ClinicalTrials.gg
Not yet recruitingNCT07713784Updated Aug 28, 2026

Investigating ELSI Issues That May Facilitate or Impede Clinical Translation of Epigenetic Research. Phase 3b

An interventional study of Epigenetics Video and Individual Responsbility Video in Healthy, sponsored by Washington University School of Medicine. Not yet recruiting. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-08-28.

Sponsored by Washington University School of Medicine · Not applicable, Interventional, and Other

Phase
Not applicable
Study type
Interventional
Enrollment
1,000
Allocation
Randomized
Ages
18 Years and older
Sex
All
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Study summary

Few people realize that environmental pollution and some behaviors like physical activity and tobacco smoking can affect their health by "turning on" or "turning off" certain genes through a process called "epigenetic modification." This study will develop and test strategies for communicating about epigenetics that are understandable and that do not increase ethical, legal or social issues (ELSI).

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Conditions studied

  • Healthy

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Keywords

  • Epigenomics
  • Epigenetics
  • Genetics, Behavioral
  • Bioethics
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In context

Behavior

1,573 studies on the registry are indexed under Behavior; 313 are open to participants now.

This study's planned enrollment of 1,000 is above the median of 120 across 1,197 interventional studies indexed under Behavior.

Browse Behavior studies →

Lead sponsor

Washington University School of Medicine is the lead sponsor of 1,803 studies on the registry; 271 are open to participants now.

Of its 329 completed or terminated interventional studies of FDA-regulated products, 216 (66%) have results posted.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
Yes

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • English language speaker,
  • Identify as one of five racial/ethnic groups:

    1. Non-Hispanic White
    2. Non-Hispanic Black,
    3. Non-Hispanic Asian
    4. Non-Hispanic Indigenous (i.e., Alaska Native/Native Hawaiians/American Indian/Other Pacific Islander)
    5. Hispanic (all races)

Exclusion criteria

Exclusion Criteria:

  • Self-identify as a genetics expert
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Study design

Phase
Not applicable
Primary purpose
Other
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
1,000 participants (estimated)

Study arms

  • Active comparator
    Epigenetics Video

    Participants will watch a brief (\<5 minute) video about the concept of Epigenetics

    Behavioral: Epigenetics Video

  • Experimental
    Individual Responsibility Video

    Participants will watch a brief (\<5 minute) video about the concept of Epigenetics as well as a brief (\<1 minute) video discussing epigenetics and health with a focus on individual behavioral factors affecting epigenetics.

    Behavioral: Epigenetics Video · Behavioral: Individual Responsbility Video

  • Experimental
    External Responsibility Video

    Participants will watch a brief (\<5 minute) video about the concept of Epigenetics as well as a brief (\<1 minute) video discussing epigenetics and health with a focus on external factors affecting epigenetics.

    Behavioral: Epigenetics Video · Behavioral: External Responsibility Video

Interventions

  • BehavioralEpigenetics Video

    Video about the concept of epigenetics

  • BehavioralIndividual Responsbility Video

    Video discussing epigenetics and health with a focus on individual behavioral factors affecting epigenetics.

  • BehavioralExternal Responsibility Video

    Video discussing epigenetics and health with a focus on external factors affecting epigenetics.

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What researchers measure

Primary outcomes

  1. Knowledge & understanding of epigenetics Information

    Sum score of correct answers for 11 individual items. Scale ranges from 0 points to 11 points with higher scores indicating higher epigenetics knowledge.

    Time frame: Baseline survey, after intervention video

  2. Acceptability of epigenetics information

    Three constructs including perceived benefits of epigenetic research (7 items, ranging from 1 to 5 with higher scores indicating higher perceived benefits), perceived drawbacks of epigenetic research (3 items, ranging from 1 to 5 with higher scores indicating higher perceived drawbacks), and acceptance of using epigenetic research in medical support (3 items, ranging from 1 to 5 with higher scores indicating higher acceptance of using epigenetic research in medical support).

    Time frame: Baseline survey, after intervention video

Secondary outcomes

  1. Perceptions of epigenetic information

    6 item scale. Scores range from 1 to 5, with higher scores indicating greater perceptions of epigenetic information.

    Time frame: Baseline survey, after intervention video

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Study locations

No study locations are listed for this record.

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References and documents

Study documents

PDFs hosted by the registry, ClinicalTrials.gov.

Individual participant data

Plan to share: Yes

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Aug 28, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT07713784
Responsible party
Sponsor
First posted
Jul 20, 2026
Start date
Aug 1, 2026 (estimated)
Primary completion
Oct 1, 2026 (estimated)
Completion
Oct 1, 2026 (estimated)
Last update
Aug 28, 2026

Study contacts

Julia M Maki, PhD
Contact
jmaki@wustl.edu
314-286-2835
Erika Waters, PhD, MPH
Contact
waterse@wustl.edu
314-747-5705

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is not yet recruiting, as verified in Jul 2026. You cannot join it, but the record below documents what was studied.

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