An interventional study of Acceptance and Mindfulness Based Exposure Therapy and Present-Centered Therapy in PTSD - Post Traumatic Stress Disorder and Cardiac Arrest (CA), sponsored by Columbia University. Recruiting at 1 site in United States. Open to participants aged 18 Years to 81 Years. Per ClinicalTrials.gov, last updated 2026-04-09.
Sponsored by Columbia University · Not applicable, Interventional, and Treatment
The goal of this clinical trial is to learn if a new therapy called Acceptance- and Mindfulness-Based Exposure Therapy (AMBET) helps treat post-traumatic stress disorder (PTSD) in people who survived a cardiac arrest. This study will compare AMBET to another psychotherapy treatment called Present Centered Therapy (PCT) to see which therapy is more effective in treating PTSD.
The main questions it aims to answer are:
Does AMBET reduce PTSD symptoms in survivors of cardiac arrest? How do the benefits of AMBET compare to PCT?
Participants will:
200 studies on the registry are indexed under Combat Disorders; 90 are open to participants now.
This study's planned enrollment of 90 is above the median of 72 across 167 interventional studies indexed under Combat Disorders.
Browse Combat Disorders studies →Columbia University is the lead sponsor of 1,136 studies on the registry; 195 are open to participants now.
Of its 180 completed or terminated interventional studies of FDA-regulated products, 148 (82%) have results posted.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The American Psychiatric Association’s manual of mental health diagnoses. DSM-5 (2013, revised as DSM-5-TR in 2022) replaced DSM-IV, and some studies still name the older edition. “Meets DSM criteria for …” means diagnosed by that edition’s diagnostic criteria, usually by a clinician in an interview.
Short tests of memory and thinking, each scored out of 30. Lower scores suggest more difficulty; criteria give a range, either to include people with memory problems or to leave them out.
The study doctor’s estimate of how long someone is likely to live. Criteria use it so that people can stay in the study long enough for it to answer its question.
DSM diagnostic criteria
The American Psychiatric Association’s manual of mental health diagnoses. DSM-5 (2013, revised as DSM-5-TR in 2022) replaced DSM-IV, and some studies still name the older edition. “Meets DSM criteria for …” means diagnosed by that edition’s diagnostic criteria, usually by a clinician in an interview.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
MMSE and MoCA
Short tests of memory and thinking, each scored out of 30. Lower scores suggest more difficulty; criteria give a range, either to include people with memory problems or to leave them out.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Life expectancy
The study doctor’s estimate of how long someone is likely to live. Criteria use it so that people can stay in the study long enough for it to answer its question.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Remotely delivered psychotherapy combining exposure therapy with mindfulness.
Behavioral: Acceptance and Mindfulness Based Exposure Therapy
Remotely delivered psychotherapy that focuses on increasing adaptive responses to current life stressors and difficulties.
Behavioral: Present-Centered Therapy
Eight sessions of exposure therapy combined with mindfulness delivered via videoconferencing platform. AMBET will consist of 90-minute weekly sessions for 4 weeks, then every other week for 4 more sessions.
Also known as: AMBET
Twelve 60-minute weekly sessions of psychotherapy delivered via videoconferencing platform.
Also known as: PCT
Change in PTSD symptoms over time
Change in symptoms as measured by the Clinician Administered PTSD Scale (CAPS-5) from pre- to post-treatment. The full score range is 0 - 80, where lower scores indicate lower symptom levels of PTSD.
Time frame: Baseline, At 6 weeks, Post-treatment: Approximately 3 months and 6 months from intake
Change in depressive symptoms over time
Change in symptoms as measured by the Hamilton Depression Rating Scale (HDRS-24) from pre- to post-treatment. The full score range is 0 - 76, where lower scores indicate lower symptom levels of depression.
Time frame: Baseline, At 6 weeks, Post-treatment: approximately 3 months and 6 months from intake
Plan to share: Undecided
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