CClinicalTrials.gg
CompletedNCT07474597Updated Mar 17, 2026

Investigation of the Effectiveness of Myofascial Release Techniques Applied to the Popliteus Muscle in Individuals With Knee Pain.

An interventional study of Myofascial Release in Knee Pain Chronic, sponsored by Istanbul Rumeli University. Completed at 1 site in Turkey (Türkiye). Open to participants aged 18 Years to 70 Years. Per ClinicalTrials.gov, last updated 2026-03-17.

Sponsored by Istanbul Rumeli University · Not applicable, Interventional, and Health services research

From the registry’s dates

  • Registered 3 months after the study started (first participant enrolled Oct 2025, registered Jan 2026).
Phase
Not applicable
Study type
Interventional
Enrollment
45
Allocation
Randomized
Ages
18 Years to 70 Years
Sex
All
01

Study summary

This study aimed to evaluate the effectiveness of popliteus muscle-targeted myofascial release techniques (MFR) when added to conventional physical therapy and rehabilitation (PTR) and exercise protocols in patients with knee pain.

Read the detailed description

This study aimed to evaluate the effectiveness of popliteus muscle-targeted myofascial release techniques (MFR) when added to conventional physical therapy and rehabilitation (PTR) and exercise protocols in patients with knee pain. Sixty patients presenting with knee pain were assessed according to inclusion and exclusion criteria, and 45 eligible participants were enrolled. Participants were allocated into two groups: the popliteus group (23) and the control group (22). Assessments were performed before treatment and after treatment. Both groups received a standard PTR program consisting of heat therapy (20 min), transcutaneous electrical nerve stimulation (TENS) (20 min), therapeutic ultrasound (US) (4 min), and exercises, administered 5 days per week for a total of 10 sessions. In addition, popliteus muscle-targeted MFR techniques were applied to the popliteus group. Outcome measures included pain (visual analog scale, VAS), functional status (Western Ontario and McMaster Universities Osteoarthritis Index, WOMAC), quality of life (Short Form-12 Health Survey, SF-12), range of motion (ROM), limb circumference measurement, and balance tests (single-leg stance test, SLST).

02

Conditions studied

  • Knee Pain Chronic

Keywords

  • Knee pain; Popliteus; Myofascial release; Manual therapy; Physical therapy and rehabilitation; WOMAC
03

In context

Lead sponsor

Istanbul Rumeli University is the lead sponsor of 26 studies on the registry; 11 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 70 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Being between 18-70 years of age
  • Being able to communicate in Turkish
  • Being literate
  • Having a diagnosis of non-specific knee pain, Patellafemoral pain syndrome, or Knee Osteoarthritis
  • Volunteering to participate in the study

Exclusion criteria

Exclusion Criteria:

  • Having undergone surgery on the knee joint
  • Having a diagnosis of inflammatory rheumatism
  • Having a significant clinical infection
  • Having a fracture in the bones forming the knee joint
  • Having received cortisol treatment within the last 6 months
  • Having a disease that prevents the patient from lying prone
  • Having a history of deep vein thrombosis
  • Having severe varicose vein disease
  • Being an active cancer patient
05

Study design

Phase
Not applicable
Primary purpose
Health services research
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Participant)
Enrollment
45 participants (actual)

Study arms

  • Active comparator
    Popliteus

    Myofascial Release Techniques Applied to the Popliteus Muscle

    Other: Myofascial Release

  • No intervention
    Kontrol Grubu

    Myofascial Release uygulanmadı

Interventions

  • OtherMyofascial Release

    Classical Myofascial Release

06

What researchers measure

Primary outcomes

  1. Myofascial Release Techniques AppliMeasurement of quality of life in individuals with knee pain following myofascial release techniques applied to the popliteus muscle.

    Measurement of quality of life in individuals with knee pain following myofascial release techniques applied to the popliteus muscle. The SF-12 scale was used as the measurement. Patella circumference measurements were also taken.

    Time frame: 5 days 10 sessions

07

Study locations

1 site
  • İstanbul Fatih Sultan Mehmet Eğitim ve Araştırma Hastahanesi
    Istanbul, Turkey (Türkiye)
08

References and documents

Publications

  • Flandry F, Hommel G. Normal anatomy and biomechanics of the knee. Sports Med Arthrosc Rev. 2011 Jun;19(2):82-92. doi: 10.1097/JSA.0b013e318210c0aa. PubMed 21540705 ↗

Individual participant data

Plan to share: Yes

Supporting information: Sap

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Mar 17, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT07474597
Lead sponsor
Istanbul Rumeli University
Responsible party
Aysegul Kutsal (physiotherapist, Istanbul Rumeli University) — Principal investigator
First posted
Mar 16, 2026
Start date
Oct 1, 2025
Primary completion
Jan 2, 2026
Completion
Jan 2, 2026
Last update
Mar 17, 2026

Study contacts

Ali CIMBIZ
study director · Istanbul Rumeli Universitesi

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Mar 2026. You cannot join it, but the record below documents what was studied.

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