An interventional study of Program (Systematic Minimal Early Intervention for Eating Disorders) in Eating Disorders, sponsored by Centre Hospitalier St Anne. Recruiting at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-02-17.
Sponsored by Centre Hospitalier St Anne · Not applicable, Interventional, and Prevention
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Among 49 studies in Feeding and Eating Disorders with a site in France — 11 open to participants now, 14 under way, none of them phase 3. Feeding and Eating Disorders · France.
Among the 49 studies in Feeding and Eating Disorders with a site in France, this one is the 4th largest by planned enrollment of the 20 interventional ones that give a count, is one of 8 that started in 2025, is one of 17 with no phase, reaches primary completion later than 10 of the 13 other live ones, and was the 47th registered.
645 studies on the registry are indexed under Feeding and Eating Disorders; 153 are open to participants now.
Browse Feeding and Eating Disorders studies →11 of the 49 studies in Feeding and Eating Disorders with a site in France are open now. Recruiting first, the newest first:
Universite du Littoral Cote d'Opale · Sites in France
Ages 18+
Centre Hospitalier Esquirol · Sites in France
Ages 18–65
University Hospital, Strasbourg, France · Sites in France
Ages 18+
Centre Hospitalier Universitaire de Besancon · Sites in France
Ages 18–60 · Women only · Healthy volunteers
University Hospital, Grenoble · Sites in France
Ages 18+
A study can be open while its sites in France have not opened yet or have stopped. Only those recruiting at a site in France →
Of the 100 Feeding and Eating Disorders studies recruiting now, 31 (31%) set no upper age limit and 67 (67%) stop at 75 or younger; 45 take children under 18; 20 take healthy volunteers.
This study: 18 Years and older · all sexes · no healthy volunteers.
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49 studies; the count open now beside each. This study's row is marked.
First in 2004; this study’s year is marked. 8 started in 2025.
By drug class, each counting the studies that test any of its medicines:
This study's planned enrollment of 215 is above the median of 71 across 452 interventional studies indexed under Feeding and Eating Disorders.
Median enrollment 76 across the 20 interventional studies, 100 across the 29 observational. Of the 29 that completed or were terminated, 0 (0%) have results posted.
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2 of 49 have an industry lead sponsor. The 10 most frequent:
Centre Hospitalier St Anne is the lead sponsor of 101 studies on the registry; 55 are open to participants now.
Centre Hospitalier St Anne has 2 studies filed under Feeding and Eating Disorders — fewer than ten, so there is no comparison to draw.
3 of the studies in Feeding and Eating Disorders with a site in France that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT05770089University Hospital, CaenVideoconferencing Adapted Physical Activity in Anorexia Nervosa: a Pilot Study | 2026-12-01 |
| NCT07151924University Hospital, ToulouseEating Disturbances in Patients With Type 1 Diabetes Initiating Insulin Therapy | 2027-02-28 |
| NCT07411807Centre Hospitalier St AnneStudy of the Effectiveness of a Systematic Minimal Early Intervention on Care Engagement in Adults With Eating Disorders Requesting Specialized Treatment. | 2027-04 |
Add all 3 to your calendar (.ics) → With an account.
Among the 49 studies in Feeding and Eating Disorders with a site in France, from their registry updates:
This tab as a report to print or save as PDF → With an account.
Eating disorders (EDs) are complex psychiatric conditions-such as anorexia nervosa and bulimia nervosa-often emerging in young adulthood and associated with high morbidity and mortality. Despite their severity, access to specialized care remains difficult, delayed by shame, stigma, and a lack of insight among patients, as well as long waiting times and limited specialized resources.
The AGIS-TCA pilot study aims to evaluate the effectiveness of a systematic minimal early intervention designed to reduce the number of patients lost to follow-up between their request for specialized care and the actual start of treatment.
This monocentric, low-risk interventional study will be conducted at the Clinique des Maladies Mentales et de l'Encéphale (CMME), GHU Paris Psychiatrie \& Neurosciences. The intervention includes three early, structured telephone calls and five online support group sessions offered during the waiting period for care.
The main objective is to determine whether this proactive approach decreases attrition rates ("lost to follow-up") compared with a historical cohort. Secondary objectives include assessing the acceptability of early phone contact, adherence to support groups, and describing the clinical and sociodemographic profiles of patients requesting care or lost to follow-up.
The expected benefit is to facilitate timely access to care for vulnerable patients, prevent symptom worsening, and strengthen engagement in treatment pathways. Risks and constraints are minimal, as participation involves only remote interactions without any invasive procedures.
Eating disorders (EDs) such as anorexia nervosa and bulimia nervosa are severe psychiatric illnesses characterized by pathological eating behaviors and body-weight control strategies that significantly affect physical and mental health. These disorders typically emerge around age 18 and affect up to 2 million people in France. Despite the recognized importance of early treatment, many patients experience delays in accessing specialized care due to structural barriers (long waiting times, lack of resources) and individual factors (shame, denial, and poor insight into the illness).
At the Clinique des Maladies Mentales et de l'Encéphale (CMME), GHU Paris Psychiatrie \& Neurosciences, approximately 20-25% of patients who request specialized care for an eating disorder are lost to follow-up before starting treatment. These individuals often fail to complete their application or do not attend the initial evaluation. The AGIS-TCA (Action Globale d'Intervention Systématique - Troubles du Comportement Alimentaire) study addresses this critical period between the request for care and the beginning of treatment.
