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RecruitingNCT07505914Updated Apr 1, 2026

Effects of Breathing Exercises on Cognition in Older Adults

An interventional study of Balance Training Program and Inspiratory Muscle Training in Older Adults (65 Years and Older), Cognition and Balance Control in Elderly, sponsored by Istanbul University - Cerrahpasa. Recruiting at 1 site in Turkey (Türkiye). Open to participants aged 65 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-04-01.

Sponsored by Istanbul University - Cerrahpasa · Not applicable, Interventional, and Supportive care

Phase
Not applicable
Study type
Interventional
Enrollment
40
Allocation
Randomized
Ages
65 Years and older
Sex
All
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Study summary

The goal of this interventional clinical trial is to investigate the effects of breathing exercises added to balance training on cognitive function in individuals aged 65 years and older.

The main questions it aims to answer are:

Do breathing exercises affect cognition? Do different breathing exercises affect cognition in different ways?

Researchers will administer two different breathing protocols and evaluate cognition before and after each protocol.

Participants will take part in an 8-week program consisting of sessions that include 30 minutes of balance-based exercises and 15 minutes of breathing exercises. Sessions will be held twice weekly under the supervision of a physical therapist.

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Conditions studied

  • Older Adults (65 Years and Older)
  • Cognition
  • Balance Control in Elderly
  • Fall Prevention in Healthy Aging
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In context

Lead sponsor

Istanbul University - Cerrahpasa is the lead sponsor of 680 studies on the registry; 207 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
65 Years and older
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • Adults aged 65 years and older
  • Able to walk independently
  • Suitable for light to moderate physical activity
  • Willing and able to attend 2 sessions per week for 8 weeks

Exclusion criteria

Exclusion Criteria:

  • Underwent surgery within the last 6 months
  • Currently participating in another structured rehabilitation program
  • Neurological disorders that significantly restrict mobility (e.g., Parkinson's disease, stroke)
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Study design

Phase
Not applicable
Primary purpose
Supportive care
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Double (Participant, Care provider)
Enrollment
40 participants (estimated)

Study arms

  • Experimental
    Inspiratory Muscle Training

    Other: Balance Training Program · Other: Inspiratory Muscle Training

  • Experimental
    Breathing Exercises

    Other: Balance Training Program · Other: Breathing Exercise Program

Interventions

  • OtherBalance Training Program

    A structured balance-based exercise program (30 minutes per session) designed to reduce fall risk and improve functional performance.

  • OtherInspiratory Muscle Training

    Training performed using a threshold device to strengthen inspiratory muscles for 15 minutes with intensity set individually and progressively adjusted.

  • OtherBreathing Exercise Program

    Breathing exercises aimed at improving lung function and respiratory health, including diaphragmatic breathing and pursed-lip breathing. Exercises will be performed for 15 minutes

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What researchers measure

Primary outcomes

  1. Montreal Cognitive Assessment (MoCA)

    The Montreal Cognitive Assessment (MoCA) is used to assess global cognitive function. The total score ranges from 0 to 30, with higher scores indicating better cognitive performance.

    Time frame: From enrollment to the end of intervention at 8 weeks

Secondary outcomes

  1. Spirometry Parameters (FEV1, FVC, FEV1/FVC Ratio)

    Spirometry will be used to assess pulmonary function, including forced expiratory volume in one second (FEV1), forced vital capacity (FVC), and the FEV1/FVC ratio. Higher values indicate better pulmonary function.

    Time frame: From enrollment to the end of intervention at 8 weeks

  2. Maximal Inspiratory and Expiratory Pressures (MIP/MEP)

    Respiratory muscle strength will be assessed using maximal inspiratory pressure (MIP) and maximal expiratory pressure (MEP) measurements. Higher values indicate greater respiratory muscle strength.

    Time frame: From enrollment to the end of intervention at 8 weeks

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Study locations

1 of 1 sites recruiting
  • Müzeyyen Keçeli Aile Sağlığı Merkezi
    Istanbul, Turkey (Türkiye)
    Recruiting
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References and documents

Publications

  • Johannknecht M, Kayser C. The influence of the respiratory cycle on reaction times in sensory-cognitive paradigms. Sci Rep. 2022 Feb 16;12(1):2586. doi: 10.1038/s41598-022-06364-8. PubMed 35173204 ↗
  • Vanutelli ME, Grigis C, Lucchiari C. Breathing Right... or Left! The Effects of Unilateral Nostril Breathing on Psychological and Cognitive Wellbeing: A Pilot Study. Brain Sci. 2024 Mar 23;14(4):302. doi: 10.3390/brainsci14040302. PubMed 38671954 ↗
  • Song F, Ding K, Sun W, Huang Q, Jiang R, Xiang H, Sun M. Effects of 12 weeks of Head-Down Strong Abdominal Breathing Training on Gait and Cognitive Function in Patients with Chronic Obstructive Pulmonary Disease. Int J Chron Obstruct Pulmon Dis. 2025 May 1;20:1347-1359. doi: 10.2147/COPD.S514766. eCollection 2025. PubMed 40330797 ↗
  • Zelano C, Jiang H, Zhou G, Arora N, Schuele S, Rosenow J, Gottfried JA. Nasal Respiration Entrains Human Limbic Oscillations and Modulates Cognitive Function. J Neurosci. 2016 Dec 7;36(49):12448-12467. doi: 10.1523/JNEUROSCI.2586-16.2016. PubMed 27927961 ↗
  • Braendholt M, Kluger DS, Varga S, Heck DH, Gross J, Allen MG. Breathing in waves: Understanding respiratory-brain coupling as a gradient of predictive oscillations. Neurosci Biobehav Rev. 2023 Sep;152:105262. doi: 10.1016/j.neubiorev.2023.105262. Epub 2023 Jun 3. PubMed 37271298 ↗

Individual participant data

Plan to share: No

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Apr 1, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT07505914
Lead sponsor
Istanbul University - Cerrahpasa
Responsible party
Deema Almurad (Principal Investigator, Istanbul University - Cerrahpasa) — Principal investigator
First posted
Apr 1, 2026
Start date
Mar 20, 2026 (estimated)
Primary completion
Dec 2026 (estimated)
Completion
Dec 2026 (estimated)
Last update
Apr 1, 2026

Study contacts

Deema Almurad
Contact
deemaalmurad@gmail.com
00905010492000

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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