An interventional study of Photoactivated disinfection and Er,Cr:YSGG laser disinfection in Infected Extraction Sockets, sponsored by Alexandria University. Completed at 1 site in Egypt. Open to participants aged 20 Years to 60 Years. Per ClinicalTrials.gov, last updated 2026-08-07.
Sponsored by Alexandria University · Not applicable, Interventional, and Treatment
Background: Dental implantology offers reliable tooth replacement options, but infections in extraction sockets can compromise osseointegration. Conventional disinfection methods, such as chlorhexidine, often fail to completely eliminate pathogenic microorganisms and may impair tissue healing. Photoactivated disinfection (PAD) and laser disinfection have emerged as promising alternatives. PAD employs a light-activated photosensitizer to generate reactive oxygen species (ROS), effectively disrupting bacterial membranes while preserving host cell viability. In parallel, laser disinfection utilizes focused light energy to eliminate bacterial biofilms and contaminated tissue with minimal thermal damage. In this study, we specifically utilize the Er,Cr:YSGG laser, which operates at a water-absorbing wavelength to induce micro-explosions that mechanically disrupt biofilms and promote a cleaner socket environment for improved osseointegration. Aim of the study: To compare the effectiveness of photoactivated disinfection (PAD), Er,Cr:YSGG laser disinfection, and conventional disinfection with chlorhexidine in decontaminating infected extraction sockets prior to immediate implant placement, promoting bone healing, and improving the osseointegration and stability of immediate implants placed in infected extraction sockets.
Exclusion Criteria:
Other: Photoactivated disinfection
Other: Er,Cr:YSGG laser disinfection
Other: Chlorohexidine disinfection
Standard treatment + Toluidine blue + Light activation + Immediate implant placement
Standard treatment + Er,Cr:YSGG laser application + Immediate Implant placement
Standard treatment + Chlorohexidine Irrigation + Immediate Implant placement
implant stability
Resonance Frequency Analysis (RFA) using Osstell ISQ: Implant Stability Quotient (ISQ) values will be recorded at 6 months after implant placement. Values from 1 to 100, the higher the ISQ, the higher the stability of the implant.
Time frame: 6 months
change in bone density
Bone density assessment using radiographs immediately post-operative and at 6 months.
Time frame: baseline and 6 months
change in marginal bone loss
Marginal Bone Loss (MBL) assessment using radiographs immediately postoperative and at 6 months.
Time frame: baseline and 6 months
change in pain scores
Post-operative pain will be assessed through a 10-point visual analogue scale (VAS). (0-1 = No pain, 2-4 = mild pain, 5-7 = moderate pain, 8-10 = severe pain).
Time frame: up to 7 days
change in post-operative edema
Post-operative edema will be assessed as follows None (no swelling), Mild (intra oral swelling confined to surgical field), Moderate (extra oral swelling in the surgical zone), Severe (extra oral swelling spreading beyond the surgical zone)
Time frame: up to 7 days
This study is completed, as verified in Aug 2026. You cannot join it, but the record below documents what was studied.
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Alexandria University