An interventional study of Creatine Monohydrate and Creatine Monohydrate in Creatine Supplementation and Exercise Ergogenics, sponsored by Universitas Negeri Malang. Completed at 1 site in Indonesia. Open to male participants aged 19 Years to 25 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-04-16.
Sponsored by Universitas Negeri Malang · Not applicable, Interventional, and Basic science
This study evaluates whether 7-day creatine monohydrate supplementation affects cognitive function after high-intensity interval training (HIIT) in active young men. Twenty participants were assigned to one of four groups: placebo plus exercise, placebo without exercise, creatine 0.1 g/KgBW/day plus exercise, or creatine 0.3 g/KgBW/day plus exercise. Cognitive performance was measured before and after the intervention using visual reaction time, go/no-go visual reaction time, and Trail Making Tests A and B.
This study used a controlled pretest-posttest, four-arm interventional design to examine the effects of short-term creatine monohydrate supplementation on cognitive function after high-intensity interval training (HIIT) in active young men. Twenty participants were allocated into four groups: placebo plus exercise, placebo without exercise, creatine 0.1 g/KgBW/day plus exercise, and creatine 0.3 g/KgBW/day plus exercise. The intervention lasted 7 days.
Participants in the exercise groups completed a bodyweight HIIT protocol consisting of two rounds. Round 1 used 40 seconds of work and 20 seconds of rest, and round 2 used 30 seconds of work and 15 seconds of rest, with 30 seconds of rest between rounds. The session included 14 sequential movements and was preceded by a 5-minute warm-up and followed by a 5-minute cool-down.
Cognitive performance was assessed before and after the intervention using visual reaction time (VRT), go/no-go visual reaction time (GNGVRT), and Trail Making Test Parts A and B. These measures were selected to capture processing speed, inhibitory control, attention, and executive function. The study was approved by the ethics committee of Universitas Negeri Malang, and written informed consent was obtained from all participants.
This is the only study on the registry with Universitas Negeri Malang as lead sponsor.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Participants received placebo supplementation using maltodextrin for 7 days and performed high-intensity interval training.
Drug: Placebo · Behavioral: High Intensity Interval Training
Participants received placebo supplementation using maltodextrin for 7 days without exercise intervention.
Drug: Placebo
Participants received creatine monohydrate supplementation at 0,1 g/KgBW/day for 7 days and performed high-intensity interval training.
Drug: Creatine Monohydrate · Behavioral: High Intensity Interval Training
Participants received creatine monohydrate supplementation at 0,3 g/KgBW/day for 7 days and performed high-intensity interval training.
Drug: Creatine Monohydrate · Behavioral: High Intensity Interval Training
Creatine monohydrate supplementation at a dose of 0,1 g/KgBW/day for 7 days.
Creatine monohydrate supplementation at a dose of 0,3 g/KgBW/day for 7 days.
Placebo supplementation for 7 days
A bodyweight high-intensity interval training program performed in 2 rounds with 40 seconds work and 20 seconds rest in round 1, and 30 seconds work and 15 seconds rest in round 2, with 30 seconds rest between rounds.
Go/No-Go Visual Reaction Time False Alarm Errors
Number of false alarm (commission) errors recorded during the Go/No-Go Visual Reaction Time test. Lower values indicate better inhibitory control.
Time frame: Baseline and Day 7
Go/No-Go Visual Reaction Time
Average response time for correct go trials during the Go/No-Go Visual Reaction Time test, expressed in milliseconds. Lower values indicate faster processing speed.
Time frame: Baseline and Day 7
Trail Making Test Part B Completion Time
Trail Making Test Part B Completion Time
Time frame: Baseline and Day 7
Visual Reaction Time
Simple visual reaction time measured in milliseconds. Lower values indicate faster processing speed.
Time frame: Baseline and Day 7
Trail Making Test Part A Completion Time
Trail Making Test Part A Completion Time
Time frame: Baseline and Day 7
Plan to share: Undecided — The plan for sharing individual participant data has not yet been finalized.
No publications or documents are linked to this record.
This study is completed, as verified in Apr 2026. You cannot join it, but the record below documents what was studied.
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