseline and after 4 and 8 weeks. Eyebrow hair length was analyzed using Image-Pro 10 image analysis software.
Compliance was assessed using participant-completed product-use diaries. Participants also completed a questionnaire regarding their experience with the investigational product. Throughout the study, investigators monitored skin adverse reactions and the use of concomitant medications that could affect study evaluation.
BIONEER Corporation is the lead sponsor of 2 studies on the registry; none are open to participants now.
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Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Corticosteroids (steroids)
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
CosmeRNA Brow Revitalizing Serum containing SDS-DNA-2/RNA-6 was applied to the assigned eyebrow once daily for 8 weeks.
Other: Eyebrow serum containing SDS-DNA-2/RNA-6
The control serum formulated without SDS-DNA-2/RNA-6 was applied to the assigned eyebrow once daily for 8 weeks.
Other: Control eyebrow serum without SDS-DNA-2/RNA-6
A transparent, viscous cosmetic serum containing SDS-DNA-2/RNA-6. Participants applied an appropriate amount to the assigned eyebrow once daily, in the morning or evening, for 8 weeks. After application, the eyebrow area was gently massaged using the silicone applicator tip and lightly patted to aid absorption.
A transparent, viscous control cosmetic serum formulated without SDS-DNA-2/RNA-6. Participants applied an appropriate amount to the assigned eyebrow once daily, in the morning or evening, for 8 weeks, using the same application procedure as for the investigational serum.
Change From Baseline in Eyebrow Density
Eyebrow density was measured as the total number of eyebrow hairs per square centimeter using phototrichogram images obtained with Folliscope 5.0. Changes from baseline were evaluated for the eyebrow treated with the investigational serum and the contralateral eyebrow treated with the control serum.
Time frame: Baseline to Week 4 and Baseline to Week 8
Change From Baseline in Eyebrow Hair Length
Eyebrow hair length was measured in pixels using Image-Pro 10 software applied to images obtained with Folliscope 5.0. Changes from baseline were evaluated for the eyebrow treated with the investigational serum and the contralateral eyebrow treated with the control serum.
Time frame: Baseline to Week 4 and Baseline to Week 8
Participant-Reported Evaluation of the Investigational Serum
Participants evaluated their experience with the investigational serum using a 6-point questionnaire, where 1 indicated "strongly disagree" and 6 indicated "strongly agree." Responses of 4 to 6 were classified as positive responses. Results were summarized as the percentage of participants providing a positive response to each questionnaire item.
Time frame: Week 8
Incidence of Skin Adverse Reactions
Skin adverse reactions were assessed throughout the study based on participant reports and physical examination by a dermatologist. The outcome was summarized as the number of participants with any skin adverse reaction during product use.
Time frame: From baseline through Week 8
Product Use Compliance
Compliance was calculated as the percentage of required applications documented as completed in participant product-use diaries. Participants with compliance below 80% were considered noncompliant according to the prespecified criteria.
Time frame: From baseline through Week 8
Plan to share: No
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