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CompletedNCT07662187Updated Jun 29, 2026

Endometrial Cavity After Conservative Management of PAS Patients by Hysteroscopy

An interventional study of Resection and reconstruction and Cervical eversion and pouch closure in Uterine Cavity, Conservative Management and Placenta Accreta, sponsored by Sohag University. Completed at 1 site in Egypt. Open to female participants aged 20 Years to 40 Years. Per ClinicalTrials.gov, last updated 2026-06-29.

Sponsored by Sohag University · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Registered 2 years after the study started (first participant enrolled May 2024, registered Jun 2026).
Phase
Not applicable
Study type
Interventional
Enrollment
150
Allocation
Randomized
Ages
20 Years to 40 Years
Sex
Female
01

Study summary

This study aimed to evaluate the endometrial cavity by hysteroscopy after different conservative management of placenta accrete spectrum (PAS), that has impact on the future fertility outcome and menstrual pattern of patients.

Read the detailed description

Placenta Accreta Spectrum is usually associated with maternal morbidity and mortality. The morbidly adherent placenta spectrum includes, placenta accreta when the placenta invades the endometrium beyond Nitabuch's layer of decidua basalis, placenta increta when the placenta invades the myometrium, and placenta percreta when the placenta invades the uterine serosa.

The risk factors of PAS include previous caesarean section (CS), previous myomectomy, placenta previa, and damage of Nitabuch's layer following intrauterine infection and/or endometrial curettage.

02

Conditions studied

  • Uterine Cavity
  • Conservative Management
  • Placenta Accreta

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03

In context

Placenta Accreta

150 studies on the registry are indexed under Placenta Accreta; 40 are open to participants now.

This study's enrollment of 150 is above the median of 70 across 67 interventional studies indexed under Placenta Accreta.

Browse Placenta Accreta studies →

Lead sponsor

Sohag University is the lead sponsor of 1,230 studies on the registry; 636 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
20 Years to 40 Years
Sexes eligible
Female
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Age from 20 to 40 years.
  • Pregnant women more than 28 weeks have a desire to preserve future fertility.
  • Diagnosis of Placenta accreta spectrum (PAS) was evaluated by 2 D grey scale ultrasound and Doppler study of invasion of the placenta.
  • History of at least previous caesarean section (CS) or any intrauterine operation like myomectomy.
  • Females with history of different conservatives management methods of PAS in last three months.

Exclusion criteria

Exclusion Criteria:

  • Non placenta accreta spectrum and primigravida.
  • Those who have congenital anomalies in the uterus.
  • Those with bleeding tendency.
  • Those women that had hysterectomy as a radical surgery.
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Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
150 participants (actual)

Study arms

  • Experimental
    Group I

    Patients underwent resection and reconstruction.

    Procedure: Resection and reconstruction

  • Experimental
    Group II

    Patients underwent cervical eversion and pouch closure.

    Procedure: Cervical eversion and pouch closure

  • Experimental
    Group III

    Patients underwent anterior and posterior sutures.

    Procedure: Anterior and posterior sutures

Interventions

  • ProcedureResection and reconstruction

    Patients underwent resection and reconstruction.

  • ProcedureCervical eversion and pouch closure

    Patients underwent cervical eversion and pouch closure.

  • ProcedureAnterior and posterior sutures

    Patients underwent anterior and posterior sutures.

06

What researchers measure

Primary outcomes

  1. Number of participants with restoration of the endometrial cavity assessed by office hysteroscopy

    Assessment of endometrial cavity restoration by office hysteroscopy 3 months after conservative management of placenta accreta spectrum.

    Time frame: 3 months after cesarean section

07

Study locations

1 site
  • Sohag University
    Sohag, 82511, Egypt
08

References and documents

Individual participant data

Plan to share: Yes — The data will be available upon a reasonable request from the corresponding author after the end of study for one year.

Supporting information: Study protocol

Time frame: After the end of study for one year.

Access criteria: The data will be available upon a reasonable request from the corresponding author.

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jun 29, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT07662187
Lead sponsor
Sohag University
Responsible party
Rania Mahmoud Ahmed Elkhalily (Lecturer of Obstetrics and Gynecology, Faculty of Medicine, Sohag University, Sohag, Egypt., Sohag University) — Principal investigator
First posted
Jun 23, 2026
Start date
May 13, 2024
Primary completion
Jun 1, 2026
Completion
Jun 1, 2026
Last update
Jun 29, 2026

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jun 2026. You cannot join it, but the record below documents what was studied.

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