An interventional study of Create Wellness Creatine Gummies and Creatine Monohydrate Powder in Creatine Absorption in Healthy Adults, sponsored by University of Oklahoma. Recruiting at 1 site in United States. Open to participants aged 18 Years to 45 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-05-28.
Sponsored by University of Oklahoma · Not applicable, Interventional, and Basic science
The purpose of this study is to compare blood creatine levels following acute oral supplementation of Create Wellness creatine gummies to creatine monohydrate powder.
To examine and compare acute effects of Create Wellness creatine gummies and creatine monohydrate powder on blood creatine levels.
Prior to the baseline visit, each participant will be sent an electronic version of the informed consent to review participation details. Those interested will complete a phone screening for inclusion/exclusion criteria. If the participant qualifies for the study and is interested in participating, verbal consent will be obtained. An electronic link for written consent and a self-reported medical health history questionnaire will be sent after verbal consent. Each participant will provide electronic written informed consent and complete the health/medical history questionnaire. Following written electronic consent, health history will be reviewed by the research team to confirm eligibility.
Visits 1 \& 2: Participants will be asked to arrive to the laboratory after an 8-hour overnight fast from caloric foods and beverages and having abstained from vigorous exercise, caffeine, alcohol, and tobacco for the previous 24-hours. Anthropometrics (height and weight) and body composition (via multi-frequency bioelectrical impedance analysis) will be obtained upon arrival and a urine sample will be collected to determine acute hydration and pregnancy status for female participants. Blood samples will then be obtained from the antecubital region at baseline and 30-min, 1-hour, 2-hours, 3-hours, 4-hours, and 5-hours following oral ingestion of the assigned supplement. Participants will be randomized to supplement order of Create Wellness creatine gummies (3 gummies, 4.5 grams of creatine monohydrate) or creatine monohydrate powder (4.5 grams creatine monohydrate in 240 mL water). Gastrointestinal surveys will be also be collected. All research visits will take place at the ATHENA Laboratory in the Health and Exercise Science Department at the University of Oklahoma, Norman Campus. All data will be collected by the Principal Investigator and ATHENA Laboratory Research Assistants.
University of Oklahoma is the lead sponsor of 424 studies on the registry; 99 are open to participants now.
Of its 42 completed or terminated interventional studies of FDA-regulated products, 16 (38%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Dietary Supplement: Create Wellness Creatine Gummies · Dietary Supplement: Creatine Monohydrate Powder
Dietary Supplement: Create Wellness Creatine Gummies · Dietary Supplement: Creatine Monohydrate Powder
Create Wellness creatine gummies provide 4.5 grams of creatine monohydrate in a 3 gummy serving size.
4.5 grams of creatine monohydrate powder (Creapure®) dissolved in 240 mL of water.
Peak plasma concentration (Cmax)
Maximum plasma concentration observed.
Time frame: 0 to 5-hours following supplementation.
Time to peak plasma concentration (Tmax)
Time to reach maximum plasma concentration.
Time frame: 0 to 5-hours following supplementation.
Area under the curve (AUC)
Area under the plasma concentration curve.
Time frame: 0 to 5-hours following supplementation.
Plan to share: No
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University of Oklahoma