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RecruitingNCT07517484Updated May 29, 2026

Light and Anesthesia

An interventional study of eye mask in Light, Anesthesia and Sedation, sponsored by Peking University People's Hospital. Recruiting at 1 site in China. Open to participants aged 18 Years to 64 Years. Per ClinicalTrials.gov, last updated 2026-05-29.

Sponsored by Peking University People's Hospital · Not applicable, Interventional, and Other

From the registry’s dates

  • Primary completion was expected by Jun 2026, 3 months ago, but the record still lists the study as recruiting.
  • Registered 5 months after the study started (first participant enrolled Oct 2025, registered Mar 2026).
  • Started Oct 2025; still recruiting 1 year later.
Phase
Not applicable
Study type
Interventional
Enrollment
66
Allocation
Randomized
Ages
18 Years to 64 Years
Sex
All
01

Study summary

The objective of this clinical trial is to investigate the effect of light exposure on sedation depth during general anesthesia.The primary research questions this study aims to address include:

Does light condition affect the dosage of anesthetic medications during anesthesia? By what mechanism does light exposure exert an influence on anesthesia? Participants will be randomly allocated to either the light-shielded group or the non-light-shielded group.Patients in the light-shielded group will wear an eye shield during anesthesia.

The following data will be recorded for all patients:

Induction drug dosage Induction time Intraoperative anesthetic dosage Emergence time

02

Conditions studied

  • Light
  • Anesthesia
  • Sedation

Keywords

  • light
  • anesthesia
  • sedation depth
03

In context

Lead sponsor

Peking University People's Hospital is the lead sponsor of 584 studies on the registry; 233 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 64 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • a. Age between 18 and 65 years, regardless of gender;
  • b. ASA physical status I-II;
  • c. 18.5 ≤ BMI ≤ 28;
  • d. Signed written informed consent.

Exclusion criteria

Exclusion Criteria:

  • a. Blindness or history of photosensitivity disorders;
  • b. Patients requiring medication for sleep, or with a history of sleep disorders;
  • c. Presence of neurological diseases;
  • d. Pregnancy;
  • e. Severe hepatic or renal dysfunction;
  • f. History of anesthetic drug abuse or alcohol abuse;
  • g. History of adverse anesthesia events (difficult airway, allergy to anesthetic agents).
05

Study design

Phase
Not applicable
Primary purpose
Other
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
66 participants (estimated)

Study arms

  • Experimental
    the light-shielded group

    Patients in the light-shielded group will wear an opaque eye mask 30 minutes prior to induction of general anesthesia and continue to do so until the cessation of sedative medications for anesthesia.

    Device: eye mask

  • No intervention
    the non-light-shielded group

Interventions

  • Deviceeye mask

    Patients in the light-shielded group will wear an opaque eye mask 30 minutes prior to induction of general anesthesia and continue to do so until the cessation of sedative medications for anesthesia.

06

What researchers measure

Primary outcomes

  1. The dose of sedative medications

    The dose of sedative medications required during the induction period in patients

    Time frame: Perioperative

Secondary outcomes

  1. Induction time of anesthesia

    Induction time of anesthesia

    Time frame: Perioperative

  2. total dose of sedative medications

    total dose of sedative medications required to maintain a certain range of anesthetic depth during surgery

    Time frame: during surgery

  3. emergence time

    emergence time after drug discontinuation

    Time frame: Perioperative

07

Study locations

1 of 1 sites recruiting
  • Peking University People's Hospital
    Beijing, 100044, China
    Recruiting
08

