An interventional study of Holy basil extract and Placebo in Sensitive Skin Related to Stress, sponsored by Laboratoires Expanscience S.A.. Recruiting at 1 site in Spain. Open to female participants aged 45 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-09-10.
Sponsored by Laboratoires Expanscience S.A. · Not applicable, Interventional, and Treatment
Stress can have multiple and varied psychological and clinical impacts on skin diseases (Colavincenzo and Granstein, 2006; Graubard et al., 2021). In particular, psychological stress has been shown to reduce the rebuilding kinetics of the skin barrier when altered and it is suggested that psychological stress may trigger or exacerbate immune-mediated dermatological disorders (Hall et al., 2012). Certain symptoms related to sensitive skin problems (itching, burning, pain, etc.) can lead to sleep disorders associated with stress and anxiety. Conversely, these sleep disorders and anxiety or stress due to external sources are known to promote the appearance of symptoms related to skin sensitivity in patients who are at risk of developing sensitive skin syndrome (Farage, 2022).
Expanscience Laboratories, manufacturer of cosmetics and dietary supplements, has identified a HOLY BASIL plant extract as a solution to address the negative impacts of stress on sensitive skin symptoms.
The main goal of this double blinded randomized controlled clinical study is to evaluate in vivo the effect of an active ingredient HOLY BASIL incorporated into a food supplement on sensitive skin symptoms related to psychological stress after 28 and 56 consecutive days of a twice-daily intake, in comparison with the baseline and a placebo. Evaluation of the effectiveness of HOLY BASIL will be evaluated using psychometric questionnaires related to stress, sensitive skin and overall perception.
Laboratoires Expanscience S.A. is the lead sponsor of 2 studies on the registry; 1 is open to participants now.
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Exclusion Criteria:
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The other ingredients in a medicine besides the active drug, such as fillers, colours or preservatives.
Excipients
The other ingredients in a medicine besides the active drug, such as fillers, colours or preservatives.
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Administration of HOLY BASIL
Dietary Supplement: Holy basil extract
Administration of Placebo
Dietary Supplement: Placebo
2 pills per day
2 pills per day
Sensitive skin symptoms
Evaluation using Sensitive Scale-10 (SS-10) questionnaire
Time frame: At baseline and after 28 days and 56 days
Perceived stress
Evaluation using PSS-10 questionnaire
Time frame: At baseline and after 28 days and 56 days
Self perception
Assessment using self assessment questionnaire
Time frame: After 28 days and 56 days
Plan to share: Undecided
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Studies of the drug tested here: Holy basil leaf extract
Laboratoires Expanscience S.A.