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Not yet recruitingNCT07796269Updated Sep 14, 2026

Post-Extraction Wound Healing in Elderly

An observational study in Wound Healing, sponsored by University of Nebraska. Not yet recruiting at 1 site in United States. Open to participants aged 65 Years to 80 Years. Per ClinicalTrials.gov, last updated 2026-09-14.

Sponsored by University of Nebraska · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
72
Ages
65 Years to 80 Years
Sex
All
01

Study summary

Patients presenting to the University of Nebraska Medical Center College of Dentistry for a posterior extraction will be offered participation in the study. Prior to extraction, subjects will undergo clinical measurements, xray, gingival crevicular fluid (GCF) and saliva sampling and a blood draw. Following atraumatic tooth extraction, the subjects will be reevaluated for healing at 1, 2-weeks and 3 months. At each appointment, GCF, saliva and wound fluid (WF) will be collected and at 3 months a second xray will be taken.

02

Conditions studied

  • Wound Healing

Keywords

  • extraction
  • elderly
03

Who can participate

Ages eligible
65 Years to 80 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Study population will be made of patients at the UNMC College of Dentistry requiring posterior extraction, aged 65-80.

Inclusion criteria

  • needs posterior tooth extracted
  • no systemic conditions or meds affecting wound healing
  • non-smoker

Exclusion criteria

Exclusion Criteria:

  • systemic conditions or meds known to affect wound healing
  • smokers
04

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
72 participants (estimated)
Patient registry
No

Interventions

  • Proceduretooth extraction

    posterior tooth extraction

05

What researchers measure

Primary outcomes

  1. Amount of Interleukin-1 beta (IL1-B) in gingival crevicular at baseline

    Measurement of IL1B in GCF

    Time frame: Baseline

Secondary outcomes

  1. Bone Density

    Change in bone density post-extraction

    Time frame: 3 months

06

Study locations

1 site
  • University of Nebraska Medical Center College of Dentistry
    Lincoln, Nebraska 68583, United States
07

References and documents

Publications

  • Dignam P, Elshafey M, Jeganathan A, Foo M, Park JS, Ratnaweera M. Prevalence and Factors Influencing Post-Operative Complications following Tooth Extraction: A Narrative Review. Int J Dent. 2024;2024:7712829. Epub 20240509. doi: 10.1155/2024/7712829. PubMed PMID: 38756385; PMCID: PMC11098612. 2. Khalid KA, Nawi AFM, Zulkifli N, Barkat MA, Hadi H. Aging and Wound Healing of the Skin: A Review of Clinical and Pathophysiological Hallmarks. Life (Basel). 2022;12(12). Epub 20221219. doi: 10.3390/life12122142. PubMed PMID: 36556508; PMCID: PMC9784880. 3. Martin P, Pardo-Pastor C, Jenkins RG, Rosenblatt J. Imperfect wound healing sets the stage for chronic diseases. Science. 2024;386(6726):eadp2974. Epub 20241206. doi: 10.1126/science.adp2974. PubMed PMID: 39636982. 4. Amler MH. Age factor in human alveolar bone repair. J Oral Implantol. 1993;19(2):138-42. PubMed PMID: 8246300. 5. Elani HW, Starr JR, Da Silva JD, Gallucci GO. Trends in Dental Implant Use in the U.S., 1999-2016, and Projections to 2026. J Dent Res. 2018;97(13):1424-30. Epub 20180803. doi: 10.1177/0022034518792567. PubMed PMID: 30075090; PMCID: PMC6854267. 6. Udeabor SE, Heselich A, Al-Maawi S, Alqahtani AF, Sader R, Ghanaati S. Current Knowledge on the Healing of the Extraction Socket: A Narrative Review. Bioengineering (Basel). 2023;10(10). Epub 20230929. doi: 10.3390/bioengineering10101145. PubMed PMID: 37892875; PMCID: PMC10604628. 7. Sims NA. Influences of the IL-6 cytokine family on bone structure and function. Cytokine. 2021;146:155655. Epub 20210728. doi: 10.1016/j.cyto.2021.155655. PubMed PMID: 34332274. 8. Ramadan DE, Hariyani N, Indrawati R, Ridwan RD, Diyatri I. Cytokines and Chemokines in Periodontitis. Eur J Dent. 2020;14(3):483-95. Epub 20200623. doi: 10.1055/s-0040-1712718. PubMed PMID: 32575137; PMCID: PMC7440949. 9. Razavi P, Rezaee SA, Akhondian S, Asgari N, Fatemi K, Mohajertehran F. Matrix Metalloproteinase-3 but Not Matrix Metalloproteinase-9, Implicated in the Manifestation of

Individual participant data

Plan to share: No

08

Registry details

Key details

Study ID
NCT07796269
Lead sponsor
University of Nebraska
Responsible party
Sponsor
First posted
Sep 1, 2026
Start date
Nov 1, 2026 (estimated)
Primary completion
Nov 1, 2028 (estimated)
Completion
Nov 1, 2030 (estimated)
Last update
Sep 14, 2026

Study contacts

Amy Killeen, DDS, MS
Contact
akilleen@unmc.edu
4024727848

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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