An interventional study of Moderate-Intensity Intermittent Walking Training (MIWT) in Cardiometabolic Health in Premenopausal and Postmenopausal Women, sponsored by High Institute of Sports and Physical Education of Kef. Not yet recruiting at 1 site in Tunisia. Open to female participants aged 32 Years to 65 Years. Per ClinicalTrials.gov, last updated 2026-04-29.
Sponsored by High Institute of Sports and Physical Education of Kef · Not applicable, Interventional, and Prevention
The goal of this clinical trial is to compare premenopausal and postmenopausal women regarding the effects of a 10-week moderate-intensity intermittent walking training (MIWT) program on aerobic capacity and selected cardiometabolic and inflammatory markers. The main question it aims to answer is: Does a MIWT program induce differential improvements in aerobic capacity, body composition, lipid profile, and inflammatory markers between premenopausal and postmenopausal women?
Participants in the premenopausal group will perform a 10-week MIWT program, three sessions per week. Participants in the postmenopausal group will perform the same 10-week MIWT program, three sessions per week. Each training session consists of 5 repetitions of 6-minute walking (6MWT) at 60-80% of the baseline 6MWT distance, interspersed by 6 minutes of active recovery between repetitions. Body composition, aerobic capacity (6-minute walk test), heart rate, blood pressure, lipid profile (total cholesterol, LDL-C, HDL-C, triglycerides), and C-reactive protein (CRP) will be assessed before and after the intervention in both groups.
In premenopausal and postmenopausal women, differences in cardiometabolic profile, body composition, and aerobic capacity are commonly observed, with postmenopausal women generally presenting higher cardiometabolic risk. Regular physical activity is known to improve these parameters; however, the specific effects of moderate-intensity intermittent walking training (MIWT) on the comparison between premenopausal and postmenopausal women remain insufficiently explored.
The purpose of this study is to compare the effects of a 10-week moderate-intensity intermittent walking training (MIWT) program on aerobic capacity, body composition, cardiometabolic risk factors, and inflammatory markers in premenopausal and postmenopausal women.
Thirty-two women were allocated into a premenopausal group (n = 16) and a postmenopausal group (n = 16). Both groups performed a MIWT program three times per week for 10 weeks. Each training session consisted of 5 repetitions of 6-minute walking (6-minute walk test, 6MWT) performed at 60-80% of the baseline 6MWT distance, interspersed by 6 minutes of active recovery between repetitions.
Body composition, aerobic capacity (6MWT), heart rate, blood pressure, lipid profile (total cholesterol, LDL-C, HDL-C, triglycerides), and C-reactive protein (CRP) were assessed before and after the intervention in both groups to evaluate changes induced by the training program.
High Institute of Sports and Physical Education of Kef is the lead sponsor of 10 studies on the registry; 3 are open to participants now.
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Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
(BMI) > 24.9 kg/m².
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Periods have stopped for good: usually no period for 12 months in a row without another medical reason, sometimes confirmed by a blood test (FSH).
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
A condition in which the immune system attacks the body’s own tissues, such as rheumatoid arthritis, lupus, psoriasis, type 1 diabetes or inflammatory bowel disease.
Immunotherapy studies often leave out active autoimmune disease, and some name exceptions, such as thyroid disease on replacement hormone. Check the exceptions this study lists.
Postmenopausal
Periods have stopped for good: usually no period for 12 months in a row without another medical reason, sometimes confirmed by a blood test (FSH).
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Autoimmune disease
A condition in which the immune system attacks the body’s own tissues, such as rheumatoid arthritis, lupus, psoriasis, type 1 diabetes or inflammatory bowel disease.
Immunotherapy studies often leave out active autoimmune disease, and some name exceptions, such as thyroid disease on replacement hormone. Check the exceptions this study lists.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Participants in the premenopausal group will perform a 10-week moderate-intensity intermittent walking training (MIWT) program, with three supervised sessions per week. Each session consists of 5 repetitions of 6-minute walking (6-minute walk test, 6MWT) performed at 60-80% of the baseline 6MWT distance, interspersed by 6 minutes of active recovery between repetitions. Body composition, aerobic capacity, heart rate, blood pressure, lipid profile, and C-reactive protein will be assessed before and after the intervention.
Behavioral: Moderate-Intensity Intermittent Walking Training (MIWT)
Participants in the postmenopausal group will perform the same 10-week moderate-intensity intermittent walking training (MIWT) program, with three supervised sessions per week. Each session consists of 5 repetitions of 6-minute walking (6-minute walk test, 6MWT) performed at 60-80% of the baseline 6MWT distance, interspersed by 6 minutes of active recovery between repetitions. Body composition, aerobic capacity, heart rate, blood pressure, lipid profile, and C-reactive protein will be assessed before and after the intervention.
Behavioral: Moderate-Intensity Intermittent Walking Training (MIWT)
Participants will perform a 10-week moderate-intensity intermittent walking training (MIWT) program, with three supervised sessions per week. Each session consists of 5 repetitions of 6-minute walking (6-minute walk test, 6MWT) performed at 60-80% of the baseline 6MWT distance, interspersed by 6 minutes of active recovery between repetitions. The same intervention is applied to both premenopausal and postmenopausal women.
Body Mass Index (BMI)
BMI calculated as weight (kg) divided by height squared (m²).
Time frame: Baseline and after the 10 weeks of the training intervention.
Body Fat Percentage
Total body fat measured by digital scale (Tanita BC-533).
Time frame: Baseline and after the 10 weeks of the training intervention.
Waist Circumference
Measured at the narrowest point between the rib cage and iliac crest using a tape measure.
Time frame: Baseline and after the 10 weeks of the training intervention.
Hip Circumference
Measured at the widest point of the hips using a tape measure.
Time frame: Baseline and after the 10 weeks of the training intervention.
C-Reactive Protein (CRP)
Serum CRP concentration (mg/L).
Time frame: Baseline and after the 10 weeks of the training intervention.
Total Cholesterol
Serum total cholesterol concentration (mg/dL).
Time frame: Baseline and after the 10 weeks of the training intervention.
High-Density Lipoprotein (HDL) Cholesterol
Serum HDL cholesterol concentration (mg/dL).
Time frame: Baseline and after the 10 weeks of the training intervention.
Low-Density Lipoprotein (LDL) Cholesterol
Serum LDL cholesterol concentration (mg/dL).
Time frame: Baseline and after the 10 weeks of the training intervention.
Triglycerides
Serum triglyceride concentration (mg/dL).
Time frame: Baseline and after the 10 weeks of the training intervention.
6-Minute Walk Test (6MWT) Distance
Distance walked in 6 minutes on a 30-meter straight corridor.
Time frame: Baseline and after the 10 weeks of the training intervention.
Blood Pressure (Systolic and Diastolic)
Measured using an automated arm cuff (Omron BP652).
Time frame: Baseline and after the 10 weeks of the training intervention.
Resting Heart Rate
Measured using automated device (Omron BP652).
Time frame: Baseline and after the 10 weeks of the training intervention.
Plan to share: No — For confidentiality reasons, all data from this study are available upon request.
No publications or documents are linked to this record.
Start is estimated for May 2026; primary completion for Aug 2026, 2 months later.
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This study is not yet recruiting, as verified in Apr 2026. You cannot join it, but the record below documents what was studied.
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High Institute of Sports and Physical Education of Kef