An observational study in Fungal Diseases, Lung Cancer (NSCLC) and Microbioata, sponsored by 958th Army Hospital of the Chinese People's Liberation Army. Recruiting at 1 site in China. Open to participants aged 30 Years to 80 Years. Per ClinicalTrials.gov, last updated 2026-08-25.
Sponsored by 958th Army Hospital of the Chinese People's Liberation Army · Observational
This study aims to uncover the characteristics of the fungal flora in non-small cell lung cancer, and to investigate the relationship between pulmonary fungi and the various pathological subtypes, stages, clinical features of non-small cell lung cancer, as well as patient prognosis. It seeks to provide new perspectives for a comprehensive understanding of non-small cell lung cancer, as well as new approaches for its early diagnosis and prognosis assessment.
This project intends to study the structural characteristics and clinical relevance of fungal microbiota in lung tissue of patients with non-small cell lung cancer. The project plans to collect 500 lung tissue samples from patients undergoing lung cancer surgery, build an ecological map of non-small cell lung cancer fungi through high-throughput sequencing, and simultaneously carry out traditional fungi culture to obtain culturable strain resources, so as to build a resource bank of non-small cell lung cancer fungi. By integrating clinicopathological information and follow-up data, using bioinformatics and statistical methods, key landmark fungi were screened, and the correlation between fungal community structure and different pathological subtypes, stages and clinical characteristics of non-small cell lung cancer was analyzed.
This project intends to study the structural characteristics and clinical relevance of fungal microbiota in lung tissue of patients with non-small cell lung cancer. The project plans to collect 500 lung tissue samples from patients undergoing lung cancer surgery, build an ecological map of non-small cell lung cancer fungi through high-throughput sequencing, and simultaneously carry out traditional fungi culture to obtain culturable strain resources, so as to build a resource bank of non-small cell lung cancer fungi. By integrating clinicopathological information and follow-up data, using bioinformatics and statistical methods, key landmark fungi were screened, and the correlation between fungal community structure and different pathological subtypes, stages and clinical characteristics of non-small cell lung cancer was analyzed.
260 studies on the registry are indexed under Mycoses; 37 are open to participants now.
This study's planned enrollment of 10 is below the median of 153 across 85 observational studies indexed under Mycoses.
Browse Mycoses studies →This is the only study on the registry with 958th Army Hospital of the Chinese People's Liberation Army as lead sponsor.
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The research object is the patients who are newly diagnosed as "non-small cell lung cancer" and intend to undergo surgical resection
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Non-small cell lung cancer was diagnosed by before operation, frozen pathology during operation or paraffin section after operation; The patients were 30 to 80 years old; No chemotherapy, radiotherapy, targeted therapy or immunotherapy were given before operation;
Exclusion Criteria:
Patients who do not meet the inclusion criteria; Combined with primary malignant tumor of other systems or recurrence of lung cancer, combined with immunodeficiency disease; Acute exacerbation of , bronchial asthma, bronchiectasis with infection, tuberculosis and pneumoconiosis; recent use of antifungal drugs; Basic clinical information (such as pathological type, clinical stage and treatment plan) cannot be obtained;
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
A biopsy takes a small piece of tissue to examine. “Archival tissue” is a sample already taken, for example at diagnosis, and kept by the hospital.
Whether a stored sample will do depends on when it was taken, how much there is and what the study needs. Ask whether the study accepts your stored sample or needs a new biopsy.
Chronic obstructive pulmonary disease: long-term lung disease that makes it hard to breathe out, including emphysema and chronic bronchitis.
Biopsy and archival tissue
A biopsy takes a small piece of tissue to examine. “Archival tissue” is a sample already taken, for example at diagnosis, and kept by the hospital.
Whether a stored sample will do depends on when it was taken, how much there is and what the study needs. Ask whether the study accepts your stored sample or needs a new biopsy.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
COPD
Chronic obstructive pulmonary disease: long-term lung disease that makes it hard to breathe out, including emphysema and chronic bronchitis.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The samples included in this group were lung cancer tissues.
The samples included in this group were normal lung tissues.
the fungal microbial environment
Different fungal microbial environments were observed in different parts of lung tissue.
Time frame: baseline, pre-surgery
PDFs hosted by the registry, ClinicalTrials.gov.
Plan to share: No
Started Aug 2026 (actual). Primary completion is estimated for Jan 2028, 17 months after the start.
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