The study tests the effectiveness and acceptability of a minimal, systematic, early intervention that supports patients during this waiting phase. The intervention consists of:
Three structured telephone calls (AT1, AT2, AT3) conducted at approximately day 7, day 45, and day 90 after the validation of the care request. These calls aim to maintain contact, provide information, assess needs, and strengthen motivation.
Five online support and education group sessions, each lasting 60 minutes and held biweekly, led by a multidisciplinary team (specialized nurse, physician, dietitian, psychologist, psychomotor therapist, and peer support worker). Topics include medical aspects of EDs, body image, emotions, dietetics, and relationships with relatives.
This proactive "outreach" approach is compared to a historical control cohort from the previous year, managed under standard procedures (no systematic follow-up during the waiting period).
The primary endpoint is the rate of patients lost to follow-up (patients who requested care but did not attend evaluation or start treatment within 10 months).
Secondary endpoints include:
Participation rate in support groups.
Acceptance rate of early telephone contact.
Sociodemographic and clinical characterization of patients requesting care and those lost to follow-up.
The study is monocentric, non-randomized, and involves minimal risk. It includes 215 adult participants living in the Île-de-France region who have requested care for anorexia or bulimia at the CMME.
Expected benefits include improved engagement in care, reduced loss to follow-up, and earlier access to specialized treatment. The intervention is non-invasive, free of physical constraints, and participation or withdrawal has no impact on future access to care.
If effective and acceptable, the results of this pilot study could support the implementation of similar early intervention programs across other specialized eating disorder centers and form the basis for a multicenter study assessing long-term clinical outcomes and cost-effectiveness.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Poor understanding of the French language
Sensory impairment significantly affecting telephone communication
Patient currently receiving care at a specialized eating disorder facility at the time of the call
Patient not consenting to participate in the study
Subject under legal protection measures (guardianship or curatorship)
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Participants will receive a systematic minimal early intervention designed to maintain engagement during the waiting period before specialized treatment for an eating disorder. The intervention includes: Three structured telephone calls (AT1, AT2, AT3) at approximately day 7, day 45, and day 90 after validation of the care request. These calls aim to provide information, emotional support, and risk prevention guidance, and to maintain motivation for treatment. Five online support group sessions (60 minutes each, every two weeks) led by a multidisciplinary team (specialized nurse, physician, dietitian, psychologist, psychomotor therapist, and peer support worker). Duration: 3 months per participant. Number of Participants: 215 adults. Study Site: Clinique des Maladies Mentales et de l'Encéphale (CMME), GHU Paris Psychiatrie \& Neurosciences.
Other: Program (Systematic Minimal Early Intervention for Eating Disorders)
A historical cohort of patients who requested specialized care for an eating disorder during the previous year (01/11/2024-31/10/2025), before implementation of the AGIS-TCA program. These patients received standard care procedures, which involved no systematic contact during the waiting period between their request for treatment and the start of care.
The AGIS-TCA intervention consists of a structured early proactive support program designed to maintain patient engagement during the waiting period before specialized treatment for eating disorders
Rate of Patients Lost to Follow-Up
The primary outcome is the difference in the rate of patients lost to follow-up between the intervention group (AGIS-TCA program) and a historical control cohort. A patient is considered lost to follow-up if they have submitted a valid request for specialized care (excluding cases of reorientation) but have not attended the evaluation days at the Eating Disorders Expert Center (CMME) or completed their intake process within 10 months of their initial request.
Time frame: 7 months
Adherence to Online Support Groups
Adherence will be measured by comparing the number of participants offered the support group sessions with the number of participants who attend at least one 60-minute online session. This indicator reflects engagement and feasibility of the AGIS-TCA program's group component.
Time frame: At the end of the 3-month
Acceptability of Early Telephone Contact
Acceptability will be measured by the proportion of eligible patients successfully reached during the first telephone contact (AT1) compared with the total number of patients invited. It evaluates the practicality and acceptance of proactive outreach by patients awaiting care.
Time frame: first 7 days
Clinical and Sociodemographic Profile of Patients Requesting Specialized Care
Characterization of all patients requesting specialized care for eating disorders, based on collected data: age, sex, socioeconomic background, presumed diagnosis, and illness duration. This will provide a descriptive overview of the population accessing the service.
Time frame: the 6-month
Clinical and Sociodemographic Profile of Patients Lost to Follow-Up
Characterization of patients identified as lost to follow-up, using the same variables (age, sex, socioeconomic background, presumed diagnosis, illness duration) to identify potential predictors of disengagement from care.
Time frame: end of the 10-month
Plan to share: Undecided — The data will be used exclusively for the analyses planned in the protocol and will not be shared outside the study investigators.
No publications or documents are linked to this record.
Started Dec 2025 (actual). Primary completion is estimated for Apr 2027, 16 months after the start.
Of 269 non-industry interventional studies with no phase under Feeding and Eating Disorders, half reached primary completion within 28 months of starting (the median), counting those still running; a quarter within 14 and three quarters within 49. This study's planned 16 months is below that.
Counting every sponsor, half of 274 studies reached it within 28 months; a quarter within 14 and three quarters within 49.
How these figures are worked out, and which studies are left out of them.
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