An interventional study of Exporlation Tympanotomy in Conductive Hearing Loss, Unilateral, sponsored by Al-Azhar University. Recruiting at 1 site in Egypt. Per ClinicalTrials.gov, last updated 2026-07-24.
Sponsored by Al-Azhar University · Not applicable, Interventional, and Treatment
Unilateral conductive hearing loss (UCHL) in the presence of an intact tympanic membrane represents a diagnostic challenge in otologic practice. In the absence of middle ear effusion or tympanic membrane pathology, stapes fixation secondary to otosclerosis is often considered the most probable diagnosis. However, although otosclerosis is traditionally regarded as a bilateral disease, clinical presentation may be unilateral due to asymmetric disease progression or subclinical contralateral involvement. Other etiologies, including congenital ossicular anomalies, ossicular discontinuity, tympanosclerosis without tympanic membrane involvement, or oval window abnormalities, may mimic otosclerosis both clinically and audiologically. Consequently, exploratory tympanotomy remains the gold standard for definitive diagnosis, allowing direct assessment of ossicular chain mobility and confirmation of stapes fixation. Correlating preoperative clinical suspicion with intraoperative findings is therefore essential to better define the true causes of unilateral conductive hearing loss with an intact tympanic membrane.
Inclusion Criteria:
Patients who presented with unilateral conductive hearing loss with intact tympanic membrane will undergo exploration tympanoplasty to diagnose underlying causes and correct them surgically if possible
Procedure: Exporlation Tympanotomy
exploration tympanotomy of the middle ear and ossicles to diagnose or detect actual causes of conductive hearing loss and correct it according to the cause
Improvement of the Airborne ( conductive ) gap
Difference between preoperative and postoperative Average Airbone gap in dicebel
Time frame: up to three months Surgery
Plan to share: No — Individual participant data will not be shared due to institutional ethical restrictions and the retrospective nature of the study. The dataset contains potentially identifiable clinical and surgical information. De-identified aggregated data may be made available upon reasonable request to the corresponding author, subject to institutional review and approval.
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Al-Azhar University