ClinicalTrials.gg
Not yet recruitingNCT07785453Updated Aug 25, 2026

Serum CTGF in Chronic Plantar Fasciitis

An observational study in Plantar Fasciitis, sponsored by Kanuni Sultan Suleyman Training and Research Hospital. Not yet recruiting. Open to participants aged 18 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-08-25.

Sponsored by Kanuni Sultan Suleyman Training and Research Hospital · Observational

Study type
Observational
Model
Case-control
Time perspective
Prospective
Enrollment
60
Ages
18 Years to 65 Years
Sex
All
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Study summary

This observational study aims to evaluate serum Connective Tissue Growth Factor (CTGF/CCN2) levels in patients with chronic plantar fasciitis compared with asymptomatic controls. The study will also assess the associations between serum CTGF levels and clinical and ultrasonographic characteristics of chronic plantar fasciitis.

Read the detailed description

This is a single-center observational study including patients with chronic plantar fasciitis and asymptomatic controls. Serum CTGF/CCN2 levels will be evaluated, and their associations with clinical and ultrasonographic characteristics will be assessed.

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Conditions studied

  • Plantar Fasciitis

Browse trials for

03

In context

Fasciitis, Plantar

223 studies on the registry are indexed under Fasciitis, Plantar; 58 are open to participants now.

This study's planned enrollment of 60 is close to the median of 60 across 24 observational studies indexed under Fasciitis, Plantar.

Browse Fasciitis, Plantar studies →

Lead sponsor

Kanuni Sultan Suleyman Training and Research Hospital is the lead sponsor of 225 studies on the registry; 35 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years to 65 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

Adults aged 18-65 years, including patients with chronic plantar fasciitis and asymptomatic controls without clinical or ultrasonographic findings of plantar fasciitis.

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Age 18-65 years.
  • Written .
  • For the patient group: chronic plantar heel pain for at least 3 months, pain during the first steps in the morning or after prolonged rest, tenderness over the medial calcaneal tubercle, and clinical and ultrasonographic findings consistent with chronic plantar fasciitis.
  • For the control group: asymptomatic individuals without a previous diagnosis or clinical and ultrasonographic findings of plantar fasciitis.

Exclusion criteria

Exclusion Criteria:

  • Tarsal tunnel syndrome, calcaneal stress fracture, plantar fascia rupture, Achilles tendinopathy, heel fat pad syndrome, plantar fibromatosis, or other foot conditions causing plantar heel pain.
  • Diabetes mellitus.
  • Inflammatory rheumatic diseases or gout.
  • Chronic kidney or liver disease.
  • .
  • Active infection or disease
  • Pregnancy.
  • Previous foot or ankle surgery.
  • injection, -rich plasma (PRP), prolotherapy, extracorporeal shock wave therapy (ESWT), or other interventional treatment to the affected heel within the previous 3 months.
  • Serious systemic conditions that may affect serum CTGF/CCN2 levels.
Terms in these criteria, in plain language(5)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Informed consent

Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.

You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.

Cancer (malignancy)

Malignancy means cancer. Criteria about another or earlier malignancy ask whether you have had a different cancer, usually within a set number of years.

Some are commonly allowed, such as treated skin cancers other than melanoma and early cancers removed completely — check the exceptions this study lists.

Autoimmune disease

A condition in which the immune system attacks the body’s own tissues, such as rheumatoid arthritis, lupus, psoriasis, type 1 diabetes or inflammatory bowel disease.

Immunotherapy studies often leave out active autoimmune disease, and some name exceptions, such as thyroid disease on replacement hormone. Check the exceptions this study lists.

Corticosteroids (steroids)

Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.

Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.

Platelets

Blood cells that help blood clot. Too few raises the risk of bleeding and bruising. A usual adult range is about 150–400 × 10⁹/L (150,000–400,000 per µL); each lab has its own reference range.

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Study design

Observational model
Case-control
Time perspective
Prospective
Enrollment
60 participants (estimated)
Patient registry
No
Biospecimen retention
Samples without dna

Groups and cohorts

  • Chronic Plantar Fasciitis Group

    Patients with chronic plantar fasciitis diagnosed based on clinical and ultrasonographic evaluation.

  • Control Group

    Asymptomatic participants without clinical or ultrasonographic findings of plantar fasciitis.

06

What researchers measure

Primary outcomes

  1. Serum CTGF/CCN2 Level

    Serum Connective Tissue Growth Factor (CTGF/CCN2) levels will be measured in patients with chronic plantar fasciitis and asymptomatic controls.

    Time frame: At baseline

Secondary outcomes

  1. Pain Severity

    Pain severity will be assessed using a Visual Analog Scale (VAS), and its association with serum CTGF/CCN2 levels will be evaluated.

    Time frame: At baseline

  2. Foot Function Index

    Functional status will be assessed using the Foot Function Index (FFI), and its association with serum CTGF/CCN2 levels will be evaluated.

    Time frame: At baseline

  3. Plantar Fascia Thickness

    Plantar fascia thickness will be measured by musculoskeletal ultrasonography, and its association with serum CTGF/CCN2 levels will be evaluated.

    Time frame: At baseline

07

Study locations

No study locations are listed for this record.

08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reached

Start is estimated for Aug 2026; primary completion for Oct 2026, 2 months later.

How these figures are worked out, and which studies are left out of them.

Registered
Aug 21, 2026
First posted
Aug 25, 2026
StartEst.
Aug 30, 2026
Primary completionEst.
Oct 30, 2026
CompletionEst.
Nov 15, 2026
Last update
Aug 25, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Aug 25, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT07785453
Responsible party
Zeynep Karakuzu Güngör (Physical Medicine and Rehabilitation Specialist, Kanuni Sultan Suleyman Training and Research Hospital) — Principal investigator
First posted
Aug 25, 2026
Start date
Aug 30, 2026 (estimated)
Primary completion
Oct 30, 2026 (estimated)
Completion
Nov 15, 2026 (estimated)
Last update
Aug 25, 2026

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is not yet recruiting, as verified in Aug 2026. You cannot join it, but the record below documents what was studied.

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