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RecruitingNCT07783399Carnitine SuppUpdated Oct 16, 2026

The Effects of Carnitine Supplementation on Oocytes in Women Undergoing IVF Process

An interventional study of L-Carnitine Group in Infertility (IVF Patients), sponsored by The Obstetrics and Gynaecology Clinic Narodni Front. Recruiting at 1 site in Serbia. Open to female participants aged 18 Years to 45 Years. Per ClinicalTrials.gov, last updated 2026-10-16.

Sponsored by The Obstetrics and Gynaecology Clinic Narodni Front · Not applicable, Interventional, and Basic science

From the registry’s dates

  • Started May 2026; still recruiting 5 months later.
Updated Oct 16, 2026Study completion movedGo to Updates ↓
Phase
Not applicable
Study type
Interventional
Enrollment
70
Allocation
Randomized
Ages
18 Years to 45 Years
Sex
Female
01

Study summary

The goal of this clinical trial is to learn whether supplementation with L-carnitine improves outcomes in women undergoing in vitro fertilization (IVF). It will also evaluate the effect of supplementation on oocyte quality, embryo quality, and pregnancy rates. The main questions it aims to answer are:

  • Does supplementation improve the number and quality of oocytes retrieved during IVF treatment?
  • Does supplementation improve the number and quality of embryos obtained after fertilization?
  • Does supplementation increase the rates of biochemical and clinical pregnancy?

Researchers will compare women receiving supplementation with women not receiving supplementation to determine whether the supplements improve IVF outcomes.

Read the detailed description

Participants will:

  • Be women undergoing IVF treatment at the Narodni Front Clinic of Gynecology and Obstetrics who meet the study eligibility criteria and agree to participate.
  • Be randomly assigned, using the sealed-envelope method, to one of two groups:
  • A supplementation group receiving L-arginine (500 mg), L-carnitine (500 mg), N-acetyl-L-carnitine (250 mg), and myo-inositol (1000 mg) daily.
  • A control group receiving no supplementation.
  • Take the assigned supplementation for 12 weeks before oocyte retrieval.
  • Undergo assessment of the number and quality of retrieved oocytes after oocyte aspiration as part of the standard IVF procedure.
  • If fertilization occurs and embryos are obtained, have the number and quality of embryos evaluated as part of the standard IVF procedure.
  • Have serum beta-human chorionic gonadotropin (β-hCG) measured 13 days after embryo transfer to assess biochemical pregnancy as part of the standard IVF procedure.
  • If biochemical pregnancy is achieved (β-hCG > 50 IU/L), undergo an ultrasound examination 35 days after embryo transfer to confirm clinical pregnancy as part of the standard IVF procedure.
02

Conditions studied

  • Infertility (IVF Patients)

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Keywords

  • supplementation
  • IVF
  • carnitine
03

In context

Infertility

2,085 studies on the registry are indexed under Infertility; 357 are open to participants now.

This study's planned enrollment of 70 is below the median of 135 across 1,412 interventional studies indexed under Infertility.

Browse Infertility studies →

Lead sponsor

This is the only study on the registry with The Obstetrics and Gynaecology Clinic Narodni Front as lead sponsor.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 45 Years
Sexes eligible
Female
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • women undergoing IVF process
  • women aged 18-45 years

Exclusion criteria

Exclusion Criteria:

  • obesity
  • severe kidney disease
  • liver insufficiency
  • endocrine disorders
  • the use of medications
Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Immunosuppression

A weakened immune system. It can come from an illness, such as HIV or some blood cancers, or from medicines that turn the immune system down, for example after an organ transplant or for an autoimmune disease; steroids at higher doses count.

Read whether the line is about a condition or about medicines, and which medicines and doses it means.

05

Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
70 participants (estimated)

Study arms

  • Experimental
    L-Carnitine Group

    Participants in this arm will receive oral L-carnitine supplementation at a dose of 500 mg daily (once daily, powder dissolved in water, orally) starting 12 weeks before the day of oocyte retrieval.

    Dietary Supplement: L-Carnitine Group

  • No intervention
    No supplementation

    Participants who have not used carnitin supplementation.

Interventions

  • Dietary supplementL-Carnitine Group

    A supplementation group will receive L-carnitine (500 mg) daily for 12 weeks before oocyte retrieval.

06

What researchers measure

Primary outcomes

  1. The impact of carnitine supplementation on the number of oocytes retrieved during in vitro fertilization and on IVF outcomes.

    Assessment of the total count of oocytes retrieved per patient during transvaginal ultrasound-guided oocyte retrieval following controlled ovarian stimulation. Unit of measure: number of oocytes /count/ Measurement tool: inverted light microscope

    Time frame: 3 months

  2. The impact of carnitine supplementation on the number of good quality oocytes (metaphase II (MII) oocytes) retrieved during oocyte pick-up

    Good quality oocytes (metaphase II oocytes) will be identified according to standard ESHRE consensus morphological criteria (evaluating polar body presence, cytoplasm texture, and zona pellucida integrity) using inverted light microscope as measurement tool, following denudation in cases of intracytoplasmatic sperm injection (ICSI) or Metaphase II (MII) oocytes will be identified based on successful fertilization (presence of two pronuclei, 2PN) using inverted light microscope following insemination as part of the IVF procedure. Unit of measure: number of metaphase II (MII) oocytes /count/ Measurement tool: inverted light microscope

