An observational study in Transfusion, Trauma Coagulopathy and Mortality, sponsored by Mariah Arif. Completed at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-05-22.
Sponsored by Mariah Arif · Observational
This retrospective cohort study evaluated transfusion practices and outcomes in 137 severely injured trauma patients requiring massive transfusion at a Level I trauma center (2020-2025). This study analyzed balanced transfusion ratios, whole blood (WB) use, thromboelastography (TEG), and adjunctive hemostatic therapies to determine their impact on 30-day mortality and other clinical outcomes.
Mariah Arif is the lead sponsor of 3 studies on the registry; none are open to participants now.
Counted across the registry records on this site, refreshed daily.
Adult trauma patients (≥18 years) presenting directly to the trauma center were eligible for inclusion if they met at least one of the following criteria:
Adult trauma patients (≥18 years) presenting directly to the trauma center were eligible for inclusion if they met at least one of the following criteria:
Exclusion Criteria:
Patients who received whole blood
Patients who did not receive whole blood and instead only blood components
30-day all cause mortality
Time frame: 30 days post-transfusion
in-hospital mortality
Time frame: From date of hospital admission until date of death, assessed up to 60 months
ICU length of stay
Time frame: from date of ICU admission until date of ICU discharge, assessed up to 60 months
Hospital length of stay
Time frame: from admission till discharge or death
Ventilator-free days
Time frame: Within 28 days post-ventilator use
Acute kidney injury
Time frame: Increase in serum creatinine by ≥0.3 mg/dL within 48 hours, or Increase in serum creatinine to ≥1.5 times baseline within 7 days, or Urine output <0.5 mL/kg/hour for 6 hours.
thromboembolic events
deep vein thrombosis, pulmonary embolism, stroke
Time frame: from date of admission up till date of discharge, assessed up to 60 months
Number of participants with multiorgan failure
Multiorgan failure (MOF) was defined as dysfunction or failure of two or more organ systems as assessed by the Sequential Organ Failure Assessment (SOFA) score.
Time frame: From date of hospital admission until date of documented organ failure, assessed unto 60 months
Transfusion related complications
Transfusion related acute lung injury, Transfusion associated circulatory overload
Time frame: Within 6 hours of transfusion
This study is completed, as verified in May 2026. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.