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Not yet recruitingNCT07666230CBS-IMSUpdated Jun 24, 2026

Personalized Antibiotic Therapy - Point-of-Care Determination of Blood Levels of Beta-Lactam Antibiotics Using Coated-Blade-Spray Ion Mobility Spectrometry

An observational study in Bacterial Infections, sponsored by Dr. T. Perl. Not yet recruiting. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-06-24.

Sponsored by Dr. T. Perl · Observational

Study type
Observational
Model
Case-only
Time perspective
Prospective
Enrollment
200
Ages
18 Years and older
Sex
All
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Study summary

A new analytical method for determining beta-lactam antibiotic concentrations in the blood of intensive care patients is to be evaluated. Patients receive antibiotic therapy with beta-lactam antibiotics in the general surgery intensive care unit. Blood samples are collected daily for routine clinical testing; a portion of these samples is used for the new method. The antibiotic levels, routinely measured using the gold standard, are documented and used as a reference point. The goal of the study is to establish a rapid and cost-effective method for determining beta-lactam antibiotic levels, which will subsequently enable rapid dose adjustment.

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Conditions studied

  • Bacterial Infections

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In context

Bacterial Infections

658 studies on the registry are indexed under Bacterial Infections; 100 are open to participants now.

This study's planned enrollment of 200 is close to the median of 200 across 229 observational studies indexed under Bacterial Infections.

Browse Bacterial Infections studies →

Lead sponsor

This is the only study on the registry with Dr. T. Perl as lead sponsor.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Patents that are treated with beta-lactam antibiotics in the ICU or IMC unit of the Department of General Surgery at UMG

Inclusion criteria

  • Valid informed consent form (prospective, retrospective, or provided by a legal representative)
  • Antibiotic therapy with a beta-lactam antibiotic in the intensive care unit or intermediate care unit of the Department of General Surgery at UMG

Exclusion criteria

Exclusion Criteria:

  • Patients without a valid informed consent form
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Study design

Observational model
Case-only
Time perspective
Prospective
Enrollment
200 participants (estimated)
Patient registry
No
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What researchers measure

Primary outcomes

  1. Blood levels of beta-lactam antibiotics

    Blood levels of beta-lactam antibiotics are measured both through routine clinical testing and using the newly developed analytical method. Blood samples are collected once a day for this purpose. Changes in blood levels are monitored over several days.

    Time frame: Daily, approximately 5-10 days from start of anibiotic therapy (and enrollment) to the end of antibiotic therapy

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Study locations

No study locations are listed for this record.

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References and documents

Individual participant data

Plan to share: Undecided

No publications or documents are linked to this record.

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jun 24, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT07666230
Lead sponsor
Dr. T. Perl
Responsible party
Dr. T. Perl (PD Dr. Thorsten Perl, University of Göttingen) — Sponsor-investigator
First posted
Jun 24, 2026
Start date
Sep 2026 (estimated)
Primary completion
May 2029 (estimated)
Completion
May 2029 (estimated)
Last update
Jun 24, 2026

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is not yet recruiting, as verified in Jun 2026. You cannot join it, but the record below documents what was studied.

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