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RecruitingNCT07684131Ewall Obs 2022Updated Jul 6, 2026

EWALL-PH OBSERVARTORY 2022

An observational study in Acute Lymphoblastic Leukemia, sponsored by Versailles Hospital. Recruiting at 23 sites in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-07-06.

Sponsored by Versailles Hospital · Observational

From the registry’s dates

  • Started Jan 2024; still recruiting 2 years 8 months later.
Study type
Observational
Model
Cohort
Time perspective
Other
Enrollment
100
Ages
18 Years and older
Sex
All
01

Study summary

An observatory for patients aged 18 years and over with Philadelphia chromosome positive (Ph+ or BCR::ABL1) acute lymphoblastic leukemia (ALL) and treated with the combination of BCR::ABL1 inhibitors and chemotherapy and/or corticosteroids and/or a monoclonal antibody.

02

Conditions studied

  • Acute Lymphoblastic Leukemia
03

In context

Precursor Cell Lymphoblastic Leukemia-Lymphoma

2,061 studies on the registry are indexed under Precursor Cell Lymphoblastic Leukemia-Lymphoma; 490 are open to participants now.

This study's planned enrollment of 100 is below the median of 120 across 300 observational studies indexed under Precursor Cell Lymphoblastic Leukemia-Lymphoma.

Browse Precursor Cell Lymphoblastic Leukemia-Lymphoma studies →

Lead sponsor

Versailles Hospital is the lead sponsor of 74 studies on the registry; 17 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Acute Lmphoblastic Leukaemia with Philadelphia chromosome or BCR::ABL1 positive

Inclusion criteria

  1. Male or female patients ≥ 18 years
  2. Philadelphia chromosome or BCR::ABL1 positive acute lymphoblastic leukaemia
  3. Treatment with the combination of BCR::ABL1 inhibitors and chemotherapy and/or corticotherapy and/or a monoclonal antibody

Exclusion criteria

Exclusion Criteria:

  1. Patients deceded and having previously refused data collection
  2. Not included in a prospective clinical trial
05

Study design

Observational model
Cohort
Time perspective
Other
Enrollment
100 participants (estimated)
Target follow-up
5 Years
Patient registry
Yes
06

What researchers measure

Primary outcomes

  1. Overall survival by 12 months

    Time frame: 12 months

Secondary outcomes

  1. overal survival by 36 months

    Time frame: 36 months

  2. proportion of complete remission

    Time frame: 36 months

  3. the molecular response defined by BCR//ABL1/ABL1 ratio in bone marrow and/or peripheral blood

    Time frame: 36 months

  4. the molecular response defined by IGTR quantification proportion in bone marrow and/or peripheral blood

    Time frame: 36 months

  5. Event free survival

    Time frame: 36 months

  6. Relapse free survival

    Time frame: 36 months

  7. the incidence ofBCR..ABL1 TK mutations

    Time frame: 36 months

  8. treatment tolerance

    Time frame: 36 months

  9. Death during induction

    Time frame: 2 months

  10. Death in complete remission

    Time frame: 36 months

07

Study locations

7 of 23 sites recruiting
  • Groupe hospitalier sud
    Amiens, France
    • amandine charbonnie, md · Contact
    Not yet recruiting
  • CHU Angers
    Angers, France
    • aline schmidt, md · Contact
    Not yet recruiting
  • CH de la cote basque
    Bayonne, France
    • claudie capdupuy, MD · Contact
    Not yet recruiting
  • CHU Bordeaux
    Bordeaux, France
    • Thibaut Leguay, MD · Contact
    Recruiting
  • Hopital Militaire Percy
    Clamart, France
    • jean valère Malfuson, MD · Contact
    Not yet recruiting
  • CHU clermont ferrand
    Clermont-Ferrand, France
    • victoria cacheux, MD · Contact
    Recruiting
  • Centre Hospitalier sud francilien
    Corbeil-Essonnes, France
    • Stephanie Haiat, MD · Contact
    Recruiting
  • CHU de grenoble
    Grenoble, France
    • martin carre, md · Contact
    Not yet recruiting
  • CHU Sud Réunion
    La Réunion, France
    • quentin cabrera, md · Contact
    Not yet recruiting
  • CH Versailles
    Le Chesnay, France
    • Philippe Rousselot, MD · Contact
    Recruiting
  • CH Le Mans
    Le Mans, France
    • nathalie denizon, MD · Contact
    Recruiting
  • Chu de Lille
    Lille, France
    • valérie Coiteux, md · Contact
    Not yet recruiting
  • Hopital de la conception
    Marseille, France
    • julien colle, md · Contact
    Not yet recruiting
  • Institut Paoli Calmettes
    Marseille, France
    • Aude Charbonnier, MD · Contact
    Not yet recruiting
  • CHRU de Nancy
    Nancy, France
    • gabrielle roth guepin, md · Contact
    Not yet recruiting
  • Centre Antoine Lacassagne
    Nice, 06189, France
    • Lauris Gastaud · Contact
    Not yet recruiting
  • Hopital Cochin
    Paris, France
    • lise willems, md · Contact
    Not yet recruiting
  • Hopital necker
    Paris, France
    • felipe suarez, MD · Contact
    Recruiting
  • Hopital St Louis
    Paris, France
    • emmaunel Raffoux, md · Contact
    Recruiting
  • CH de Lyon
    Pierre-Bénite, France
    • marie balsat, MD · Contact
    Not yet recruiting
  • CH St Etienne
    Saint-Etienne, France
    • Emmanuelle Tavernier, md · Contact
    Not yet recruiting
  • ICANS
    Strasbourg, France
    • karin bilger, MD · Contact
    Not yet recruiting
  • Hopital de Purpan
    Toulouse, France
    • Francoise huguet, MD · Contact
    Not yet recruiting
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jul 6, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT07684131
Lead sponsor
Versailles Hospital
Responsible party
Philippe ROUSSELOT (Professor, Versailles Hospital) — Principal investigator
First posted
Jul 6, 2026
Start date
Jan 15, 2024
Primary completion
Jun 15, 2027 (estimated)
Completion
Dec 31, 2027 (estimated)
Last update
Jul 6, 2026

Study contacts

Sandrine Roux
Contact
sroux@ght78sud.fr
+33139239777

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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