An interventional study of bioactive composite and nanohybrid resin composite in Tooth Disease, sponsored by Hacettepe University. Not yet recruiting. Open to participants aged 18 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-05-01.
Sponsored by Hacettepe University · Not applicable, Interventional, and Treatment
The clinical performance of a bioactive composite (alkasite-based), a nanohybrid resin composite and a bulk-fill resin composite in class II restorations will be evaluated and compared. After recruiting participants with at least 3 approximal caries lesions, all restorations will be placed by a single clinician. All caries lesions will be removed before restoring. Cavities will be divided into three groups: a bioactive composite [Cention Forte Ivoclar Vivadent, Schaan, Liechtenstein], a nanohybrid resin composite [Tetric N-Ceram2 (Ivoclar Vivadent, Schaan, Liechtenstein)] and a bulk-fill resin composite [Tetric N-PowerFill2 (Ivoclar Vivadent, Schaan, Liechtenstein)], All restorative procedures will be conducted according to manufacturers' instructions. Restorations will be scored using FDI criteria after a week (baseline) 6, 12, 24, 36 and 48 months. Descriptive statistics will be performed using chi-square tests.
79 studies on the registry are indexed under Tooth Diseases; 11 are open to participants now.
This study's planned enrollment of 60 is above the median of 49 across 63 interventional studies indexed under Tooth Diseases.
Browse Tooth Diseases studies →Hacettepe University is the lead sponsor of 1,007 studies on the registry; 214 are open to participants now.
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Exclusion Criteria:
Cention Forte Ivoclar Vivadent, Schaan, Liechtenstein
Device: bioactive composite
Tetric N-Ceram2 (Ivoclar Vivadent, Schaan, Liechtenstein)
Device: nanohybrid resin composite
Tetric N-PowerFill2 (Ivoclar Vivadent, Schaan, Liechtenstein)
Device: bulk-fill resin composite
bioactive composite restoration
nanohybrid resin composite restoration
bulk-fill resin composite restoration
Clinical performances of different restorative systems according to FDI criteria
Two year results according to FDI criteria (scores 1-5, 1-very good, 5-poor/replace)
Time frame: two years
No study locations are listed for this record.
Plan to share: No
No publications or documents are linked to this record.
Start is estimated for Apr 2026; primary completion for Jun 2026, 2 months later.
Of 32 non-industry interventional studies with no phase under Tooth Diseases, half reached primary completion within 8 months of starting (the median), counting those still running; a quarter within 3 and three quarters within 18. This study's planned 2 months is below that.
Counting every sponsor, half of 39 studies reached it within 12 months; a quarter within 4 and three quarters within 42.
How these figures are worked out, and which studies are left out of them.
This study is not yet recruiting, as verified in Apr 2026. You cannot join it, but the record below documents what was studied.
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