A Phase 1/2 interventional study of Height based dose of hyperbaric bupivacaine 0.5% in Lower Limb Surgeries, sponsored by Liaquat National Hospital & Medical College. Not yet recruiting. Open to participants aged 18 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-08-07.
Sponsored by Liaquat National Hospital & Medical College · Phase 1/2, Interventional, and Supportive care
This study aim is to compare height based dose of spinal anesthesia vs conventional dose. Hypothesis is height based dose has less hemodynamics changes compared to conventional dosing.
This is a prospective, randomized, double blinded, controlled trial with minimum 6 months of data collection. Patients will be divided into two groups randomly. Group H and C each having 52 patients. Groups H will be given spinal anesthesia dose according to their height by pre determined dosing algorithm. Group C will be given a fixed dose of Hyperbaric Bupivacaine 0.5% 12.5mg (2.5ml) without adjusting it according to their height. Pateint's blood pressure and Heart rate along with sensory effect will be recorded 5,10 and 15 minutes later after spinal anesthesia. I will be recording any episode of bradycardia and hypotension and intervention needed to treat it in both the groups
Liaquat National Hospital & Medical College is the lead sponsor of 33 studies on the registry; 16 are open to participants now.
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Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
ASA physical status
The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Height based dose
Drug: Height based dose of hyperbaric bupivacaine 0.5%
Conventional dose of hyperbaric bupivacaine 0.5%
Drug: Height based dose of hyperbaric bupivacaine 0.5%
Height based vs Conventional dosing of spinal anesthesia in lower limb surgeries
Hypotension and Bradycardia
Time frame: 6 months
Icidence of hypotension and bradycardia
Time frame: 6 months
No study locations are listed for this record.
Plan to share: Yes
No publications or documents are linked to this record.
Start is estimated for Aug 2026; primary completion for Dec 2026, 4 months later.
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This study is not yet recruiting, as verified in Aug 2026. You cannot join it, but the record below documents what was studied.
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Liaquat National Hospital & Medical College