Phase III Study of HRS-7535 for Hypertension With Overweight or Obesity

1. On the day of signing the informed consent form, the age should be between 18 and 70 years old, with no gender restrictions;
2. When screening and randomizing, the average office blood pressure meets any of the following conditions: ① 140 mmHg ≤ SBP \< 170 mmHg, and DBP \< 110 mmHg; ② 90 mmHg ≤ DBP \< 110 mmHg, and 130 mmHg ≤ SBP \< 170 mmHg;
3. Patients with untreated hypertension, or those who have received stable doses of any or all of the following classes of antihypertensive medications within 30 days prior to screening: 1) angiotensin-converting enzyme inhibitors/angiotensin receptor blockers (ACEI/ARB), 2) thiazides and thiazide-like diuretics, 3) calcium channel blockers. Patients who are currently receiving stable doses of beta blockers (such as metoprolol or atenolol) or mineralocorticoid receptor antagonists (such as spironolactone) and intend to continue these treatments at their current doses may be included in this study;
4. During screening, BMI should be ≥24 kg/m2;

Exclusion Criteria:

1. Having a known secondary cause of hypertension
2. History of previously diagnosed heart failure with reduced ejection fraction (HFrEF);
3. Those who have undergone coronary revascularization within the previous 90 days or plan to undergo it during the trial period;
4. Diagnosed or suspected with type 1 diabetes, special type of diabetes, or secondary diabetes (excluding gestational diabetes);
5. History of acute or chronic pancreatitis, pancreatic injury, acute cholecystitis, or symptomatic/requiring treatment of gallbladder disease (excluding those who have undergone cholecystectomy but are still eligible for enrollment as determined by the investigator);