ClinicalTrials.gg
Not yet recruitingNCT07766447TRAUM-IMPACTUpdated Aug 14, 2026

Long-term Medical Impact of War Injuries on Military Personnel

An interventional study of biological and radiological examinations in War Injury and Physical Injury, sponsored by Direction Centrale du Service de Santé des Armées. Not yet recruiting. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-08-14.

Sponsored by Direction Centrale du Service de Santé des Armées · Not applicable, Interventional, and Diagnostic

Phase
Not applicable
Study type
Interventional
Enrollment
20
Allocation
Not applicable
Ages
18 Years and older
Sex
All
01

Study summary

Beyond short-term multidisciplinary care, the French Armed Forces Health Service provides medical and surgical care, followed by medical and social care and long-term support for the wounded, especially when they have suffered multiple injuries during operations and are severely disabled. This involves primary phases of rehabilitation to limit the after-effects, preserve the functional prognosis and increase the autonomy of the injured person; secondary medical and social phases of rehabilitation and reintegration to restore the injured person's place in society.

The reconstruction stages are therefore essential. However, little data is available on the evolution of these patients' general health.

A similar follow-up cohort was set up by the British Army to monitor physical injuries during the conflict in Afghanistan. The results suggest the possibility of long-term cardiovascular and neoplastic complications in this population.

Furthermore, there is no data available on the evolution of the health status of war wounded in France. A retrospective study is currently underway, TRAUM-IMPACT RETRO, with the aim of assessing the consequences of 10 years of operational engagements from 2013 to 2023. This study should enable the medical French army service to clarify the topography of injuries and the medical and social outcomes of casualties treated at the Percy National Military Institute of Surgery (HNIA Percy) during this period. Initially, a pilot study followed by a cohort study will enable the investigators to standardise the medical follow-up of war casualties and determine their medical and social outcomes.

The population studied in this clinical trial corresponds to all military personnel repatriated and treated at the Percy National Military Hospital for a war injury defined as follows: "Any physical injury of a certain degree of severity directly related to the presence of the enemy, i.e. in combat or indirectly through effective participation in war operations, preparatory to or consequential to combat. " The investigators hypothesise that severely disabled wounded soldiers are at risk of specific complications leading to excess morbidity and disability, complications associated with ageing, and a risk of social and professional isolation. As a result, the participants require lifelong monitoring to prevent, detect and manage these complications, thereby ensuring that the nation gives its wounded children the recognition the participants deserve.

02

Conditions studied

  • War Injury
  • Physical Injury
03

In context

Lead sponsor

Direction Centrale du Service de Santé des Armées is the lead sponsor of 95 studies on the registry; 33 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Age ≥ 18 years
  • French military patient
  • Patient wounded in action
  • Patient repatriated and treated at the Percy National Military Hospital for a physical war injury sustained between 2020 and 2025
  • > 1 year
  • Patient conscious and oriented at the time of inclusion
  • Patient with health insurance

Exclusion criteria

Exclusion Criteria:

  • Isolated psychological injury
  • Physical injury not related to war
  • Patient unable to give free consent, under guardianship or curatorship
  • Refusal to participate
Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Life expectancy

The study doctor’s estimate of how long someone is likely to live. Criteria use it so that people can stay in the study long enough for it to answer its question.

05

Study design

Phase
Not applicable
Primary purpose
Diagnostic
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
20 participants (estimated)

Study arms

  • Experimental
    War wounded repatriated and treated at the Percy National Institute of Military Medicine

    Other: biological and radiological examinations

Interventions

  • Otherbiological and radiological examinations

    The TRAUM-IMPACT study designed to assess the feasibility of establishing a long-term cohort study to monitor war casualties and will be carried out in parallel with the usual care provided.

06

What researchers measure

Primary outcomes

  1. The primary outcome is the feasibility of a standardized multidisciplinary follow-up strategy, assessed by patient recruitment rate, retention rate during follow-up, completion

    Health event reported during visits over the course of the study and type of injury at inclusion (multiple trauma, limb trauma, head trauma).

