ClinicalTrials.gg
RecruitingNCT07542184Updated Aug 21, 2026

Nanochon Chondrograft First in Human (FIH) Early Feasibility Study (EFS) - Panama

An interventional study of Nanochon Chondrograft in Knee Cartilage Lesions, sponsored by Nanochon, Inc.. Recruiting at 1 site in Panama. Open to participants aged 22 Years to 60 Years. Per ClinicalTrials.gov, last updated 2026-08-21.

Sponsored by Nanochon, Inc. · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Started Jul 2026; still recruiting 3 months later.
Phase
Not applicable
Study type
Interventional
Enrollment
5
Allocation
Not applicable
Ages
22 Years to 60 Years
Sex
All
01

Study summary

The goal of this First in Human study is to learn if the Nanochon Chondrograft Implant is a safe primary surgical treatment for participants with cartilage lesions in the knee. This study will include males and females between the ages of 22 and 60.

02

Conditions studied

  • Knee Cartilage Lesions

Keywords

  • Knee cartilage lesions
  • Medial femoral condyle lesion
  • Lateral femoral condyle lesion
  • Trochlea articular cartilage lesion
03

In context

Lead sponsor

Nanochon, Inc. is the lead sponsor of 2 studies on the registry; 2 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
22 Years to 60 Years
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Male or female ≥22 years and ≤ 60 years of age
  • MRI knee evaluation completed within 6 months prior to enrollment
  • Participant must be able to read and speak English and/or Spanish
  • Participant must voluntarily sign the REB approved form (ICF)

Exclusion criteria

Exclusion Criteria:

  • Any known systemic cartilage and/or bone disorder, such as, but not limited to, osteoporosis, chondrodysplasia or osteogenesis imperfecta
  • Requires bilateral knee surgery
  • Pregnancy, planning to become pregnant or breast feeding
  • Any significant illness ( cancer of any type) that decreases the probability of the participant's survival to 12 months
  • Known insulin dependent diabetes mellitus
  • treatment (oral or IV) within the past 6 months

Participant is:

  1. receiving workman's compensation
  2. receiving prescription narcotic medication
  3. active with litigation relating to musculoskeletal injuries or disorders
  4. a prisoner or pending incarceration

    • Comorbidities that could impact study participation or results (e.g., disorder, , neuropathic pain or fibromyalgia, restless leg syndrome, active infection, or pain requiring chronic pain management), in the opinion of the investigator at the time of enrollment
    • Significant psychiatric disorders (e.g., major depression, anxiety disorders, bipolar disorder, and schizophrenia)
    • Substance and/or alcohol dependence and/or abuse based on clinical history, physical exam and participant presentation
    • Current participation in another drug or device study that, in the opinion of the investigator at the time of enrollment, would interfere with participation in this study
    • Participant has claustrophobia or implanted metallic devices (e.g., cardiac pacemakers, insulin pumps, nerve stimulators), medically implanted clips or other electronically, magnetically or mechanically activated implants that would contraindicate undergoing an MRI
    • Known allergy or to any device materials.
Terms in these criteria, in plain language(7)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Informed consent

Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.

You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.

Metastases

Cancer that has spread from where it began to other parts of the body. “Metastatic” cancer is cancer that has spread this way.

Corticosteroids (steroids)

Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.

Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.

Autoimmune disease

A condition in which the immune system attacks the body’s own tissues, such as rheumatoid arthritis, lupus, psoriasis, type 1 diabetes or inflammatory bowel disease.

Immunotherapy studies often leave out active autoimmune disease, and some name exceptions, such as thyroid disease on replacement hormone. Check the exceptions this study lists.

HIV

The human immunodeficiency virus, which weakens the immune system.

Many studies now accept people whose HIV is controlled on treatment, judged by the viral load and the CD4 count. Check the limits this study sets.

Hypersensitivity

An allergy, or another reaction of the immune system, to a substance. “Hypersensitivity to the study drug” means a known allergic reaction to it — not every side effect a medicine can have.

Investigational drug or device

A drug or device being studied in a clinical trial.

It may be new, or already approved and being studied for another use, dose or form. Criteria often leave out people who took part in another study of one within a recent period, commonly 30 days or five half-lives.

05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
5 participants (estimated)

Study arms

  • Experimental
    Nanochon Chondrograft

    Mini arthrotomy or arthroscopic surgical implantation of Nanochon Chondrograft

    Device: Nanochon Chondrograft

Interventions

  • DeviceNanochon Chondrograft

    Mini arthrotomy or arthroscopic surgical implantation of Nanochon Chondrograft

    Also known as: Chondrograft

06

What researchers measure

Primary outcomes

  1. Serious Adverse Device Effects

    Absence of Serious Adverse Device Event Effects (SADEs) through Month 12

    Time frame: Month 12

07

Study locations

1 of 1 sites recruiting
  • The Panama Clinic
    Panama City, Provincia de Panamá, Panama
    Recruiting
08

References and documents

Individual participant data

Plan to share: Undecided — Undecided at this time.

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Aug 21, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT07542184
Lead sponsor
Nanochon, Inc.
Responsible party
Sponsor
First posted
Apr 21, 2026
Start date
Jul 30, 2026
Primary completion
Sep 2027 (estimated)
Completion
Sep 2027 (estimated)
Last update
Aug 21, 2026

Study contacts

Chief Clinical Officer
Contact
Heather@Nanochon.com
615-483-7438

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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