An interventional study of high power laser therapy and Basic oral care in Oral Mucositis, sponsored by Ain Shams University. Recruiting at 1 site in Egypt. Open to participants aged Up to 18 Years. Per ClinicalTrials.gov, last updated 2026-03-19.
Sponsored by Ain Shams University · Not applicable, Interventional, and Treatment
The goal of this clinical trial is to learn if high-level laser therapy can manage oral mucositis in pediatric patients undergoing hematopoietic bone marrow transplantation. The main question it aims to answer is :
Is high-level laser therapy effective as a treatment for oral mucositis in pediatric hemopoietic stem cell transplant patients? Researchers will compare patients receiving basic oral care to see the effect on the WHO oral mucositis scale.
Participants will be subjected to high level laser on lesion sites .
306 studies on the registry are indexed under Stomatitis; 75 are open to participants now.
This study's planned enrollment of 14 is below the median of 60 across 276 interventional studies indexed under Stomatitis.
Browse Stomatitis studies →Ain Shams University is the lead sponsor of 1,950 studies on the registry; 429 are open to participants now.
Of its 35 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
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Exclusion Criteria:
Pediatric bone marrow transplantation patients with oral mucositis will receive high-power laser therapy once daily for four consecutive days. The laser parameters will be a wavelength of 660 to 970 nm, of power 3.2 w, pulsed at 50% duty cycle, spot size of 1 cm2, for 230 sec, defocused mode.
Device: high power laser therapy
Pediatric bone marrow transplantation patients with oral mucositis will receive standard basic oral care. Local methods: mouth rinse chlorohexidine three times a day, sodium bicarbonate mouthwash.
Drug: Basic oral care
high power laser therapy once daily for four consecutive days with wavelength 660 to 970 nm, power 3.2 w, and duration of 230 seconds at 50% duty cycle
Also known as: Laser biostimulation, Photobiomodulation therapy
patients will receive local methods: cholorohexidine mouthwash as well sodium bicarbonate mouthwash
Also known as: conventional therapy
Oral mucositis score
World Health Organization (WHO) scale of oral mucositis will be used to describe the lesions at baseline, day 7 and day 11, lesions are given grades from 1 to 4, with 4 being a worse outcome
Time frame: at baseline (day 1), day 7, and day 11 from the start of treatment
Pain score
Pain visual analogue scale will be used to measure pain level, where the patient will be given a diagram representing pain levels from 1 to 10, 10 being the highest level of pain
Time frame: at baseline (day 1), day 7, and day 11 from the start of treatment
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