CClinicalTrials.gg
RecruitingNCT07376005Updated Jan 29, 2026

Effects of Acute Sugar Intake on Choroidal Thickness

An interventional study of Oral glucose in Choroid, sponsored by Southern College of Optometry. Recruiting at 1 site in United States. Open to participants aged 21 Years to 35 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-01-29.

Sponsored by Southern College of Optometry · Not applicable, Interventional, and Other

Phase
Not applicable
Study type
Interventional
Enrollment
47
Allocation
Not applicable
Ages
21 Years to 35 Years
Sex
All
01

Study summary

This study aims to bridge that gap by investigating how acute sugar intake influences choroidal thickness.

Read the detailed description

This investigation will be a prospective, repeated-measures study. All subjects will arrive fasted and will be asked not to consume any outside food or beverages during the three-hour study period, and will be asked to abstain from caffeine intake for 12 hours before participation. A baseline OCT scan of the macula of the right eye will be performed using the Heidelberg Spectralis OCT system. Participants will then consume 30 grams of sugar in the form of glucose tablets. Macular OCT scans of the right eye will be repeated every 30 minutes for 3 hours following sugar consumption.

02

Conditions studied

  • Choroid
03

Who can participate

Ages eligible
21 Years to 35 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • In order to be eligible for enrolment, each subject must have less than 6 diopters of spherical equivalent refractive error, and have no existing diagnosis of diabetes or pre-diabetes.

Exclusion criteria

Exclusion Criteria:

  • Any potential subject with known retinal pathology will be excluded. Any potential subject with any other known systemic or ocular conditions that may impact their ability to participate in the study or provide generalizable data will also be excluded.
04

Study design

Phase
Not applicable
Primary purpose
Other
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
47 participants (estimated)

Study arms

  • Active comparator
    Oral glucose

    Subjects receive 30g of oral glucose

    Dietary Supplement: Oral glucose

Interventions

  • Dietary supplementOral glucose

    Participants will consume 30 grams of sugar in the form of glucose tablets.

05

What researchers measure

Primary outcomes

  1. Change in choroidal thickness

    The primary outcome for this investigation will be changes in choroidal thickness from baseline across timepoints.

    Time frame: within 3 hours of baseline

06

Study locations

1 of 1 sites recruiting
  • Southern College of Optometry
    Memphis, Tennessee 38111, United States
    Recruiting
07

Registry details

Key details

Study ID
NCT07376005
Lead sponsor
Southern College of Optometry
Responsible party
Sponsor
First posted
Jan 29, 2026
Start date
Jan 2026 (estimated)
Primary completion
May 2026 (estimated)
Completion
May 2026 (estimated)
Last update
Jan 29, 2026

Study contacts

Morgan Ollinger, OD, MS
Contact
mollinger@sco.edu
9017223377

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Interested in this study?

Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.

Contact study team

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion