An interventional study of AG1 - Nutritional Supplement and Placebo in Nutrition Intake, Nutrition Status and Gastrointestinal Microbiome, sponsored by Athletic Greens International. Recruiting at 1 site in United States. Open to participants aged 18 Years to 59 Years. Per ClinicalTrials.gov, last updated 2026-02-27.
Sponsored by Athletic Greens International · Not applicable, Interventional, and Supportive care
This study is a triple-blind, placebo-controlled, randomized controlled trial of 120 adults that will evaluate the impact of a novel nutritional supplement on improving nutrient gaps and changing nutrient status and the gut microbiome among glucagon-like peptide-1 receptor agonist (GLP-1 RA) users.
Athletic Greens International is the lead sponsor of 8 studies on the registry; 3 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
AG1 - Nutritional Supplement
Dietary Supplement: AG1 - Nutritional Supplement
Dietary Supplement: Placebo
AG1 - Nutritional Supplement
Maltodextrin Placebo
Nutrient Gaps
Assess nutrient gaps by dietary record assessment utilizing The Automated Self-Administered 24-hour (ASA24®) Dietary Assessment Tool
Time frame: 90 days
Nutrient Status Markers
Circulating concentrations of nutrient status (homocysteine, folate, Vitamin A, Vitamin C, Vitamin D, Vitamin E, Thiamin, Riboflavin, Niacin, Vitamin B6, Vitamin B12, Zinc)
Time frame: 90 days
Gut Microbiome
Examine changes in the gut microbiome via fecal metagenomics
Time frame: 90 days
GI Symptoms
The Gastrointestinal Symptom Rating Scale will be provided to assess the effect of the intervention on GI symptoms. Scores range from 1 to 7 with a higher score indicating a higher level of discomfort
Time frame: 90 days
Digestive Quality of Life
A Digestive Quality of Life Questionnaire (DQLQ) will be utilized to assess the effect of the interventions on participant's digestive health. Scores range from 0 to 9 with a higher score indicating worse digestion associated with quality of life
Time frame: 90 days
Functional Impairment
The Sheehan Disability Scale will be utilized to assess functional impairment.
Time frame: 90 days
Ingestive Behavior
Food cravings will be measured using the General Food Cravings Questionnaire.
Time frame: 90 days
Energy
The Fatigue Assessment Scale will be utilized to assess the impact of the intervention on symptoms of fatigue.
Time frame: 90 days
Serum concentrations of sodium
Measured using a Comprehensive Metabolic Panel
Time frame: 90 days
Serum concentrations of Potassium
Measured in a Comprehensive Metabolic Panel
Time frame: 90 days
Serum concentrations of carbon dioxide
Measured in a Comprehensive Metabolic Panel
Time frame: 90 days
Serum concentrations of chloride
Measured in a Comprehensive Metabolic Panel
Time frame: 90 days
Serum concentrations of albumin
Measured in a Comprehensive Metabolic Panel
Time frame: 90 days
Serum concentrations of total protein
Measured in a Comprehensive Metabolic Panel
Time frame: 90 days
Serum concentrations of glucose
Measured in a Comprehensive Metabolic Panel
Time frame: 90 days
Serum concentrations of calcium
Measured in a Comprehensive Metabolic Panel
Time frame: 90 days
Serum concentrations of ALT
Measured in a Comprehensive Metabolic Panel
Time frame: 90 days
Serum concentrations of AST
Measured in a Comprehensive Metabolic Panel
Time frame: 90 days
Serum concentrations of bilirubin
Measured in a Comprehensive Metabolic Panel
Time frame: 90 days
Serum concentrations of Blood Urea Nitrogen
Measured in a Comprehensive Metabolic Panel
Time frame: 90 days
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
Contact study teamGet an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Athletic Greens International