An observational study in High-risk Pregnancy, sponsored by Istanbul Training and Research Hospital. Recruiting at 1 site in Turkey (Türkiye). Open to female participants aged 18 Years to 45 Years. Per ClinicalTrials.gov, last updated 2026-08-19.
Sponsored by Istanbul Training and Research Hospital · Observational
This prospective observational study aims to investigate the association between maternal thyroid function, maternal anxiety levels, and fetal cardiotocography parameters in high-risk pregnancies. Pregnant women at 32 weeks of gestation or later who are followed in the perinatology outpatient clinic for high-risk pregnancy will be included.
Maternal thyroid function test results, including thyroid-stimulating hormone (TSH) and free thyroxine (fT4), obtained as part of routine clinical care will be recorded. Maternal anxiety will be assessed using the Beck Anxiety Inventory. Fetal well-being will be evaluated using a routine 20-minute non-stress test (NST), including baseline fetal heart rate, accelerations, reactivity, and the presence of decelerations.
The associations between maternal anxiety scores, thyroid hormone levels and thyroid status, and fetal cardiotocography parameters will be analyzed. Sociodemographic and obstetric characteristics will also be evaluated in relation to these parameters.
Istanbul Training and Research Hospital is the lead sponsor of 66 studies on the registry; 15 are open to participants now.
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The study population will consist of women with high-risk singleton pregnancies at 32 weeks of gestation or later who are followed at the Perinatology Outpatient Clinic of Istanbul Training and Research Hospital and who undergo routine thyroid function testing and non-stress testing.
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Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Pregnant women with singleton high-risk pregnancies at 32 weeks of gestation or later who undergo routine thyroid function testing and non-stress testing as part of their clinical follow-up. Maternal anxiety will be assessed using the Beck Anxiety Inventory.
Association Between Maternal Anxiety Level and NST Parameters
The association between Beck Anxiety Inventory scores and fetal non-stress test parameters will be evaluated.
Time frame: At study enrollment, during the same-day assessment
Association Between Maternal Thyroid Function and NST Parameters
The association between maternal TSH and free T4 levels and fetal non-stress test parameters will be evaluated.
Time frame: At study enrollment, using third-trimester thyroid function test results and same-day NST assessment
Association of Sociodemographic and Obstetric Characteristics With Maternal Anxiety, Thyroid Function, and NST Parameters
Time frame: At study enrollment, using third-trimester thyroid function test results and same-day NST and anxiety assessment
Plan to share: Undecided
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Istanbul Training and Research Hospital