CClinicalTrials.gg
CompletedNCT07799766WWUpdated Sep 2, 2026

WorkWell - Preventing Prescription Opioid Misuse Among Employees Working in High Risk Industries

An interventional study of WorkWell in Opioids, sponsored by Prevention Strategies, LLC. Completed at 2 sites in United States. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-09-02.

Sponsored by Prevention Strategies, LLC · Not applicable, Interventional, and Prevention

Phase
Not applicable
Study type
Interventional
Enrollment
759
Allocation
Randomized
Ages
18 Years and older
Sex
All
01

Study summary

WorkWell is a mobile-delivered behavioral intervention designed to prevent prescription opioid misuse and overuse among construction workers and healthcare workers. Two sequential randomized factorial optimization trials evaluated intervention lessons targeting opioid-related beliefs, norms, pain-management alternatives, and patient-provider communication. Participants completed assessments at baseline, immediately after the intervention, and approximately 30 days later.

02

Conditions studied

  • Opioids
03

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

Age 18 years or older Construction worker, nurse, or nursing assistant

Exclusion criteria

Exclusion Criteria:

Under 18 years of age Not employed as a construction worker, nurse, or nursing assistant

04

Study design

Phase
Not applicable
Primary purpose
Prevention
Allocation
Randomized
Intervention model
Factorial assignment
Masking
None (open label)
Enrollment
759 participants (actual)

Study arms

  • Experimental
    Knowledge Lesson Only

    Participants received the WorkWell Knowledge lesson but did not receive the four experimentally varied lessons: Norms, Expectancies, Pain Management Alternatives, or Patient-Provider Communication.

    Behavioral: WorkWell

  • Experimental
    Knowledge + Norms

    Participants received the Knowledge lesson and the Norms lesson.

    Behavioral: WorkWell

  • Experimental
    Knowledge + Expectancies

    Participants received the Knowledge lesson and the Expectancies lesson.

    Behavioral: WorkWell

  • Experimental
    Knowledge + Pain Management Alternatives

    Participants received the Knowledge lesson and the Pain Management Alternatives lesson.

    Behavioral: WorkWell

  • Experimental
    Knowledge + Patient-Provider Communication

    Participants received the Knowledge lesson and the Patient-Provider Communication lesson.

    Behavioral: WorkWell

  • Experimental
    Knowledge + Norms + Expectancies

    Participants received the Knowledge, Norms, and Expectancies lessons.

    Behavioral: WorkWell

  • Experimental
    Knowledge + Norms + Pain Management

    Participants received the Knowledge, Norms, and Pain Management Alternatives lessons.

    Behavioral: WorkWell

  • Experimental
    Knowledge + Norms + Patient-Provider Communication

    Participants received the Knowledge, Norms, and Patient-Provider Communication lessons.

    Behavioral: WorkWell

  • Experimental
    Knowledge + Expectancies + Pain Management Alternatives

    Participants received the Knowledge, Expectancies, and Pain Management Alternatives lessons.

    Behavioral: WorkWell

  • Experimental
    Knowledge + Expectancies + Patient-Provider Communication

    Participants received the Knowledge, Expectancies, and Patient-Provider Communication lessons.

    Behavioral: WorkWell

  • Experimental
    Knowledge + Pain Management + Patient-Provider Communication

    Participants received the Knowledge, Pain Management Alternatives, and Patient-Provider Communication lessons.

    Behavioral: WorkWell

  • Experimental
    Knowledge + Norms + Expectancies + Pain Management

    Participants received the Knowledge, Norms, Expectancies, and Pain Management Alternatives lessons.

    Behavioral: WorkWell

  • Experimental
    Knowledge + Norms + Expectancies + Patient-Provider Communication

    Participants received the Knowledge, Norms, Expectancies, and Patient-Provider Communication lessons.

    Behavioral: WorkWell

  • Experimental
    Knowledge + Norms + Pain Management Alternatives + Patient-Provider Communication

    Participants received the Knowledge, Norms, Pain Management Alternatives, and Patient-Provider Communication lessons.

    Behavioral: WorkWell

  • Experimental
    Knowledge + Expectancies + Pain Management Alternatives + Patient-Provider Communication

    Participants received the Knowledge, Expectancies, Pain Management Alternatives, and Patient-Provider Communication lessons.

    Behavioral: WorkWell

  • Experimental
    All WorkWell Lessons

    Participants received the Knowledge, Norms, Expectancies, Pain Management Alternatives, and Patient-Provider Communication lessons.

    Behavioral: WorkWell

Interventions

  • BehavioralWorkWell

    Mobile-delivered behavioral intervention designed to prevent prescription opioid misuse and overuse among construction workers and nurses. WorkWell includes lessons addressing opioid-related knowledge, expectancies, norms, pain management alternatives, and patient-provider communication.

05

What researchers measure

Primary outcomes

  1. Expectancies

    Prescription opioid misuse and/or overuse expectancies held by construction workers and nurses.

    Time frame: Measured at pre-survey, immediate post survey, and then 30 days following post survey

  2. Normative Perceptions

    Prescription opioid misuse and/or overuse normative perceptions held by construction workers and nurses.

    Time frame: Measured at pre-survey, immediate post survey, and then 30 days following post survey

  3. Behavioral Contral

    Perceived behavioral control of prescription opioid misuse and/or overuse intentions held by construction workers and nurses.

    Time frame: Measured at pre-survey, immediate post survey, and then 30 days following post survey

  4. Intentions

    Intentions to misuse and/or overuse prescription opioids among construction workers and nurses.

    Time frame: Measured at pre-survey, immediate post survey, and then 30 days following post survey

Secondary outcomes

  1. Initiation

    Initiation of prescription opioid misuse and/or overuse among construction workers and nurses.

    Time frame: Measured at pre-survey and then 30 days following post survey

  2. Opioid Misuse

    Prescription opioid misuse reported by construction workers and nurses.

    Time frame: Measured at pre-survey and then 30 days following post survey

  3. Opioid Overuse

    Prescription opioid overuse reported by construction workers.

    Time frame: Measured at pre-survey and then 30 days following post survey

06

Study locations

2 sites
  • Cone Health
    Greensboro, North Carolina 27401, United States
  • Samet Corporation
    Greensboro, North Carolina 27409, United States
07

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

08

Registry details

Key details

Study ID
NCT07799766
Lead sponsor
Prevention Strategies, LLC
Collaborators
National Institute on Drug Abuse (NIDA)
Responsible party
Sponsor
First posted
Sep 2, 2026
Start date
Aug 7, 2024
Primary completion
Jan 5, 2026
Completion
Jan 5, 2026
Last update
Sep 2, 2026

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
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