An interventional study of genicular artery embolization and Calibrated microspheres (100-300 µm) in Angioembolization in Knee Osteoarthritis, sponsored by Assiut University. Not yet recruiting. Open to participants aged 18 Years to 70 Years. Per ClinicalTrials.gov, last updated 2026-08-04.
Sponsored by Assiut University · Not applicable, Interventional, and Treatment
To evaluate the efficacy and safety of genicular artery embolization in patients with symptomatic knee osteoarthritis refractory to conservative treatment.
Assiut University is the lead sponsor of 4,901 studies on the registry; 2,098 are open to participants now.
Of its 13 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
Counted across the registry records on this site, refreshed daily.
Clinical diagnosis of knee osteoarthritis according to the criteria of the American College of Rheumatology.
Radiographic evidence of osteoarthritis corresponding to Kellgren-Lawrence grades I-III.
Moderate to severe knee pain for at least 6 months. Visual Analog Scale (VAS) score ≥5.
Exclusion Criteria:
Participants with symptomatic knee osteoarthritis will undergo super-selective genicular artery embolization using calibrated microspheres. Clinical outcomes will be assessed using pain and functional scores during follow-up.
Procedure: genicular artery embolization · Device: Calibrated microspheres (100-300 µm) · Device: Microcatheter
Super-selective embolization of abnormal genicular arteries supplying the painful synovium in patients with symptomatic knee osteoarthritis.
Embolic microspheres used for occlusion of the targeted genicular arteries during embolization.
A 2.0-2.4 Fr microcatheter used for super-selective catheterization of the genicular arteries.
change from baseline in visual analog scale (VAS) pain score
pain intensity measured using the 10-cm visual analog scale (VAS). scores range from 0 to 10, with higher scores indicating greater pain. The change from baseline to 6 months after genicular artery embolization will be assessed.
Time frame: Baseline and 6 months after the Procedure
Change from Baseline in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Total Score
Knee pain, stiffness, and physical function will be assessed using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). The total WOMAC score ranges from 0 to 96, where 0 indicates no symptoms and 96 indicates the most severe symptoms. Higher scores indicate worse pain, stiffness, and functional limitation.
Time frame: Baseline, 3 months, and 6 months after the procedure
Change from Baseline in Health-Related Quality of Life Score (EQ-5D-5L)
Health-related quality of life will be assessed using the EuroQol 5-Dimension 5-Level (EQ-5D-5L) questionnaire. The EQ-5D-5L descriptive system consists of five dimensions, each with five levels, and responses are converted into a utility index score ranging from values below 0 (health states worse than death) to 1.0 (full health), with higher scores indicating better health-related quality of life. Assessments will be performed at baseline, 3 months, and 6 months after the procedure.
Time frame: Baseline and 6 months after the procedure
Technical Success Rate of Genicular Artery Embolization
Technical success is defined as successful selective catheterization and embolization of all target genicular arteries with completion of the planned procedure.
Time frame: During the procedure
No study locations are listed for this record.
This study is not yet recruiting, as verified in Jul 2026. You cannot join it, but the record below documents what was studied.
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Assiut University