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CompletedNCT07385261CALAPUpdated Feb 4, 2026

Treatment Strategy for Complicated Pediatric Appendicitis Based on Laparoscopic Surgery

An interventional study of laparoscopic appendectomy in Appendix Diseases and Surgery, sponsored by Mohammad Daboos. Completed at 1 site in Egypt. Open to participants aged Up to 18 Years. Per ClinicalTrials.gov, last updated 2026-02-04.

Sponsored by Mohammad Daboos · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Registered 11 years after the study started (first participant enrolled Jan 2015, registered Jan 2026).
Phase
Not applicable
Study type
Interventional
Enrollment
765
Allocation
Not applicable
Ages
Up to 18 Years
Sex
All
01

Study summary

Observational retrospective study included 765 children with Operative management by laparoscopic appendectomy, conservative management for appendicular mass and drainage of abscess by IR should be tried first. Interval appendectomy is reserved only for patients with recurrent symptoms. the study collect the Diagnostic data ,intraoperative and post operative data to submit the strategies of laparoscopic management in limited resources setting.

Read the detailed description

Background and study aims: In children with complicated appendicitis significant morbidity exists with prolonged hospitalization and increased costs. The management strategy for complicated pediatric appendicitis differs depending on facility resources together with surgeon's experience. Various studies investigated the usefulness of laparoscopic than open surgery even in complicated appendicitis. However, the treatment strategy remains controversial, especially in appendicular mass as well as appendicular abscess.

Methods: This observational study included 765 children with complicated appendicitis. over 10 years period. Patients' demographics, clinical criteria for different presentations of complicated appendicitis, diagnostic work up, plans of treatment based on laparoscopic management were reviewed and analyzed regarding different variables and postoperative outcomes.

02

Conditions studied

  • Appendix Diseases
  • Surgery

Keywords

  • laparoscopic surgery
  • complicated appendicitis
03

In context

Lead sponsor

Mohammad Daboos is the lead sponsor of 5 studies on the registry; 2 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
Up to 18 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • laparoscopic management of Complicated Appendicitis with mass formation
  • laparoscopic management of Complicated appendicitis with abscess formation:
  • laparoscopic management of Complicated appendicitis with free intraperitoneal collection

Exclusion criteria

Exclusion Criteria:

  • Open surgery cases
  • Patients received incomplete antibiotic therapy
  • Accidental discovery coexistent pathology that necessitates open surgery
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Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
765 participants (actual)

Study arms

  • Experimental
    Complicated Appendicitis

    Complicated appendicitis: refer to acute appendicitis with perforation or gangrene, appendicular mass with or without abdominal abscess formation submitted for laparoscopic management with appendectomy and intraperitoneal suction of pus over the last 10 years

    Procedure: laparoscopic appendectomy

Interventions

  • Procedurelaparoscopic appendectomy

    Based on clinical findings, imaging studies and laboratory findings, after resuscitation, the decision of urgent surgery was according to the presentation Free peritoneal perforation (FPA) Perforated appendicitis with free peritoneal fluid were managed by urgent laparoscopic exploration Appendicular mass (AM) In patients presented by early mass formation lap exploration was carried out but trial of conservative management was planned for cases presented late with expected difficulty in lap dissection depending on surgical team and parental consultation, this accomplished by (nothing per mouth, I V fluid, I V antibiotic, temperature chart with U/S and biomarker follow up) Appendicular abscess (AAbs) Percutaneous drainage by availability IR team was the first choice however lap exploration and /or lap assisted extraperitoneal drainage was the second choice if IR failed or not available.

06

What researchers measure

Primary outcomes

  1. Primary outcomes

    postoperative outcomes any alarming symptoms of intestinal obstruction developed (vomiting, fever, or severe abdominal pain, intraperitoneal collections

    Time frame: 4 years

07

Study locations

1 site
  • Mohammad Daboos
    Cairo, 115678, Egypt
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Feb 4, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT07385261
Lead sponsor
Mohammad Daboos
Collaborators
South Valley University, Tanta University
Responsible party
Mohammad Daboos (Assistant professor of pediatric surgery, Faculty of Medicine, Al-Azhar University, Al-Azhar University) — Sponsor-investigator
First posted
Feb 4, 2026
Start date
Jan 1, 2015
Primary completion
Jan 1, 2025
Completion
Jan 1, 2026
Last update
Feb 4, 2026

Study contacts

‪Mohammad Daboos‬, Dr
principal investigator · Department of pediatric surgery, faculty of medicine , Al-Azhar University

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jan 2026. You cannot join it, but the record below documents what was studied.

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