An interventional study of EndoExpedtion Serious game and Standard Written Patient Information in Endometriosis, sponsored by Karolinska Institutet. Not yet recruiting at 4 sites in Sweden. Open to female participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-08-11.
Sponsored by Karolinska Institutet · Not applicable, Interventional, and Supportive care
Among 14 studies in Endometriosis with a site in Sweden — 6 open to participants now, 6 under way, none of them phase 3. Endometriosis · Sweden.
Among the 14 studies in Endometriosis with a site in Sweden, this one is the 4th largest by planned enrollment of the 11 interventional ones, is the only one that started in 2026, is one of 5 with no phase, and was the 14th registered.
920 studies on the registry are indexed under Endometriosis; 266 are open to participants now.
This study's planned enrollment of 250 is above the median of 67 across 540 interventional studies indexed under Endometriosis.
Browse Endometriosis studies →6 of the 14 studies in Endometriosis with a site in Sweden are open now, in 1 country. Each count lists the studies.
Of the 176 Endometriosis studies recruiting now, 51 (29%) set no upper age limit and 123 (70%) stop at 75 or younger; 18 take children under 18; 39 take healthy volunteers.
This study: 18 Years and older · female · healthy volunteers too.
The full table on the hub →14 studies; the count open now beside each. This study's row is marked.
First in 2005; this study’s year is marked. 1 started in 2026.
Median enrollment 80 across the 11 interventional studies, 345 across the 3 observational. Of the 7 that completed or were terminated, 1 (14%) have results posted.
5 of 14 have an industry lead sponsor. The 10 most frequent:
Karolinska Institutet is the lead sponsor of 1,148 studies on the registry; 276 are open to participants now.
Karolinska Institutet has 3 studies filed under Endometriosis — fewer than ten, so there is no comparison to draw.
None of the studies under way reaches primary completion within a year.
Among the 14 studies in Endometriosis with a site in Sweden, from their registry updates:
Nothing recorded among them since 2026-09-25.
Endometriosis is a chronic disease that can negatively affect quality of life, daily functioning, fertility, and psychological well-being. Adequate patient education is important for informed decision-making and active participation in care, but traditional written information may not meet the needs of all patients.
This national multicenter randomized controlled trial will evaluate whether a serious game can improve patient satisfaction when delivering information about endometriosis and its treatment options compared with standard written information. Adults with suspected or confirmed endometriosis will be randomized to receive either game-based educational material (Endoexpedition) or traditional written information. The study will assess patient satisfaction, knowledge acquisition, engagement, knowledge retention, and user interaction with the educational platform. A total of 250 participants will be included and followed for up to one year.
Endometriosis is a chronic inflammatory disease affecting approximately 10% of women of reproductive age and is commonly associated with pelvic pain, dysmenorrhea, dyspareunia, reduced quality of life, and infertility. Despite the high prevalence and substantial impact on physical and psychological well-being, diagnosis is often delayed for several years. Adequate patient education is essential for informed decision-making, treatment adherence, and patient empowerment. However, patient information is traditionally delivered through written materials, which may not meet the needs and learning preferences of all individuals.
Interactive educational technologies, including serious games, have emerged as promising tools for patient education. Serious games combine educational content with engaging and interactive elements that may improve motivation, knowledge acquisition, and long-term retention of information. Previous research in other chronic diseases suggests that game-based learning can improve patient engagement and self-management, but no randomized controlled trial has evaluated this approach in individuals with endometriosis.
The EndoExpedition trial is a national multicenter, open-label, randomized controlled trial conducted at the four Swedish National Highly Specialized Care (NHV) centers for advanced endometriosis. Adults with suspected or confirmed endometriosis will be randomized in a 1:1 ratio to receive either standard written patient information or access to EndoExpedition, a serious game specifically developed to provide evidence-based information about endometriosis and its treatment options.
The serious game is based on current international guidelines and covers anatomy, pathophysiology, symptoms, diagnostic procedures, hormonal treatment, surgical treatment, and common misconceptions regarding endometriosis. Educational content is delivered through interactive storytelling, visual novel elements, puzzles, three-dimensional models, and feedback mechanisms designed to promote meaningful learning and user engagement.
The primary objective is to determine whether delivery of patient information through a serious game improves patient satisfaction compared with standard written information. Patient satisfaction will be measured using the validated Quality from the Patient's Perspective (QPP) questionnaire immediately after the intervention.
Secondary objectives include evaluating knowledge acquisition, knowledge retention after one year, perceived meaningfulness and engagement, and objective measures of game use, including active time, completed modules, access frequency, interactions, and drop-off patterns. The study will also explore whether demographic factors such as age, education level, and prior gaming experience influence learning outcomes and preferences for educational format.
