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CompletedNCT07495696MEGA L112Updated Mar 27, 2026

Possibilities of Recording Changes in Various Health Parameters by Measuring Bioimpedance With the mBCA 555 During the Use of Products From the L112 Product Range

An observational study in Overweight, sponsored by Certmedica International GmbH. Completed at 1 site in Germany. Open to participants aged 18 Years to 80 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-03-27.

Sponsored by Certmedica International GmbH · Observational

Study type
Observational
Model
Case-only
Time perspective
Prospective
Enrollment
41
Ages
18 Years to 80 Years
Sex
All
01

Study summary

As a combination of medical products (mBCA scale, mBCA standing aid, length measuring rod and cloud-based software), the seca mBCA 555 makes it possible to determine nutritional status, energy consumption and body water distribution. For this purpose, weight, height and bioimpedance data are measured and further body composition parameters are determined. In addition, changes in muscle mass and fat mass resulting from physical training can be assessed. It is a class IIa medical device.

The L112 product range serves as a lipid binder for weight reduction and weight maintenance with an accompanying LDL cholesterol-lowering effect. It is a class III medical device.

The aim of this study is to explore which early changes in body composition and other health parameters accessible by bioimpedance measurement can be detected with the mBCA 555 measurement method when taking the L112 product series even before weight reduction.

If it were possible to detect changes in health parameters that can be recorded with the mBCA 555 at an early stage while taking the L112 product range, a strategy could be developed to motivate users. In the successful treatment of obesity, patient compliance and motivation are crucial due to the necessary dietary and lifestyle changes. Early successes or indications of a good development of the mBCA health parameters, which are visible even before a relevant change in weight, can serve as a motivational aid and lead to better success in weight reduction. This exploratory study aims to identify these parameters as a basis for further clinical studies.

Read the detailed description

Research question:

What changes in body composition and other health parameters accessible through bioimpedance measurement can be measured when taking the L112 product range before weight loss?

02

Conditions studied

  • Overweight

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Keywords

  • formoline L112
  • Bioimpedance scale
  • Overweight
  • Body composition
03

Who can participate

Ages eligible
18 Years to 80 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

Aschaffenburg and surrounding area

Inclusion criteria

  • Declaration of consent
  • Privacy policy
  • Adults > 18 years of age (women and men)
  • Nutritional profile: High-fat diet / mixed-fat diet
  • Contraception for participants who could become pregnant

Exclusion criteria

Exclusion Criteria:

  • known allergy to crustaceans or any of the ingredients
  • underweight (BMI \< 18,5 kg/m²),
  • pregnant women
  • breastfeeding mothers
  • chronic constipation, intestinal obstruction etc.
  • serious gastrointestinal diseases and condition after operations on the gastrointestinal tract
  • Long-term use of medication with the exception of contraceptives
  • Intake of formoline L112, formoline L112 EXTRA, Sterolsan, Liporeform protect, Liposlim nutritabs in the last 4 weeks
  • Monaten If taken for weight reduction: Weight reduction measure in the last 3 months
  • Pronounced fluctuations in body weight in the last 3 months
  • Electrical implants such as pacemakers
  • Active prostheses
  • Use of portable electronic medical devices such as infusion pumps or ECG devices
  • People with cardiac arrhythmia
  • Acute illnesses
  • Chronic diseases other than controlled diabetes mellitus
  • Amputated limbs
  • Artificial joints
  • Metal implants with the exception of teeth
  • Alcohol abuse
  • Continuous intake of formoline L112 in the last 4 weeks before the start of the study
04

Study design

Observational model
Case-only
Time perspective
Prospective
Enrollment
41 participants (actual)
Patient registry
No

Groups and cohorts

  • formoline L112 Extra 2 tabletts daily

    For weight control (participants with BMI \< 25), the dose is reduced to 2 tablets daily

    Other: formoline L112 EXTRA

  • formoline L112 Extra 2x2 tabletts daily

    For weight reduction (participants with BMI ≥ 25): 2 x 2 tablets with the two meals with the highest fat content

    Other: formoline L112 EXTRA

Interventions

  • Otherformoline L112 EXTRA

    Taking formoline L112 EXTRA (750 mg tablets) for a duration of 12 weeks: For weight reduction (participants with BMI ≥ 25): 2 x 2 tablets with the two meals with the highest fat content For weight control (participants with BMI \< 25), the dose is reduced to 2 tablets daily.

05

What researchers measure

Primary outcomes

  1. BMI (Body-Mass-Index)

    Measurement with seca mBCA 555, unit kg/m2

    Time frame: 12 weeks

  2. Body weight

    Measurement with seca mBCA 555, unit kg

    Time frame: 12 weeks

  3. FMI (Fat-Mass-Index)

    Measurement with seca mBCA 555, unit kg/m2

    Time frame: 12 weeks

  4. FM% (fat-mass percentage)

    Measurement with seca mBCA 555, unit %

    Time frame: 12 weeks

  5. FFMI (fat-free-mass-index)

    measured with seca mBCA bioimpedance scale, unit kg/m2

    Time frame: 12 weeks

  6. SSM (Skeletal muscle mass)

    measured with seca mBCA bioimpedance scale, unit kg

    Time frame: 12 weeks

  7. SMI (Skeletal muscle index)

    measured with seca mBCA bioimpedance scale, unit kg/m2

    Time frame: 12 weeks

  8. Skeletal muscle mass depending on age

    measured with seca mBCA bioimpedance scale, unit kg

    Time frame: 12 weeks

  9. Phase angle

    measured with seca mBCA bioimpedance scale, unit Degree

    Time frame: 12 weeks

  10. Visceral fat

    measured with seca mBCA bioimpedance scale, unit litre

    Time frame: 12 weeks

  11. Skeletal muscle mass index of the extremities

    measured with seca mBCA bioimpedance scale, unit kg/m2

    Time frame: 12 weeks

  12. Waist circumference

    measured manually with meassuring tape, unit cm

    Time frame: 12 weeks

  13. Body Composition Chart

    produced by seca analytics from seca mBCA bioimpedance measurements of fat mass and skeletal muscle mass.

    Time frame: 12 weeks

  14. Segmental skeletal muscle mass distributed over the 5 segments: Arm right, Arm left, torso, leg right, leg left

    measured with seca mBCA bioimpedance scale, unit kg

    Time frame: 12 weeks

  15. TBW (total body water)

    measured with seca mBCA bioimpedance scale, unit litre

    Time frame: 12 weeks

  16. ECW (extracellular water)

    measured with seca mBCA bioimpedance scale, unit litre

    Time frame: 12 weeks

  17. Water ratio ECW/TBW

    calculated by seca analytics from measured with seca mBCA bioimpedance scale of ECW (extracellular water) and TBW (total body water)

    Time frame: 12 weeks

  18. Bioelectrical impedance vector analysis

    produced by seca analytics from seca mBCA bioimpedance scale measurements concerning body cell mass and hydration status

    Time frame: 12 weeks

  19. TRU Body Score

    calculated by seca analytics from seca mBCA bioimpedance scale measurements of muscle and fat mass, reflecting training status

    Time frame: 12 weeks

06

Study locations

1 site
  • Certmedica International GmbH
    Aschaffenburg, Bavaria 63741, Germany
07

Registry details

Key details

Study ID
NCT07495696
Lead sponsor
Certmedica International GmbH
Collaborators
Seca GmbH & Co. Kg.
Responsible party
Sponsor
First posted
Mar 27, 2026
Start date
Apr 15, 2025
Primary completion
Feb 26, 2026
Completion
Feb 26, 2026
Last update
Mar 27, 2026

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
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