    Time frame: 2 years

Secondary outcomes

  1. Longitudinal evolution of quality of life according to type of injury

    Short-Forme (SF) 36 quality of life score

    Time frame: 2 years

  2. Longitudinal changes in gait performance

    Gait performance will be evaluated using both clinical and instrumented assessments, including walking speed, walking perimeter, Timed Up and Go (TUG) test, wearable sensor-based gait analysis (spatiotemporal gait parameters), static postural assessment, and balance evaluation. These measures will be used to quantify changes in mobility, stability, and functional recovery throughout follow-up.

    Time frame: 2 yaers

  3. Define predictive factors for the occurrence of a new diagnosis or new treatment (psychiatric illness, chronic illness, cardiovascular disease, neoplasia, or any relevant medical event).

    Search for the occurrence of a new diagnosis or new treatment (psychiatric illness, chronic illness, cardiovascular disease, neoplasia, or any relevant medical event) and predictive factors.

    Time frame: 2 yaers

  4. Level of generic pain

    Generic pain questionnaire (QDSA)

    Time frame: 2 years

  5. Level of anxiety and depression

    HAD anxiety/depression scale

    Time frame: 2 years

  6. Sleep quality

    Sleep disorder screening (Epworth score)

    Time frame: 2 years

  7. Level of physical inactivity

    Specific questionnaire on returning to sport/sedentary lifestyle

    Time frame: 2 years

  8. Addictive behaviours

    Addictive behaviour screening questionnaire (alcohol, tobacco, drugs)

    Time frame: 2 years

  9. Incidence of Post-Traumatic Stress Disorder

    PCLS-5 questionnaire

    Time frame: 2 years

07

Study locations

No study locations are listed for this record.

08

References and documents

Publications

  • Bennett AN, Dyball DM, Boos CJ, Fear NT, Schofield S, Bull AMJ, Cullinan P; ADVANCE Study. Study protocol for a prospective, longitudinal cohort study investigating the medical and psychosocial outcomes of UK combat casualties from the Afghanistan war: the ADVANCE Study. BMJ Open. 2020 Oct 30;10(10):e037850. doi: 10.1136/bmjopen-2020-037850. PubMed 33127630 ↗
  • Hoffmann C. Blessés de guerre français en Afghanistan: de la blessure à la réinsertion [Thèse d'exercice]. [France]: Université Pierre et Marie Curie (Paris). UFR de médecine Pierre et Marie Curie; 2014.
  • Visseren FLJ, Mach F, Smulders YM, Carballo D, Koskinas KC, Back M, Benetos A, Biffi A, Boavida JM, Capodanno D, Cosyns B, Crawford C, Davos CH, Desormais I, Di Angelantonio E, Franco OH, Halvorsen S, Hobbs FDR, Hollander M, Jankowska EA, Michal M, Sacco S, Sattar N, Tokgozoglu L, Tonstad S, Tsioufis KP, van Dis I, van Gelder IC, Wanner C, Williams B; ESC National Cardiac Societies; ESC Scientific Document Group. 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice. Eur Heart J. 2021 Sep 7;42(34):3227-3337. doi: 10.1093/eurheartj/ehab484. No abstract available. PubMed 34458905 ↗
  • Taylor AJ, Bindeman J, Feuerstein I, Cao F, Brazaitis M, O'Malley PG. Coronary calcium independently predicts incident premature coronary heart disease over measured cardiovascular risk factors: mean three-year outcomes in the Prospective Army Coronary Calcium (PACC) project. J Am Coll Cardiol. 2005 Sep 6;46(5):807-14. doi: 10.1016/j.jacc.2005.05.049. PubMed 16139129 ↗

Individual participant data

Plan to share: No — The conditions for the transfer of all or part of the research database will be decided by the Central Directorate of the Armed Forces Health Service (research sponsor) and will be set out in a written contract.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Aug 14, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT07766447
Lead sponsor
Direction Centrale du Service de Santé des Armées
Responsible party
Sponsor
First posted
Aug 14, 2026
Start date
Oct 1, 2026 (estimated)
Primary completion
Dec 2028 (estimated)
Completion
Dec 2028 (estimated)
Last update
Aug 14, 2026

Study contacts

Caroline DOUTRELON, Chief Medical Officer
Contact
caroline.doutrelon@intradef.gouv.fr
0033141466272

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is not yet recruiting, as verified in Mar 2026. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion