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CompletedNCT07425288Updated Feb 20, 2026

Contralateral Effects of Unilateral Isokinetic vs. Single-Leg Squat Training in Sedentary Women

An interventional study of Unilateral Isokinetic Training and Unilateral Single-Leg Squat Training in Muscle Strength and Proprioception, sponsored by Cagatay Muslum Gokdogan. Completed at 1 site in Turkey (Türkiye). Open to female participants aged 18 Years to 35 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-02-20.

Sponsored by Cagatay Muslum Gokdogan · Not applicable, Interventional, and Other

From the registry’s dates

  • Registered 2 years 2 months after the study started (first participant enrolled Nov 2023, registered Feb 2026).
Phase
Not applicable
Study type
Interventional
Enrollment
47
Allocation
Randomized
Ages
18 Years to 35 Years
Sex
Female
01

Study summary

This randomized controlled trial aims to investigate the contralateral effects of unilateral training in sedentary women. Specifically, the study compares unilateral isokinetic training and single-leg squat training to determine their effects on strength, proprioception, and muscle thickness in both the trained and untrained lower extremities.

Participants will be randomly assigned to one of the training groups. The intervention will be applied to one lower limb only. Strength, proprioception, and muscle thickness will be assessed before and after the intervention period. The primary objective is to evaluate whether unilateral training induces cross-education effects in the contralateral limb.

The findings of this study may contribute to rehabilitation strategies by clarifying the potential benefits of unilateral exercise programs for improving neuromuscular performance and muscle morphology in sedentary individuals.

02

Conditions studied

  • Muscle Strength
  • Proprioception

Keywords

  • contralateral training
  • isokinetic training
  • single-leg squat
  • proprioception.
03

In context

Lead sponsor

This is the only study on the registry with Cagatay Muslum Gokdogan as lead sponsor.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 35 Years
Sexes eligible
Female
Accepts healthy volunteers
Yes

Inclusion criteria

  • female gender,
  • no lower extremity problems in the last 6 months,
  • not actively participating in sports

Exclusion criteria

Exclusion Criteria:

  • history of orthopedic surgery within the last 2 years,
  • ongoing lower extremity pain, systemic disease that could prevent exercise,
  • a neurological problems.
05

Study design

Phase
Not applicable
Primary purpose
Other
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Outcomes assessor)
Enrollment
47 participants (actual)

Study arms

  • Experimental
    Unilateral Isokinetic Training

    Participants in this group will receive unilateral isokinetic strength training applied to one lower extremity only. The contralateral limb will not receive any direct intervention.

    Behavioral: Unilateral Isokinetic Training

  • Experimental
    Unilateral Single-Leg Squat Training

    Participants in this group will perform unilateral single-leg squat training on one lower extremity only. The opposite limb will not receive any direct training.

    Behavioral: Unilateral Single-Leg Squat Training

  • No intervention
    Control Group

    Participants in this group will not receive any exercise or training intervention during the study period and will continue their usual daily activities.

Interventions

  • BehavioralUnilateral Isokinetic Training

    Unilateral isokinetic strength training will be applied to one lower extremity using an isokinetic dynamometer. The training program will be performed according to the study protocol. The contralateral limb will not receive any direct intervention.

  • BehavioralUnilateral Single-Leg Squat Training

    Participants will perform unilateral single-leg squat exercises on one lower extremity according to the study protocol. The opposite limb will not receive any direct training.

06

What researchers measure

Primary outcomes

  1. Muscle Strength

    Muscle strength of the lower extremities will be assessed using isokinetic dynamometry to evaluate peak torque values in both the trained and contralateral limbs.

    Time frame: Baseline and after 6 weeks of intervention

Secondary outcomes

  1. Proprioception

    Lower extremity proprioception will be evaluated using joint position sense assessment to determine proprioceptive accuracy in both limbs.

    Time frame: Baseline and after 6 weeks of intervention

  2. Muscle Thickness

    Muscle thickness of selected thigh muscles will be measured using ultrasonography to assess morphological adaptations following unilateral training.

    Time frame: Baseline and after 6 weeks of intervention

07

Study locations

1 site
  • Gazi University, Faculty of Health Sciences
    Ankara, Ankara 06560, Turkey (Türkiye)
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Feb 20, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT07425288
Lead sponsor
Cagatay Muslum Gokdogan
Responsible party
Cagatay Muslum Gokdogan (Research Assistant, Harran University) — Sponsor-investigator
First posted
Feb 20, 2026
Start date
Nov 15, 2023
Primary completion
Apr 10, 2024
Completion
May 22, 2024
Last update
Feb 20, 2026

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Feb 2026. You cannot join it, but the record below documents what was studied.

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