An interventional study of Compression and Contraction in Muscle Oxygenation, sponsored by Icahn School of Medicine at Mount Sinai. Suspended at 1 site in United States. Open to participants aged 20 Years to 64 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-09-08.
Sponsored by Icahn School of Medicine at Mount Sinai · Not applicable, Interventional, and Basic science
Demonstration of soft tissue hypoxia on MRI using external compression and muscle contraction.
Participant will undergo a single MRI examination. Standard orthopedic Sarmiento brace/ shell applied to participant's arm. Inside the brace will be a standard blood pressure cuff with a standard brace soft foam attached; blood pressure cuff will be partially inflated. Participant will also be asked to lift MRI compatible 10 lb. weight. Muscle oxygenation will be actively measured using MRI. No medications are being given, and no invasive devices are being used.
Icahn School of Medicine at Mount Sinai is the lead sponsor of 764 studies on the registry; 181 are open to participants now.
Of its 121 completed or terminated interventional studies of FDA-regulated products, 82 (68%) have results posted.
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Exclusion Criteria:
Participant will undergo a single MRI examination of arm with no contrast.
Procedure: Compression and Contraction
Standard orthopedic Sarmiento brace/ shell applied to participant's arm. Inside the brace will be a standard blood pressure cuff with a soft foam attached. Pressure will be applied intermittently with blood pressure cuff. Participant will also be asked to lift MRI compatible 10 lb. weight.
Muscle oxygen level
Using functional MRI to evaluate effect of muscle compression on muscle oxygen. Demonstrating statistically significant change in muscle oxygen in tissues with application of tissue compression and muscle contraction compared to the same, non-compressed tissues with only muscle contraction
Time frame: Day 1, during procedure
Deep tissue oxygen level
Using functional MRI to evaluate the effect of muscle compression and contraction on deep tissue oxygen. Demonstrate statistically greater decreased tissue oxygenation in the deep soft tissues compared to the superficial tissues below the deforming element, during application of tissue compression, during muscle contraction as well during application of tissue compression and muscle contraction.
Time frame: Day 1, during procedure
Plan to share: No — There is no staff available to manage data sharing
No publications or documents are linked to this record.
This study is suspended, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.
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Icahn School of Medicine at Mount Sinai