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CompletedNCT07419074Updated Feb 18, 2026

Hypoglycemic Potential of Garcinia Cambogia (Garcinia Gummi-gutta (L.) N.Robson) Rind Powder Among Pre-diebetic Obese Patients

An interventional study of Garcinia cambogia rind powder and Garcinia cambogia rind powder in Lipid Profile, sponsored by University of Lahore. Completed at 1 site in Pakistan. Open to participants aged 30 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-02-18.

Sponsored by University of Lahore · Not applicable, Interventional, and Health services research

From the registry’s dates

  • Registered 5 months after the study started (first participant enrolled Sep 2025, registered Feb 2026).
Phase
Not applicable
Study type
Interventional
Enrollment
90
Allocation
Randomized
Ages
30 Years to 60 Years
Sex
All
01

Study summary

Garcinia cambogia, rich in hydroxycitric acid (HCA), has been suggested to promote weight loss and improve metabolic parameters. Evidence regarding its efficacy in pre-diabetic obese adults remains limited.

Objective: To evaluate the effects of Garcinia cambogia rind powder supplementation on anthropometric, glycemic, lipid, hepatic, and renal parameters in pre-diabetic obese adults.

Read the detailed description

The observed effects are likely mediated by HCA, which inhibits ATP-citrate lyase, reducing de novo lipogenesis, enhancing glucose utilization, and modulating adipokines and oxidative stress.

Conclusion: Garcinia cambogia rind powder supplementation exerts dose-dependent metabolic benefits in pre-diabetic obese adults, improving anthropometric, glycemic, lipid, hepatic, and renal parameters without adverse effects. It may serve as a complementary intervention alongside lifestyle modification for the management of obesity and pre-diabetes.

02

Conditions studied

  • Lipid Profile

Keywords

  • Garcinia cambogia, Garcinia gummi-gutta, hypoglycemic effect, pre-diabetic, obesity, hydroxycitric acid (HCA), glucose metabolism
03

In context

Glucose Intolerance

778 studies on the registry are indexed under Glucose Intolerance; 129 are open to participants now.

This study's enrollment of 90 is above the median of 60 across 645 interventional studies indexed under Glucose Intolerance.

Browse Glucose Intolerance studies →

Lead sponsor

University of Lahore is the lead sponsor of 223 studies on the registry; 40 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
30 Years to 60 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • Participants of both genders were included if they were aged 30-60 years,
  • body mass index (BMI) ≥30 kg/m²,
  • Individuals with HbA1c levels ranging from 5.7% to 10% were selected, .indicating pre-diabetic to diabetic status. Participants were required to have a .body mass index (BMI) of 25 kg/m² or higher

Exclusion criteria

Exclusion Criteria:

  • Participants who were diagnosed with type 1, pregnant or lactating,
  • chronic liver, kidney, or cardiovascular disease,
  • history of hepatotoxicity or gastrointestinal disorders,
  • using weight-loss supplements, steroids, or lipid-lowering drugs, or had a known allergy to Garcinia cambogia
05

Study design

Phase
Not applicable
Primary purpose
Health services research
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
90 participants (actual)

Study arms

  • Placebo comparator
    Placebo group

    Starch capsule once a day

    Dietary Supplement: Garcinia cambogia rind powder

  • Experimental
    T1

    100mg/day of Garcinia cambogia rind powder

    Dietary Supplement: Garcinia cambogia rind powder

  • Experimental
    T2

    200mg/day of Garcinia cambogia rind powder

    Dietary Supplement: Garcinia cambogia rind powder

Interventions

  • Dietary supplementGarcinia cambogia rind powder

    Once a day

  • Dietary supplementGarcinia cambogia rind powder

    Once a day for 12 weeks

06

What researchers measure

Primary outcomes

  1. Weight

    Time frame: 12 weeks

Secondary outcomes

  1. Lipid profile

    Time frame: 12 weeks

  2. fasting glucose

    Time frame: 12 weeks

07

Study locations

1 site
  • Sana Noreen
    Lahore, 54000, Pakistan
08

References and documents

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Feb 18, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT07419074
Lead sponsor
University of Lahore
Responsible party
Sponsor
First posted
Feb 18, 2026
Start date
Sep 1, 2025
Primary completion
Nov 24, 2025
Completion
Jan 1, 2026
Last update
Feb 18, 2026

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Oct 2025. You cannot join it, but the record below documents what was studied.

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