An observational study in Brain Health, sponsored by Guangzhou Medical University. Not yet recruiting at 1 site in China. Open to participants aged 18 Years to 75 Years. Per ClinicalTrials.gov, last updated 2026-07-22.
Sponsored by Guangzhou Medical University · Observational
This project conducts a prospective cohort study. By using multiple questionnaire survey methods such as the Pittsburgh Sleep Quality Index (PSQI) electronic wristband, QOR15, Pain Catastrophizing Scale (PCS), European Five-Dimensional Health Scale (EQ-5D), Revised American Pain Society Patient Follow-up Questionnaire (APS-POQ-R), Mini-Mental State Examination (MMSE), as well as perioperative stress and related indicators, hypothalamic-pituitary-adrenal axis (HPA) endocrine indicators, sublingual microcirculation, electroencephalogram, etc., comprehensive assessment is made of the correlations between the two different anesthesia methods of Tubeless retention of spontaneous breathing and double-lumen bronchial intubation and postoperative sleep, chronic pain and cognitive function, to construct a perioperative brain health safety system to improve prognosis; at the same time, optimize the perioperative sedation and analgesia plan and promote the postoperative brain health recovery of patients.
Guangzhou Medical University is the lead sponsor of 38 studies on the registry; 20 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients who underwent elective non-anatomic partial lung resection surgery at the First Affiliated Hospital of Guangzhou Medical University
Exclusion Criteria:
Patients undergoing elective non-anatomic partial lung resection surgery using the Tubeless technique for maintaining spontaneous breathing anesthesia
Patients undergoing elective non-anatomic lung segmentectomy surgery using the double-lumen bronchial tube anesthesia method
Concentration of cognitive function biomarkers in the serum samples of 400 patients
At time points T1, T2, and T3, 5 ml of peripheral venous blood was collected to test the biological indicators of postoperative cognitive function.
Time frame: Before the start of the surgery (T1), at the end of the surgery (T2), and on the first day after the surgery (T3)
Concentrations of HPA axis-related indicators in the serum samples of 400 patients
At the TI-T2 time point, 5 ml of peripheral venous blood was collected for the detection of HPA axis-related indicators.
Time frame: Before the start of the surgery (T1), at the end of the surgery (T2)
The concentrations of laboratory test indicators in the serum samples of 400 patients
Record the laboratory test indicators at time points T1 and T3
Time frame: Before the start of the surgery (T1), and on the first day after the surgery (T3)
Anesthesia Record Form
Record the vital signs at the T2 time point
Time frame: at the end of the surgery (T2)
Case information system collection
Record the pulmonary function, chest X-ray or chest CT at time points T1 and T3
Time frame: Before the start of the surgery (T1), and on the first day after the surgery (T3)
Anesthesia Record Form
Record the intraoperative conditions
Time frame: During the operation
Postoperative follow-up records
Record the time of chest tube removal after surgery
Time frame: through study completion, an average of 1 year
Postoperative follow-up records
the usage of postoperative analgesic drugs
Time frame: through study completion, an average of 1 year
Postoperative follow-up records
the postoperative hospital stay
Time frame: through study completion, an average of 1 year
Postoperative follow-up records
the total hospitalization cost
Time frame: through study completion, an average of 1 year
Postoperative follow-up records
Record the occurrence of adverse events during the perioperative period
Time frame: through study completion, an average of 1 year
Plan to share: Yes — Patient clinical data
Supporting information: Csr
No publications or documents are linked to this record.
This study is not yet recruiting, as verified in Jul 2026. You cannot join it, but the record below documents what was studied.
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Guangzhou Medical University