CClinicalTrials.gg
RecruitingNCT07415109Updated Apr 13, 2026

Improving LDL-C Levels Through Temporal Self-regulation Theory-based, Personality-tailored Health Messages

An interventional study of General Message and Personalized Message in Adherence and Preventive Health Services, sponsored by National University Health System, Singapore. Recruiting at 1 site in Singapore. Open to participants aged 21 Years to 65 Years. Per ClinicalTrials.gov, last updated 2026-04-13.

Sponsored by National University Health System, Singapore · Not applicable, Interventional, and Prevention

From the registry’s dates

  • Started Nov 2025; still recruiting 10 months later.
Phase
Not applicable
Study type
Interventional
Enrollment
3,000
Allocation
Randomized
Ages
21 Years to 65 Years
Sex
All
01

Study summary

The study is meant to run parallel to the larger study, RESET. The goal of this study is to to evaluate the effectiveness of a once-off general and personality-tailored text message on GP consultation among RESET participants identified to have high LDL-C. The main question it aims to answer is:

Will participants exposed to personality tailored advice have a higher adherence to GP consultation compared to the participants in the control group?

Researchers will compare a personalized message to a general message (with no personalization according to patients personality type) and control group to see if the messages increase adherence.

Participants are required to complete two questionnaires: one before and one after they receive their RESET results.

02

Conditions studied

  • Adherence
  • Preventive Health Services
03

In context

Lead sponsor

National University Health System, Singapore is the lead sponsor of 40 studies on the registry; 12 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
21 Years to 65 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • New participants of RESET who have given consent to be contacted for future studies
  • ≥21 years old

Exclusion criteria

Exclusion Criteria:

  • are not able to read, write or communicate in English
05

Study design

Phase
Not applicable
Primary purpose
Prevention
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
3,000 participants (estimated)

Study arms

  • Experimental
    Personality-Tailored Message

    Behavioral: Personalized Message

  • Active comparator
    General Message

    Behavioral: General Message

  • No intervention
    Control

Interventions

  • BehavioralGeneral Message

    The intervention will consist of messages and infographics embedded in participants' return of results (ROR) emails within the RESET study. Each participant will receive the ROR alongside the intervention once, at the time their results are sent. No repeat messages will be delivered. The general health message will include indications for lipid therapy, benefits of lipid-lowering medications, common side effects, risks of non-adherence, and an infographic on diet and lifestyle modification based on ACE lipid management guidance. The infographic will be included in the same ROR email.

  • BehavioralPersonalized Message

    The intervention will consist of messages and infographics embedded in participants' return of results (ROR) emails within the RESET study. Each participant will receive the ROR alongside the intervention once, at the time their results are sent. No repeat messages will be delivered. The message will include the personality-tailored message with the same core content as the general message, including indications for lipid therapy, benefits of lipid-lowering medications, common side effects, risks of non-adherence, and an infographic on diet and lifestyle modification based on ACE lipid management guidance. An infographic will be included in the same ROR email. This message will contain an added component framed according to conscientiousness and neuroticism scores, as these traits are strong predictors of health behaviours. Scores will be derived from baseline BFI-44 results.

06

What researchers measure

Primary outcomes

  1. Intention to adopt a healthier diet

    A 3-item, 7-point Likert scale assessing participants' intention to adopt a healthier diet. The minimum and maximum score one can attain on this measure is 3 and 21 respectively, with a higher score indicating higher intention to adopt a healthier diet.

    Time frame: From enrollment to 3 months after results have been returned.

  2. Intention to engage in Physical Activity

    A 3-item, 7-point Likert scale assessing participants' intention to engage in physical activity. The minimum and maximum score one can attain on this measure is 3 and 21 respectively, with a higher score indicating higher intention to engage in physical activity.

    Time frame: From enrollment to 3 months after results have been returned.

  3. Intention to visit a General Practitioner

    A 3-item, 7-point Likert scale assessing participants' intention to visit a general practitioner. The minimum and maximum score one can attain on this measure is 3 and 21 respectively, with a higher score indicating higher intention to visit a general practitioner.

    Time frame: 3 months after results have been returned.

Other outcomes

  1. Big Five Inventory - 44

    A 44-item, 5-point Likert scale questionnaire that assesses the "Big Five" personality traits of a participant: namely Openness, Conscientiousness, Extraversion, Agreeableness, and Neuroticism, each represented as sub-scales. Subscale scores are calculated by summing the relevant items. The minimum / maximum score for each sub-scale is as follows, with higher scores indicating higher representation of the respective personality trait. Openness: 10/50 Conscientiousness: 9/45 Extraversion: 8/40 Agreeableness: 9/45 Neuroticism: 8/40

    Time frame: From enrollment

07

Study locations

1 of 1 sites recruiting
  • National University of Singapore
    Singapore, 117599, Singapore
    Recruiting
08

References and documents

Individual participant data

Plan to share: Undecided

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Apr 13, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT07415109
Lead sponsor
National University Health System, Singapore
Responsible party
Jocelyn Chew (Assistant Professor, National University Health System, Singapore) — Principal investigator
First posted
Feb 17, 2026
Start date
Nov 25, 2025
Primary completion
Jan 2028 (estimated)
Completion
Nov 2028 (estimated)
Last update
Apr 13, 2026

Study contacts

Jocelyn Chew
Contact
dbi-lab@nus.edu.sg
+6565168687

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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