A Phase 3 interventional study of prophylactic radiation and standard of care in Bone Metastases, sponsored by Centre Henri Becquerel. Not yet recruiting at 2 sites in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-07-29.
Sponsored by Centre Henri Becquerel · Phase 3, Interventional, and Treatment
Radiation therapy is a common treatment for painful bone metastases, proving effective in 1 to 2/3 of cases after 1 to 10 sessions, with stereotactic body radiation therapy (SBRT) likely offering superior results.
Radiation therapy is also used to prevent bone events, although its use is not standardized; the decision to administer it is made by clinicians or through multidisciplinary team (MDT) discussions.
Recently, it has been shown that preventive radiation therapy can reduce the risk of skeletal-related events (SREs) in patients at high risk for bone events.
The objective is to compare active surveillance with preventive radiation therapy in patients at intermediate risk for bone events.
2,219 studies on the registry are indexed under Pain; 917 are open to participants now.
This study's planned enrollment of 154 is above the median of 70 across 1,904 interventional studies indexed under Pain.
Browse Pain studies →Centre Henri Becquerel is the lead sponsor of 57 studies on the registry; 19 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
no bone radiation for patient allocated in this arm
Drug: standard of care
patient undergo prophylactic radiation on bone metastases
Radiation: prophylactic radiation
Patients will undergo propthylactic radiation on bone metastases
Patients will have systemic treatment on the standard of care
Bone event
rate of bone event in the two arms
Time frame: one year
Plan to share: No
No publications or documents are linked to this record.
This study is not yet recruiting, as verified in Jul 2026. You cannot join it, but the record below documents what was studied.
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Centre Henri Becquerel