    Time frame: 3 months

07

Study locations

1 of 1 sites recruiting
  • Clinic for Gynecology and Obstetrics Narodni Front
    Belgrade, Savski Venac 11000, Serbia
    Recruiting
08

References and documents

Publications

  • Placidi M, Di Emidio G, Virmani A, D'Alfonso A, Artini PG, D'Alessandro AM, Tatone C. Carnitines as Mitochondrial Modulators of Oocyte and Embryo Bioenergetics. Antioxidants (Basel). 2022 Apr 8;11(4):745. doi: 10.3390/antiox11040745. PubMed 35453430 ↗
  • Kalehoei E, Moradi M, Azadbakht M, Zhaleh H, Abadi SAL, Mahdiuni H, Gharzi A. Therapeutic effects of L-arginine, L-carnitine, and mesenchymal stem cell-conditioned medium on endometriosis-induced oocyte poor quality in an experimental mouse model. J Obstet Gynaecol Res. 2023 Apr;49(4):1180-1188. doi: 10.1111/jog.15569. Epub 2023 Feb 3. PubMed 36738084 ↗
  • Perovic MD, Sudar-Milovanovic EM, Simonovic ED, Resanovic IM, Draganic VD, Radakovic JD, Soldatovic IA, Isenovic ER. Hypothesis regarding the effects of gonadotropins on the level of free fatty acids and phospholipids in serum and follicular fluid during controlled ovarian stimulation. Med Hypotheses. 2019 Feb;123:30-34. doi: 10.1016/j.mehy.2018.11.021. Epub 2018 Dec 18. PubMed 30696588 ↗
  • Kitano Y, Hashimoto S, Matsumoto H, Yamochi T, Yamanaka M, Nakaoka Y, Fukuda A, Inoue M, Ikeda T, Morimoto Y. Oral administration of l-carnitine improves the clinical outcome of fertility in patients with IVF treatment. Gynecol Endocrinol. 2018 Aug;34(8):684-688. doi: 10.1080/09513590.2018.1431769. Epub 2018 Jan 29. PubMed 29378447 ↗
  • Hafezi M, Arabipoor A, Ghaffari F, Vesali S, Zareei M, Hessari ZH. Adding L-carnitine to antagonist ovarian stimulation doesn't improve the outcomes of IVF/ ICSI cycle in patients with polycystic ovarian syndrome: a double-blind randomized clinical trial. J Ovarian Res. 2024 Jan 9;17(1):9. doi: 10.1186/s13048-023-01319-7. PubMed 38191449 ↗
  • Dunning KR, Robker RL. Promoting lipid utilization with l-carnitine to improve oocyte quality. Anim Reprod Sci. 2012 Sep;134(1-2):69-75. doi: 10.1016/j.anireprosci.2012.08.013. Epub 2012 Aug 11. PubMed 22917873 ↗
  • Zhao W, Liu K, Zhang Y, Sun P, Zeringue E, Meng L, Ma H. The efficacy of orally administered L-carnitine in alleviating ovarian dysfunctions has laid the foundation for targeted in vivo use: a study employing self-control and propensity score matching. Front Endocrinol (Lausanne). 2024 Sep 18;15:1440182. doi: 10.3389/fendo.2024.1440182. eCollection 2024. PubMed 39359417 ↗

Study documents

PDFs hosted by the registry, ClinicalTrials.gov.

Individual participant data

Plan to share: No

09

Timeline

1 registry update since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedDate before it movedWhere the date was before it movedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Ran from May 2026 to primary completion in Sep 2026, 3 months.

Of 385 non-industry interventional studies with no phase under Infertility, half reached primary completion within 24 months of starting (the median), counting those still running; a quarter within 10 and three quarters within 46. This study's 3 months is below that.

Counting every sponsor, half of 416 studies reached it within 24 months; a quarter within 10 and three quarters within 43.

Completion moved once since we started tracking on Sep 25, 2026: Sep 2026 → Dec 2026, on Oct 16, 2026.

Earlier changes are on the record history on ClinicalTrials.gov ↗

How these figures are worked out, and which studies are left out of them.

Registered
Jul 20, 2026
First posted
Aug 24, 2026
StartActual
May 15, 2026
Primary completionActual
Sep 1, 2026
CompletionEst.
Dec 28, 2026was Sep 2026
Last update
Oct 16, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
Study completion
Sep 20, 2026→Dec 28, 2026
Oct 16, 2026
Show all 1 update
  1. Oct 16, 2026
    Study completion Sep 20, 2026→Dec 28, 2026

From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗

10

Registry details

Key details

Study ID
NCT07783399
Lead sponsor
The Obstetrics and Gynaecology Clinic Narodni Front
Responsible party
Milan Perović (Head of IVF Department, The Obstetrics and Gynaecology Clinic Narodni Front) — Principal investigator
First posted
Aug 24, 2026
Start date
May 15, 2026
Primary completion
Sep 1, 2026
Completion
Dec 28, 2026 (estimated)
Last update
Oct 16, 2026

Study contacts

Milan D PEROVIC, Ass. Prof., PhD
Contact
perovic.milan@gakfront.org
+381644184953

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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Studies of the drug tested here: Carnitine

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