An interventional study of Diet high in UPF and Diet low in UPF in Cardiometabolic Risk Factors, Microbiota and Diet Interventions, sponsored by Göteborg University. Recruiting at 1 site in Sweden. Open to participants aged 20 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-08-24.
Sponsored by Göteborg University · Not applicable, Interventional, and Prevention
Ultra-processed food (UPF) intake has been related to negative health effects and increased energy intake in previous intervention studies. Thus, previous studies have seen weight gain from higher UPF intake which obscures the potential to see effects on cardiometabolic biomarkers, independent of weight changes. The overall aim of this project is to study the causal effects of a high UPF diet, compared to a nutrient-matched low UPF diet, on appetite and cardiometabolic health in a weight-stable context.
Göteborg University is the lead sponsor of 265 studies on the registry; 46 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Diet high in UPF, followed by a diet low in UPF
Other: Diet high in UPF · Other: Diet low in UPF
Diet low in UPF, followed by a diet high in UPF
Other: Diet high in UPF · Other: Diet low in UPF
Diet high in Ultra-processed food (\>80 % of total energy intake)
Diet low in Ultra-processed food (\<20 % of total energy intake)
Leptin
Time frame: Change from baseline to 6 weeks
ApoB
Apolipoprotein B
Time frame: Change from baseline to 6 weeks
Leptin
Time frame: Change from baseline to 2 weeks
ApoB
Apolipoprotein B
Time frame: Change from baseline to 2 weeks
Ghrelin, PYY, cholecystokinin, insulin
Other appetite-regulating hormones
Time frame: Change from baseline to 2 weeks and from baseline to 6 weeks
Blood lipid profile
ApoA1, LDL, HDL, VLDL, total cholesterol, triglycerides, Lp(a)
Time frame: Change from baseline to 2 weeks and from baseline to 6 weeks
Body weight
Time frame: Change from baseline to 2 weeks and from baseline to 6 weeks
Body composition
Fat mass and fat-free mass
Time frame: Change from baseline to 2 weeks and from baseline to 6 weeks
Blood pressure
Diastolic and systolic blood pressure
Time frame: Change from baseline to 2 weeks and from baseline to 6 weeks
Biomarkers of ultra-processed food intake
Measured in blood and urine
Time frame: At 2 weeks and at 6 weeks
Gut microbiome
Change in gut microbial composition and diversity (alpha- and beta)
Time frame: At 2 weeks and 6 weeks
Glucose
Glucose, measured by continuous blood glucose monitoring
Time frame: Continuous during the first 2 weeks
Energy intake
Ad libitum energy intake at standardized test meal
Time frame: Change from baseline to 2 weeks and from baseline to 6 weeks
Subjective appetite
Self-rated appetite before and after a standardized test meal
Time frame: Change from baseline to 2 weeks and from baseline to 6 weeks
Food cravings and eating behavior
Control of Eating Questionnaire, Three Factor Eating Questionnaire, Power of Food Scale
Time frame: Change from baseline to 2 weeks and from baseline to 6 weeks
Oral microbiome
Change in oral microbial composition
Time frame: At 2 weeks and 6 weeks
Compliance
Compliance assessed by food records
Time frame: At 2 weeks and 6 weeks
Sleep
Pittsburgh Sleep Quality Index
Time frame: Change from baseline to 2 weeks and from baseline to 6 weeks
Well-being
WHO-5 Wellbeing Index
Time frame: Change from baseline to 2 weeks and from baseline to 6 weeks
Plan to share: Undecided — Ethical approvals and legal issues must be considered and resolved before data of individuals can be shared.
No publications or documents are linked to this record.
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Göteborg University