An interventional study of Exporlation Tympanotomy in Conductive Hearing Loss, Unilateral, sponsored by Al-Azhar University. Recruiting at 1 site in Egypt. Per ClinicalTrials.gov, last updated 2026-07-24.
Sponsored by Al-Azhar University · Not applicable, Interventional, and Treatment
Unilateral conductive hearing loss (UCHL) in the presence of an intact tympanic membrane represents a diagnostic challenge in otologic practice. In the absence of middle ear effusion or tympanic membrane pathology, stapes fixation secondary to otosclerosis is often considered the most probable diagnosis. However, although otosclerosis is traditionally regarded as a bilateral disease, clinical presentation may be unilateral due to asymmetric disease progression or subclinical contralateral involvement. Other etiologies, including congenital ossicular anomalies, ossicular discontinuity, tympanosclerosis without tympanic membrane involvement, or oval window abnormalities, may mimic otosclerosis both clinically and audiologically. Consequently, exploratory tympanotomy remains the gold standard for definitive diagnosis, allowing direct assessment of ossicular chain mobility and confirmation of stapes fixation. Correlating preoperative clinical suspicion with intraoperative findings is therefore essential to better define the true causes of unilateral conductive hearing loss with an intact tympanic membrane.
82 studies on the registry are indexed under Hearing Loss, Conductive; 15 are open to participants now.
This study's planned enrollment of 100 is above the median of 30 across 59 interventional studies indexed under Hearing Loss, Conductive.
Browse Hearing Loss, Conductive studies →Al-Azhar University is the lead sponsor of 531 studies on the registry; 172 are open to participants now.
Of its 5 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
Counted across the registry records on this site, refreshed daily.
Inclusion Criteria:
Patients who presented with unilateral conductive hearing loss with intact tympanic membrane will undergo exploration tympanoplasty to diagnose underlying causes and correct them surgically if possible
Procedure: Exporlation Tympanotomy
exploration tympanotomy of the middle ear and ossicles to diagnose or detect actual causes of conductive hearing loss and correct it according to the cause
Improvement of the Airborne ( conductive ) gap
Difference between preoperative and postoperative Average Airbone gap in dicebel
Time frame: up to three months Surgery
Plan to share: No — Individual participant data will not be shared due to institutional ethical restrictions and the retrospective nature of the study. The dataset contains potentially identifiable clinical and surgical information. De-identified aggregated data may be made available upon reasonable request to the corresponding author, subject to institutional review and approval.
No publications or documents are linked to this record.
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
Contact study teamGet an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.