A total of 250 participants will be enrolled. The results will provide evidence regarding the effectiveness of serious games as a patient education and decision-support tool for individuals with endometriosis and may inform future implementation of digital educational interventions within routine gynecological care.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Participants receive patient information about endometriosis and available treatment options through EndoExpedition, a serious game specifically developed for patient education. The game includes interactive learning modules covering anatomy, pathophysiology, symptoms, diagnostic procedures, hormonal treatment, surgical treatment, and common misconceptions regarding endometriosis.
Behavioral: EndoExpedtion Serious game
Participants receive standardized written patient information about endometriosis and available treatment options. The information corresponds to the educational content routinely provided at the participating National Highly Specialized Care (NHV) centers.
Behavioral: Standard Written Patient Information
A digital serious game designed to provide evidence-based patient education regarding endometriosis and its treatment options through interactive storytelling, visual learning elements, quizzes, and decision-support components.
Standardized written educational material regarding endometriosis, symptoms, diagnostic procedures, and treatment options provided as routine care at participating centers.
Patient satisfaction with information received
Patient satisfaction measured using the Quality from the Patient's Perspective (QPP) questionnaire. The primary endpoint is the Perceived Reality (PR) score for the single global satisfaction item of the validated Quality from the Patient's Perspective (QPP) questionnaire: "Overall, I am satisfied with the information I have received." Responses are rated on a 4-point Likert scale ranging from 1 (do not agree at all) to 4 (completely agree), where higher scores indicate greater satisfaction. Only this single QPP item is used for the primary outcome analysis.
Time frame: Day 1 (immediately after completion of the educational intervention serious game or written information)
Knowledge about endometriosis and treatment options
Knowledge assessed using a study-specific standardized knowledge questionnaire covering endometriosis, diagnostic procedures, and treatment options. The outcome is the total knowledge score, calculated as the number of correct answers. Scores range from 0 to 20, with higher scores indicating greater knowledge.
Time frame: Day 1. Immediately after receiving the educational intervention
Knowledge retention
Knowledge score based on the same standardized questionnaire administered at follow-up. The outcome is the total knowledge score, calculated as the number of correct answers. Scores range from 0 to 20, with higher scores indicating greater knowledge.
Time frame: 12 months after educational intervention
Perceived meaningfulness of the educational format
Perceived meaningfulness and engagement will be assessed using study-specific questionnaire items adapted from the Intrinsic Motivation Inventory (IMI). Each item is rated on a 7-point Likert scale ranging from 1 (not at all true) to 7 (very true), where higher scores indicate greater perceived meaningfulness and engagement with the educational intervention. The outcome will be reported as the mean score across the selected items.
Time frame: Day 1. Immediately after receiving the educational intervention
Total active game time
Total active game time recorded automatically through in-game activity logs. Active game time is measured in minutes, excluding idle time. Higher values indicate greater engagement with the educational intervention.
Time frame: Day 1. During game use from randomization until completion of the intervention
Active time per game chapter
Active time spent on each of the seven game chapters, recorded automatically through in-game activity logs. Time is reported in minutes per chapter, excluding idle time.
Time frame: Day 1. During game use from randomization until completion of the intervention.
Number of game chapters completed
Number of completed game chapters, recorded automatically through in-game activity logs. The total number of completed chapters ranges from 0 to 7, with higher values indicating greater completion of the educational intervention.
Time frame: Day 1. During game use from randomization until completion of the intervention
Game chapters accessed
Access to each of the seven topic-specific game chapters, recorded automatically through in-game activity logs. Results will be reported as the number and proportion of participants accessing each chapter.
Time frame: Day 1. During game use from randomization until completion of the intervention
Plan to share: Yes — De-identified individual participant data underlying the published results.
Supporting information: Study protocol, Statistical analysis plan, Analytic code
Time frame: Beginning 6 months after publication of the primary results and ending 5 years after publication.
Access criteria: Available upon reasonable request to the principal investigator. Requests will be evaluated by the Trial Steering Committee and require a methodologically sound research proposal, ethical approval where applicable, and a signed data-sharing agreement.
Start is estimated for Sep 2026; primary completion for Sep 2028, 24 months later.
Of 196 non-industry interventional studies with no phase under Endometriosis, half reached primary completion within 24 months of starting (the median), counting those still running; a quarter within 13 and three quarters within 44. This study's planned 24 months is close to that.
Counting every sponsor, half of 211 studies reached it within 25 months; a quarter within 13 and three quarters within 44.
How these figures are worked out, and which studies are left out of them.
This study is not yet recruiting, as verified in Aug 2026. You cannot join it, but the record below documents what was studied.
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