An interventional study of Osteopathic Manipulation and Osteopathic manipulation in No Disease or Condition is Being Directly Studied and The Focus of the Study in Healthy Volunteers, sponsored by Lake Erie College of Osteopathic Medicine. Recruiting at 1 site in United States. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-09-23.
Sponsored by Lake Erie College of Osteopathic Medicine · Not applicable, Interventional, and Basic science
The investigators are studying if a specific osteopathic manipulative treatment protocol can improve the immune response (antibody titers) to seasonal influenza vaccination in vulnerable populations, including patients with advanced age and/or adiposity.
2,356 studies on the registry are indexed under Influenza, Human; 184 are open to participants now.
This study's planned enrollment of 50 is below the median of 227 across 1,957 interventional studies indexed under Influenza, Human.
Browse Influenza, Human studies →Lake Erie College of Osteopathic Medicine is the lead sponsor of 8 studies on the registry; 2 are open to participants now.
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Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Chronic obstructive pulmonary disease: long-term lung disease that makes it hard to breathe out, including emphysema and chronic bronchitis.
Cancer that has spread from where it began to other parts of the body. “Metastatic” cancer is cancer that has spread this way.
COPD
Chronic obstructive pulmonary disease: long-term lung disease that makes it hard to breathe out, including emphysema and chronic bronchitis.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Metastases
Cancer that has spread from where it began to other parts of the body. “Metastatic” cancer is cancer that has spread this way.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Only thoracic inlet myofascial release
Other: Osteopathic Manipulation
No intervention pre- or post-influenza vaccination.
Other: Sham
Multiple sites of OMT to occur post-influenza vaccination.
Other: Osteopathic manipulation
In this intervention, participants will receive 5 minutes of thoracic inlet myofascial release 2 days prior to influenza vaccination, the day of influenza vaccination and 4 days post-influenza vaccination.
In this intervention, participants will receive osteopathic manipulation 2 days prior to influenza vaccination, the day of influenza vaccination, and 4 days post-influenza vaccination. The OMT will include thoracic inlet myofascial release, pectoral traction, rib raising, doming of the diaphragm, pelvic diaphragm release, popliteal fossa release, plantar myofascial release, passive Miller thoracic pump, liver pump, and spleen pump.
In this intervention, participants will receive no osteopathic treatments
Hemagglutinin inhibition assay
Hemagglutinin inhibition assay assess the antibody titers in patient's blood.
Time frame: baseline and 4 weeks post vaccination
Plan to share: No
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Lake Erie College of Osteopathic Medicine