An interventional study of Bupivacaine and Prilocaine in Intrathecal Injection, Hyperbaric Prilocaine and Hyperbaric Bupivacaine, sponsored by Helwan University. Completed at 1 site in Egypt. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2026-06-24.
Sponsored by Helwan University · Not applicable, Interventional, and Treatment
This study aims to compare the intrathecal injection of hyperbaric prilocaine 2% versus hyperbaric bupivacaine 0.5% in cystoscopy procedures.
Cystoscopy is a short surgical procedure in the field of urology that is very frequently performed. Spinal anesthesia (SA) is the choice because it has an easy implementation technique, fast onset, and low complications compared to general anesthesia.
One of the spinal anesthetic regimens often used is 0.5% hyperbaric bupivacaine, which has a two-segment regression time of around 65 minutes and requires 164 minutes for complete regression to the sacral dermatomes. However, bupivacaine, when used for relatively short procedures, causes various disadvantages including prolonged effects.
Prilocaine is an alternative to bupivacaine in short surgical procedures, including cystoscopy. It has a profile similar to lidocaine but with less neurotoxicity.
Helwan University is the lead sponsor of 69 studies on the registry; 16 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Contraindications to SA including :-
Patients received 0.5% bupivacaine hyperbaric (2.5 ml) + fentanyl 25 µg (0.5 ml).
Drug: Bupivacaine
Patients received hyperbaric 2% prilocaine (2.5 ml) + fentanyl 25 µg (0.5 ml).
Drug: Prilocaine
Patients received 0.5% bupivacaine hyperbaric (2.5 ml) + fentanyl 25 µg (0.5 ml).
Patients received hyperbaric 2% prilocaine (2.5 ml) + fentanyl 25 µg (0.5 ml).
Recovery time
Recovery time defined as the time required until the patient is ready for discharge.
Time frame: Till discharge (Up to 4 hours)
Incidence of side effects
Incidence of side effects such as hypotension, bradycardia, nausea, vomiting, pruritus, and urinary retention were recorded.
Time frame: 24 hours postoperatively
Noninvasive Blood pressure
Noninvasive Blood pressure was monitored every 3 min for the first 15 minutes.
Time frame: Till discharge from hospital (Up to 2 hours)
Heart rate
Heart rate was monitored every 3 min for the first 15 minutes.
Time frame: Till discharge from hospital (Up to 2 hours)
Degree of patient satisfaction
Degree of patient satisfaction was assessed on a 4-point scale (1, excellent; 2, good; 3, fair; 4, poor).
Time frame: 24 hours postoperatively
Plan to share: Yes — The data will be available upon a reasonable request from the corresponding author after the end of study for one year.
Supporting information: Study protocol
No publications or documents are linked to this record.
This study is completed, as verified in Jun 2026. You cannot join it, but the record below documents what was studied.
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Helwan University