An interventional study of ENYOY and Care As Usual in Psychological Distress, sponsored by Academisch Medisch Centrum - Amsterdam UMC Research BV. Recruiting at 1 site in Netherlands. Open to participants aged 16 Years to 25 Years. Per ClinicalTrials.gov, last updated 2026-10-05.
Sponsored by Academisch Medisch Centrum - Amsterdam UMC Research BV · Not applicable, Interventional, and Prevention
This study, run by Amsterdam UMC in the Netherlands, looks at whether an online mental health platform called ENYOY can help reduce psychological distress in young people aged 16 to 25 who are waiting for mental health care.
Young people can take part if they are experiencing mental health problems and are currently on a waiting list for mental health care. The study lasts 12 months. During this time, participants complete questionnaires four times: at the start of the study and after 3, 6, and 12 months.
After joining the study, participants are randomly placed into one of two groups:
Young people in the intervention group can use the platform for the duration of the study, with three months of guidance from a coach and/or a peer with lived experience with mental health problems. The platform includes activities based on proven psychological methods. These activities help with issues such as low mood, anxiety, sleep problems, and low confidence. Participants also have access to a safe online community where young people can talk, share experiences, and support each other. The community is moderated to keep it safe and supportive.
Taking part may help reduce psychological distress and improve participants' mental health. There are no known risks associated with taking part in this study.
Participant recruitment will take place from May 2026 to December 2027. Final follow-up assessments are expected to be completed by December 2028. The study is funded by ZonMw.
For questions, you can contact Sascha Struijs (s.y.struijs@vu.nl) or Fenna Hellegers (f.hellegers@amsterdamumc.nl).
This study aims to evaluate the (cost-)effectiveness of a digital health platform (ENYOY) in reducing psychological distress among young people experiencing mental health difficulties who are currently on a waiting list for mental health care. Outcomes will be compared between participants who receive access to ENYOY in addition to care as usual and those who receive care as usual alone.
Young people in the Netherlands aged 16 to 25 years who report mental health difficulties and are currently on a waiting list for mental health care services are eligible to participate. Participants will complete self-report questionnaires at four time points (at the start of the study and at 3, 6, and 12 months).
Following the baseline assessment, participants will be randomly allocated to either the intervention condition (ENYOY plus care as usual) or the control condition (care as usual only). Participants in the intervention group will receive access to the ENYOY platform, including guidance for three months from a coach and/or a peer with lived experience with mental health difficulties. The platform provides personalised, self-directed therapeutic content and access to a moderated online peer community. Participants in the control group will continue to receive standard care.
Participation may contribute to a reduction in psychological distress and improvements in mental health outcomes. No adverse health risks are anticipated.
The study is conducted by Amsterdam UMC in the Netherlands. Participant recruitment will take place from May 2026 to December 2027. Final follow-up assessments are expected to be completed by December 2028. This study is funded by ZonMw.
For further information, please contact Sascha Struijs (s.y.struijs@vu.nl) or Fenna Hellegers (f.hellegers@amsterdamumc.nl).
This is the only study on the registry with Academisch Medisch Centrum - Amsterdam UMC Research BV as lead sponsor.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Young people in this group receive access to the ENYOY platform, along with three months of guidance from a coach and/or a peer with lived experience of mental health difficulties, in addition to Care-As-Usual.
Behavioral: ENYOY
Young people in the control condition receive Care As Asual.
Other: Care As Usual
ENYOY is an evidence-based digital mental health platform co-created with young people. It combines four main elements: interactive therapeutic content, guidence by coaches and/or peers with lived experience with mental health complaints, and a moderated online community. The therapeutic content is based on approaches like cognitive behavioral therapy and is tailored into "journeys" that match a young person's needs, such as improving mood, reducing anxiety, or building confidence. Users can explore activities and build a personal toolkit. The online community offers young people a safe social space where they can connect, share experiences, and support each other. Engagement is encouraged through discussions, prompts, and optional anonymous participation. Safety is closely monitored through both human moderation and automated systems that detect risk.
Also known as: MOST
Young people in the control condition receive Care As Usual.
Psychological distress
Psychological distress will be measured using the Clinical Outcomes in Routine Evaluation-10 measurement (Barkham et al., 2013). The minimum score is 0 and the maximum score is 40. Higher scores indicate higher levels of psychological distress.
