An interventional study of Control and Intervention in Exercise Recovery, sponsored by University of Bath. Recruiting at 1 site in United Kingdom. Open to participants aged 18 Years to 45 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-03-16.
Sponsored by University of Bath · Not applicable, Interventional, and Basic science
Eccentric exercise, particularly when novel and strenuous, can cause soreness and inflammation, impairing subsequent exercise performance. These performance decrements are attributable to oxidative stress and inflammation. Interestingly, a single bout of eccentric exercise can confer protective effects, ameliorating the negative consequences in subsequent bouts. This is termed the repeated bout effect (RBE), which would be of interest to athletes considering the detrimental effects of strenuous eccentric exercise. Athletes regularly consume supplements in hope of attenuating the performance decrements after strenuous eccentric exercise
. However, considering the dose-response relationship between the initial performance decrement and the magnitude of the RBE , supplements may diminish the obtainment of the RBE. This notion remains untested, and so the proposed project is a double-blind, placebo-controlled, parallel group study aiming to assess the effects of acute vitamin C and ibuprofen supplementation on the development of the RBE. These two supplements were chosen as they are most frequently and successfully used in the literature to target oxidative stress (vitamin C) and inflammation (ibuprofen). Additionally, these doses (and the timing of supplements) were chosen to mimic protocols reporting beneficial effects
University of Bath is the lead sponsor of 94 studies on the registry; 20 are open to participants now.
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Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Vitamin C and Non-steroidal anti-inflammatory drug
Dietary Supplement: Intervention
Identical Placebo
Dietary Supplement: Control
Identical maltodextrin tablet. Appearance and weight matched
1,000 mg Vitamin C and 400 mg non-steroidal anti-inflammatory drug every 8-h for 48-h
Muscle Function
Jump height calculated through flight time
Time frame: Baseline and post exercise (2 hours, 1 day, 7 day)
Muscle Function
Peak power quantified using a Keiser Leg Press
Time frame: Baseline and post exercise (2 hours, 1 day, 7 day)
Muscle Function
Peak force quantified using a Keiser Leg Press
Time frame: Baseline and post exercise (2 hours, 1 day, 7 day)
Muscle Function
Peak velocity quantified using a Keiser Leg Press
Time frame: Baseline and post exercise (2 hours, 1 day, 7 day)
Creatine Kinase
Plasma Creatine Kinase
Time frame: Baseline and immediately, 1-h (hour)-, 2-h-, 24-h-,and 48-hours-post-exercise
Plan to share: Yes
No publications or documents are linked to this record.
Started Sep 2025 (actual). Primary completion is estimated for Feb 2027, 17 months after the start.
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University of Bath