An observational study in Exophthalmometry and Normal Exophthalmometric Values, sponsored by Instituto de Oftalmología Fundación Conde de Valenciana. Recruiting at 1 site in Mexico. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-07-15.
Sponsored by Instituto de Oftalmología Fundación Conde de Valenciana · Observational
Proptosis assessment using Hertel exophthalmometry is an essential part of the ophthalmic examination, but normal reference values vary among different populations. This observational study aims to establish normative Hertel exophthalmometry values in Mexican adults and to evaluate their association with demographic characteristics (such as age and sex) and systemic diseases. Healthy adult participants and adults with selected systemic conditions will undergo standardized Hertel exophthalmometry measurements. The findings are expected to provide population-specific reference values that may improve the clinical assessment of orbital diseases in the Mexican population.
Background: Hertel exophthalmometry is the most commonly used method for measuring globe protrusion in clinical practice. Normal exophthalmometric values vary according to ethnicity, sex, age, and craniofacial anatomy; therefore, population-specific reference values are necessary for accurate clinical interpretation. Currently, normative data for Mexican adults are limited.
Objective: To establish normative Hertel exophthalmometry values in Mexican adults and to evaluate their association with demographic characteristics and systemic diseases.
Methods: This is a prospective observational study. Adult participants attending the Ophthalmology Department will be consecutively recruited after providing written informed consent. Hertel exophthalmometry measurements will be obtained using a standardized technique by trained examiners. Demographic information, including age and sex, as well as relevant medical history and systemic diseases, will be recorded. The primary outcome is the distribution of Hertel exophthalmometry values in the study population. Secondary analyses will assess associations between exophthalmometric measurements and demographic or systemic variables.
Expected Significance: The study will provide normative Hertel exophthalmometry values for the Mexican adult population and identify factors associated with physiological variations in globe protrusion. These findings may improve the clinical evaluation of patients with suspected orbital disease and facilitate interpretation of Hertel exophthalmometry measurements in routine ophthalmic practice.
Instituto de Oftalmología Fundación Conde de Valenciana is the lead sponsor of 45 studies on the registry; 10 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Adult Mexican participants (≥18 years) recruited from the Ophthalmology Department who meet the eligibility criteria. Participants with and without systemic diseases will be included to establish normative Hertel exophthalmometry values and evaluate their association with demographic characteristics and systemic conditions.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Adult Mexican participants undergoing standardized Hertel exophthalmometry and collection of demographic and medical history information for the establishment of normative exophthalmometric values and evaluation of associated factors.
Diagnostic Test: Hertel Exophthalmometry
Standardized bilateral Hertel exophthalmometry performed using a Hertel exophthalmometer to measure globe protrusion.
Hertel Exophthalmometry Value
Bilateral Hertel exophthalmometry measurements (millimeters) obtained using a standardized Hertel exophthalmometer. Normative values will be estimated and summarized for the study population.
Time frame: At baseline
Plan to share: Undecided
No publications or documents are linked to this record.
Started Apr 2026 (actual). Primary completion is estimated for Dec 2026, 8 months after the start.
How these figures are worked out, and which studies are left out of them.
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
Contact study teamGet an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Instituto de Oftalmología Fundación Conde de Valenciana