Time frame: At 3-month follow-up
Psychological distress
Psychological distress will be measured using the Clinical Outcomes in Routine Evaluation-10 measurement (Barkham et al., 2013). The minimum score is 0 and the maximum score is 40. Higher scores indicate higher levels of psychological distress.
Time frame: At 6-, and 12-month follow-up
Functioning
Functioning will be measured using Work and Social Adjustment Scale - youth version (WSAS-Y; Jassi et al., 2020). The minimum score is 0 and the maximum score is 40. Higher scores indicate greater impairment in functioning.
Time frame: at 3-month, 6-month, and 12-month follow-up
Quality of life
Quality of life will be measured using the My Life Tracker measurement (MLT; Kwan et al., 2018). The minimum score is 0 and the maximum score is 100. Higher scores indicate a better quality of life. We will also use the Co-created outcome measure (YAG, YOUTHreach consortium). The minimum score is 0 and the maximum score is 124. Higher scores indicate a higher quality of life.
Time frame: at 3-month, 6-month, and 12-month follow-up
Depression
Depression will be measured using the Patient Health Questionnaire-9 (PHQ-9; Kroenke et al., 2001). The minimum score is 0 and the maximum is 27. Higher scores indicate a higher level of depression.
Time frame: at 3-month, 6-month, and 12-month follow-up
Anxiety
Anxiety will be measured using the Generalized Anxiety Disorder questionnaire-7 (GAD-7; Spitzer et al., 2006). The minimum score is 0 and the maximum score is 21. Higher scores indicate a higher level of anxiety.
Time frame: at 3-month, 6-month, and 12-month follow-up
Self-esteem
Self-esteem will be measured using the Rosenberg Self-Esteem Scale questionnaire (RSES; Rosenberg, 1965). The minimum score is 0 and the maximum score is 30. Higher scores indicate a higher self-esteem.
Time frame: at 3-month, 6-month, and 12-month follow-up
Health economic measure
Health economic measures will be using the EuroQol - 5 Dimensions - 5 Levels measurement (EQ-5D-5L;EuroQol Research Foundation, 2025; Herdman et al., 2011). The minimum score from the vife dimensions is 11111 and the maximum score is 55555. Higer scores indicate a better health status. We will also use a Resource Use Measurement developed by the YOUTHreach consortium to indicate the resourced used by the young person (RUM; YOUTHreach consortium).
Time frame: at 3-month, 6-months, and 12-month follow-up
Social media use
Social media use will be measured using 8 items of the Compulsive Internet Use Scale (CIUS; Meerkerk et al. 2009). The minimum score is 0 and the maximum score is 32. Higher scores indicate a higher social media usage.
Time frame: at 3-month, 6-month, and 12-month follow-up
Lonliness
Lonliness will be measured using the University of California, Los Angeles (UCLA) Loneliness Scale short form (V3; Russell, 1996). The minimum score is 8 and the maximum score is 32. A higher score indicate greater levels of lonliness.
Time frame: at 3-month, 6-month, and 12-month follow-up
Reach
Reach will be measured using the number of individuals consenting to, participating in, initiating ENYOY, and dropping out during the intervention period.
Time frame: at 3-month, 6-month, and 12-month follow-up
Adoption
Adoption will be measured using the number and profile of sites and delivery agents trained and actively delivering ENYOY during the intervention period.
Time frame: at 3-month, 6-month, and 12-month follow-up
Implementation
Implementation will be measured by the extent to which ENYOY components are delivered and used as intended, using structured checklists and platform-derived usage data.
Time frame: at 3-month, 6-month, and 12-month follow-up
Implementation
Implementation will be measured using the User Version of the Mobile Application Rating Scale (uMARS; Stoyanov et al., 2016). The minimum score is 1 and the maximum score is 5. Higher score indicate a higher quality of the application. Additionally, a bespoke ENYOY satisfaction measure will be used.
Time frame: at 3-month, 6-month, and 12-month follow-up
Maintenance
Maintenance will be measured using ENYOY platform-derived usage data and intended continuation of ENYOY use using self-report items.
Time frame: at 3-month, 6-month, and 12-month follow-up
Plan to share: Yes — Pseudonymized research data from the individual research participants will be shared with the YOUTHReach consortium. See attachment for the registration of their study. Sharing IPD with other researchers is possible upon request.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
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