References and documents

Publications

  • Boatright JH, Rubim NM, Iuvone PM. Regulation of endogenous dopamine release in amphibian retina by gamma-aminobutyric acid and glycine. Vis Neurosci. 1994 Sep-Oct;11(5):1003-12. doi: 10.1017/s095252380000393x. PubMed 7947393 ↗
  • Szolnoki J, Polaner DM, Eckle T. Diurnal variations in recovery times after general anaesthesia in children. Br J Anaesth. 2018 Oct;121(4):776-786. doi: 10.1016/j.bja.2018.06.027. Epub 2018 Aug 10. PubMed 30236240 ↗
  • Shen JH, Ye M, Chen Q, Chen Y, Zhao HL, Khan A, Yi B, Ning JL, Lu KZ, Gu JT. Effects of circadian rhythm on Narcotrend index and target-controlled infusion concentration of propofol anesthesia. BMC Anesthesiol. 2021 Sep 6;21(1):215. doi: 10.1186/s12871-021-01445-z. PubMed 34488646 ↗
  • Wang D, Huang Y, Wang X, Chen X, Li J, Zhang S, Wu J, Liu D, Ma D, Mei W. Circadian differences in emergence from volatile anaesthesia in mice: involvement of the locus coeruleus noradrenergic system. Br J Anaesth. 2020 Oct;125(4):548-559. doi: 10.1016/j.bja.2020.07.012. Epub 2020 Aug 15. PubMed 32807382 ↗
  • Shao Y, Li Y, Wang N, Xue Y, Wang T, Qiu F, Lu Y, Lan D, Wu H. Effect of daily light exposure on sleep in polar regions: A meta-analysis. J Sleep Res. 2024 Oct;33(5):e14144. doi: 10.1111/jsr.14144. Epub 2024 Jan 22. PubMed 38253963 ↗
  • Ishizawa M, Uchiumi T, Takahata M, Yamaki M, Sato T. Effects of pre-bedtime blue-light exposure on ratio of deep sleep in healthy young men. Sleep Med. 2021 Aug;84:303-307. doi: 10.1016/j.sleep.2021.05.046. Epub 2021 Jun 8. PubMed 34217920 ↗
  • Touitou Y, Reinberg A, Touitou D. Association between light at night, melatonin secretion, sleep deprivation, and the internal clock: Health impacts and mechanisms of circadian disruption. Life Sci. 2017 Mar 15;173:94-106. doi: 10.1016/j.lfs.2017.02.008. Epub 2017 Feb 16. PubMed 28214594 ↗
  • Barger LK, Sullivan JP, Lockley SW, Czeisler CA. Exposure to Short Wavelength-Enriched White Light and Exercise Improves Alertness and Performance in Operational NASA Flight Controllers Working Overnight Shifts. J Occup Environ Med. 2021 Feb 1;63(2):111-118. doi: 10.1097/JOM.0000000000002054. PubMed 33065729 ↗
  • Daurat A, Foret J, Benoit O, Mauco G. Bright light during nighttime: effects on the circadian regulation of alertness and performance. Biol Signals Recept. 2000 Nov-Dec;9(6):309-18. doi: 10.1159/000014654. PubMed 11025337 ↗
  • Dollish HK, Tsyglakova M, McClung CA. Circadian rhythms and mood disorders: Time to see the light. Neuron. 2024 Jan 3;112(1):25-40. doi: 10.1016/j.neuron.2023.09.023. Epub 2023 Oct 18. PubMed 37858331 ↗
  • LeGates TA, Fernandez DC, Hattar S. Light as a central modulator of circadian rhythms, sleep and affect. Nat Rev Neurosci. 2014 Jul;15(7):443-54. doi: 10.1038/nrn3743. Epub 2014 Jun 11. PubMed 24917305 ↗
  • Ramsey DJ, Ramsey KM, Vavvas DG. Genetic advances in ophthalmology: the role of melanopsin-expressing, intrinsically photosensitive retinal ganglion cells in the circadian organization of the visual system. Semin Ophthalmol. 2013 Sep-Nov;28(5-6):406-21. doi: 10.3109/08820538.2013.825294. Epub 2013 Sep 6. PubMed 24010846 ↗
  • Jensen EW, Litvan H, Struys M, Martinez Vazquez P. Pitfalls and challenges when assessing the depth of hypnosis during general anaesthesia by clinical signs and electronic indices. Acta Anaesthesiol Scand. 2004 Nov;48(10):1260-7. doi: 10.1111/j.1399-6576.2004.00521.x. PubMed 15504186 ↗
  • Sear JW. Practical treatment recommendations for the safe use of anaesthetics. Drugs. 1992 Jan;43(1):54-68. doi: 10.2165/00003495-199243010-00006. PubMed 1372860 ↗
  • Shepherd J, Jones J, Frampton G, Bryant J, Baxter L, Cooper K. Clinical effectiveness and cost-effectiveness of depth of anaesthesia monitoring (E-Entropy, Bispectral Index and Narcotrend): a systematic review and economic evaluation. Health Technol Assess. 2013 Aug;17(34):1-264. doi: 10.3310/hta17340. PubMed 23962378 ↗
  • Bruhn J, Myles PS, Sneyd R, Struys MM. Depth of anaesthesia monitoring: what's available, what's validated and what's next? Br J Anaesth. 2006 Jul;97(1):85-94. doi: 10.1093/bja/ael120. Epub 2006 Jun 2. PubMed 16751211 ↗

Individual participant data

Plan to share: No — To protect patient privacy and ensure the security of clinical data, the individual participant data (IPD) collected in this study will be used only for scientific analysis and publication related to this trial. No public disclosure, sharing, or uploading to public repositories is planned. Therefore, IPD will not be made available.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 29, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT07517484
Lead sponsor
Peking University People's Hospital
Responsible party
Yi Feng, MD (Chief of Anesthesiology, Peking University People's Hospital) — Principal investigator
First posted
Apr 8, 2026
Start date
Oct 3, 2025
Primary completion
Jun 30, 2026 (estimated)
Completion
Jun 30, 2026 (estimated)
Last update
May 29, 2026

Study contacts

Yi Feng, Ph.D
Contact
doctor_yifeng@sina.com
010-88325590
Xiaoyan Li, Ph.D
Contact
2411110461@bjmu.edu.cn
18810599681

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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