ClinicalTrials.gg
Not yet recruitingNCT07468266Updated Mar 12, 2026

Nasal Airflow in Post-operative Patients

An interventional study of TUI-1 and TUI-2 in Invasive Ventilation, sponsored by Fisher and Paykel Healthcare. Not yet recruiting at 1 site in New Zealand. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-03-12.

Sponsored by Fisher and Paykel Healthcare · Not applicable, Interventional, and Other

Phase
Not applicable
Study type
Interventional
Enrollment
12
Allocation
Randomized
Ages
18 Years and older
Sex
All
01

Study summary

The goal of this investigation is to examine the effect of nasal airflow in invasively ventilated adult patients following planned surgery. The main questions it aims to answer are:

  • Does the investigational device produce an effect measured by EEG?
  • Are there differences in effect with modified airflow states?
02

Conditions studied

  • Invasive Ventilation
03

In context

Lead sponsor

Fisher and Paykel Healthcare is the lead sponsor of 86 studies on the registry; 16 are open to participants now.

Of its 11 completed or terminated interventional studies of FDA-regulated products, 10 (91%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Adults >18 years of age
  • Receiving sedation via propofol and fentanyl
  • Undergoing surgical procedure with planned post-operative invasive ventilation

Exclusion criteria

Exclusion Criteria:

  • Pre-existing neurological injury or condition
05

Study design

Phase
Not applicable
Primary purpose
Other
Allocation
Randomized
Intervention model
Crossover assignment
Masking
None (open label)
Enrollment
12 participants (estimated)

Study arms

  • Active comparator
    TUI-A

    Receipt of TUI-1 followed by TUI-2

    Device: TUI-1 · Device: TUI-2

  • Active comparator
    TUI-B

    Receipt of TUI-2 followed by TUI-1

    Device: TUI-1 · Device: TUI-2

Interventions

  • DeviceTUI-1

    Provision of airflow to the nasal cavity by F\&P Tui at baseline rate

  • DeviceTUI-2

    Provision of airflow to the nasal cavity by F\&P Tui at modified rate

06

What researchers measure

Primary outcomes

  1. Power spectral density of EEG

    Mean PSD will be calculated across beta, alpha, delta and gamma frequency bands

    Time frame: Before and 10 minutes after initiation of nasal airflow

Secondary outcomes

  1. Power spectral density of EEG between interventions

    Mean PSD will be calculated across beta, alpha, delta and gamma frequency bands and compared between TUI-1 and TUI-2

    Time frame: 10 minutes after initiation of nasal airflow

  2. Coherence

    Inter-regional EEG coherence will be quantified as a measure of functional connectivity

    Time frame: Before and 10 minutes after initiation of nasal airflow

07

Study locations

1 site
  • Department of Critical Care Medicine, Auckland City Hospital
    Auckland, New Zealand
    • Christopher Hands · Principal investigator
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Mar 12, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT07468266
Responsible party
Sponsor
First posted
Mar 12, 2026
Start date
Mar 2026 (estimated)
Primary completion
Feb 2027 (estimated)
Completion
Feb 2027 (estimated)
Last update
Mar 12, 2026

Study contacts

Kelly Gradon
Contact
kelly.gradon@fphcare.co.nz
09 574 0100

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is not yet recruiting, as verified in Mar 2026. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion