An interventional study of Autologous Platelet-Rich Plasma (PRP) Dressing and Normal Saline Dressings in Wheel Spoke Injury, Heel Pad Injuries and Wound Healing, sponsored by Services Institute of Medical Sciences, Pakistan. Completed at 1 site in Pakistan. Open to participants aged 5 Years to 12 Years. Per ClinicalTrials.gov, last updated 2026-02-02.
Sponsored by Services Institute of Medical Sciences, Pakistan · Not applicable, Interventional, and Treatment
This study is testing whether autologous platelet rich plasma (PRP) dressings are more effective than normal saline dressings in treating heel pad injuries caused by motorcycle wheel spokes among children in Pakistan. PRP is prepared from a child's own blood and contains natural growth factors that may help wounds to heal faster. The study compares healing rates, reduction in wound size, and time to complete wound healing between the platelet-rich plasma and saline dressing groups.
Motorcycle wheel-spoke injuries occur when the heel or foot becomes entrapped in the spokes of a moving motorcycle, frequently resulting in severe soft tissue damage in children. Healing of these injuries is often prolonged and challenging. Platelet-rich plasma (PRP), prepared from a patient's own blood, contains a high concentration of growth factors that promote tissue regeneration, angiogenesis, and wound contraction. Previous studies in adults with diabetic and chronic ulcers have demonstrated that PRP may accelerate wound healing compared with conventional dressings.
However, evidence supporting the use of PRP in the pediatric population, particularly for heel pad injuries resulting from motorcycle wheel-spoke trauma, remains limited. This randomized controlled trial is designed to evaluate the efficacy of platelet-rich plasma dressing compared with saline dressing in children aged 5 to 12 years presenting with heel pad injuries.
A total of 60 participants will be enrolled and randomly assigned to receive either platelet-rich plasma dressing or saline dressing. Study outcomes will include wound healing within 12 weeks, duration of wound healing in days, and changes in wound size measured in both longitudinal and horizontal dimensions. This trial aims to generate evidence for a more effective and locally feasible wound management strategy for pediatric heel pad injuries in the study setting.
Services Institute of Medical Sciences, Pakistan is the lead sponsor of 33 studies on the registry; 6 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria :
Approximately 10 mL of venous blood is processed to prepare PRP, which is applied as a wound dressing for 3 days. Applied for about 4 weeks, with follow-up until 12 weeks.
Biological: Autologous Platelet-Rich Plasma (PRP) Dressing
Conventional sterile saline dressings are applied daily over \~4 weeks, with follow-up until 12 weeks.
Other: Normal Saline Dressings
Approximately 10 mL of venous blood is processed in the pathology department to prepare PRP, which is applied as a wound dressing. Dressings are applied over \~4 weeks, with outpatient follow-up until 12 weeks.
Conventional sterile normal saline dressings are applied over \~4 weeks, with outpatient follow-up until 12 weeks.
Wound Healing Status
Wound status based on presence of granulation tissue and measurement of wound size.
Time frame: Up to 12 weeks
Duration of healing
Number of days from baseline until there is no further change in wound size.
Time frame: Up to 12 weeks
Percentage Change in Longitudinal Wound Dimension
Calculated as (baseline longitudinal size - size at 12 weeks) ÷ baseline longitudinal size × 100.
Time frame: 12 weeks
Percentage Change in Horizontal Wound Dimension
Calculated as (baseline horizontal size-sizeat12weeks)÷base line horizontal size X 100
Time frame: 12 weeks
Plan to share: No — Individual participant data collected in this study will not be shared outside the study team to protect participant privacy and in accordance with local regulations.
This study is completed, as verified in Jan 2026. You cannot join it, but the record below documents what was studied.
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Services Institute of Medical Sciences, Pakistan